Effects of polystyrene nanoplastics on the bioaccumulation, distribution and parental transfer of ethylhexyl salicylate

Zhou, Ranran; Lu, Guanghua; Yan, Zhenhua; Jiang, Runren; Sun, Yu; Zhang, Peng

doi:10.1039/d1en01004b

Cited by 21 publications

(10 citation statements)

References 67 publications

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“…The presence of nine pharmaceuticals in the gonadal indicates that these pharmaceuticals could cross the blood–ovary barrier and increase the risk of transgenerational toxicity. Zhou et al [ 35 ] found that the distribution of ethylhexyl salicylate in gonads could be transferred to offspring through reproduction, thus influencing its growth, development, and locomotor vitality. In addition, the muscle also had a high concentration of pharmaceuticals.…”

Section: Resultsmentioning

confidence: 99%

Distribution, Bioaccumulation, and Risks of Pharmaceutical Metabolites and Their Parents: A Case Study in an Yunliang River, Nanjing City

Yan

Zhou

Zhang

et al. 2023

IJERPH

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The occurrence, bioaccumulation, and risks of 11 pairs of pharmaceutical metabolites and their respective parents were investigated in the water, sediment, and fish of an urban river in Nanjing city, China. The results showed that most of the target metabolites and their parents were detected in all water samples, with concentrations ranging from 0.1 ng/L to 72.9 ng/L. In some cases, the concentrations of metabolites in water were significantly higher than their parents, with fold changes reaching up 4.1 in the wet season and 6.6 in the dry season, while in sediment and fish, a lower concentration was observed in most cases. A lowered concentration of detected pharmaceuticals was observed in the dry season when compared to the wet season due to the seasonal variation in pharmaceutical consumption and overflow effluent. The bioaccumulation of pharmaceuticals in different fish tissues were detected with a descending order of overall concentration as gill > brain > muscle > gonad > intestine > liver > blood. In addition, the concentrations of both metabolites and their parents also decreased along the river in two seasons. However, the concentration rates of metabolites and their parents were significantly altered along the river in both water and sediment. The relatively high concentration proportions of the detected pharmaceuticals in water suggested that pharmaceuticals were more likely to apportion in water than in sediment, especially for the metabolites. Meanwhile, the rates of the metabolite/parent pairs between fish and water/sediment were generally lower, indicating the higher excretion capacity of metabolites from fish than their parents. Most of the detected pharmaceuticals had no impact on aquatic organisms. However, the presence of ibuprofen posed a medium risk to fish. Compared to the parents, metabolites showed a relatively low risk value but a high contribution to the total risk. It highlights that metabolites in the aquatic environments cannot be ignored.

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Section: Resultsmentioning

confidence: 99%

Distribution, Bioaccumulation, and Risks of Pharmaceutical Metabolites and Their Parents: A Case Study in an Yunliang River, Nanjing City

Yan

Zhou

Zhang

et al. 2023

IJERPH

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“…In addition, several studies have previously detected the presence of contaminants, such as persistent organic pollutants and nanoparticles, in the brains of zebrafish larvae exposed to exogenous contaminants, suggesting that all of the above substances can enter the CNS through the blood-brain barrier. Contaminants entering the brain can induce neurotoxicity at the cellular and molecular levels through oxidative stress or inflammatory responses (Lu et al, 2016;Zhou et al, 2022b), which could be the reason for the apoptosis induced by BM-BDM and 100 nm PS-NPs in this experiment.…”

Section: Apoptosis and Expression Of Apoptosisrelated Genes In The Cn...mentioning

confidence: 90%

“…Butyl methoxydibenzoyl methane (BM-DBM) is one of the main occurrences of OUVFs in the environment, whose levels in surface water (Rodriguez et al, 2015) and sediment (Tsui et al, 2015) can reach up to 1770.3 ng/L and 64.5 ng/g dry weight (dw), respectively, with an overall high level of contamination. In addition, OUVFs usually have high octanol-water partition coefficients (logKow = 4-8), which are prone to accumulate in the body and produce various toxic effects after ingestion by aquatic organisms (Zhou et al, 2022b). Ma et al (2017) found a significant decrease in acetylcholinesterase (AChE) and catalase activities and a significant increase in superoxide dismutase and glutathione reductase activities in crucian carp (Carassius auratus) after 28 days of exposure to BM-DBM, indicating an impairment of the nervous system and antioxidant defense system.…”

Section: Introductionmentioning

confidence: 99%

“…Microplastics (MPs), also a new pollutant, refer to organic polymeric plastic particles with particle sizes between 100 nm and 5 mm, of which polystyrene (PS) is the most commonly used one (Li et al, 2018;Jain et al, 2021;Zhou et al, 2022b). MPs below 100 nm, also known as nanoplastics (NPs), are usually derived from the fragmentation of large-size plastic waste.…”

Section: Introductionmentioning

confidence: 99%

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Interactive neurotoxicity of environmentally relevant concentrations of polystyrene nanoplastics and butyl methoxydibenzoyl methane on early zebrafish embryos

et al. 2022

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Organic ultraviolet filters (OUVFs) and nanoplastics (NPs) are two important new pollutants that coexist widely in freshwater and coastal habitats. Both OUVFs and MPs can be taken up by aquatic organisms and may be toxic or co-toxic. In this study, the neurotoxicity and interaction neurotoxicity of the typical OUVFs butyl methoxydibenzoyl methane (BM-DBM) and polystyrene nanoplastics (PS-NPs) on zebrafish at environmental concentrations were comprehensively investigated at the tissue and molecular levels using transgenic or non-transgenic zebrafish. Results showed that both BM-DBM and PS-NPs induced abnormal expression of developmental genes neurogenin 1, glial fibrillary acidic protein, Finkel-Biskis-Jinkins osteosarcoma oncogene, growth-associated protein 43, synapsin IIa, and apoptosis regulator a (Bcl2a), Bcl2 associated x and apoptosis-related cysteine peptidase a, neuronal loss, motor neuron axon deletion, neuronal apoptosis and behavioral abnormalities in larvae thus being neurotoxic. BM-DBM also specifically interferes with neurotransmitter systems and affects signaling between neurons. In addition, PS-NPs and BM-BDM exerted synergistic and antagonistic effects in inducing apoptosis in neuronal cells and developmental neurotoxicity, respectively. Our results highlight the neurotoxic risk of PS-NPs and BM-BDM and the complex interactive neurotoxic effects of the two. We anticipate that our study may lay the foundation for ecological risk assessment of OUVFs and PS-NPs and exploration of complex interactions between PS-NPs and hydrophobic organic pollutants.

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“…Moreover, the cell permeability of gills, in direct contact with the surrounding medium, can act as a protective barrier against xenobiotics. This could reduce pollutant accumulation through the direct route 32 . We observed through the waterborne exposure a strong production of mucus coming out from the clams' valves which could also act as a protective mechanism of gills towards contamination by trapping NPs and rejecting them into the surrounding medium.…”

Section: Differences Between Gills and Visceral Massmentioning

confidence: 99%

Origin, exposure routes and xenobiotics impart nanoplastics with toxicity on freshwater bivalves

Arini

Muller

Coma

et al. 2022

Preprint

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Various environmental aged plastic wastes were collected in the environment and crushed to the nanometric scale to get a mix of nanoplastics (NPs) of different natures - mostly polyolefins (PE, PP), polyesters (PET) and polyvinylics (PS and PVC) - and undefined shapes (noted NP-L, mean hydrodynamic diameter at 285 nm). We aimed to test the toxicity of NPs of environmentally relevance on freshwater bivalves and compare results to commonly used styrenic NP-PS (206 nm). Corbicula fluminea were exposed to four different conditions with NPs (0.008 to 10 ug/L), for 21 days and kept under depuration conditions for 21 additional days: 1) waterborne exposure to NP-L, 2) diet borne exposure to NP-L, 3) synergic waterborne exposure to NP-L and AlCl3 salt (1 mg/L), 4) waterborne exposure to NP-PS. Enzyme activities, gene expressions and behavioural tests were assessed. Trophic and synergic exposures with Al triggered more gene modulations than direct exposure to NP-L (namely on 12s, atg12, gal, segpx, p53 and ache). NP-PS were also more harmful than NP-L, but only at high concentrations (10 ug/L). The effects of each treatment lasted until 7 days of depuration and no more gene inductions were observed after 21 days in clean water. Very few effects were shown on phenol-oxidase (PO), and glutathione S-transferase (GST). However, the inhibition of acetylcholinesterase (AchE) was concomitant with an increase of the filtration activity of bivalves exposed to NP-L (trophic route) and NP-PS, suggesting neurotoxic effects. By disturbing the ventilatory activity, NPs could have direct effects on xenobiotic accumulation and excretion capacities. The results point out how the structure, aging, exposure routes and additional xenobiotics can interact with adverse outcomes of NPs in bivalves. These findings underline the importance to consider naturally aged environmental NPs in ecotoxicological studies rather than synthetic latexes, i.e. crosslinked nanospheres prepared from virgin polymers.

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Effects of polystyrene nanoplastics on the bioaccumulation, distribution and parental transfer of ethylhexyl salicylate

Abstract: In this study, the accumulation and distribution of ethylhexyl salicylate (EHS) and polystyrene nanoplastics (PS-NPs) in parental zebrafish (Danio Rerio) and offspring, and the effects of PS-NPs on EHS bioavailability...

Cited by 21 publications

References 67 publications

Distribution, Bioaccumulation, and Risks of Pharmaceutical Metabolites and Their Parents: A Case Study in an Yunliang River, Nanjing City

Distribution, Bioaccumulation, and Risks of Pharmaceutical Metabolites and Their Parents: A Case Study in an Yunliang River, Nanjing City

Interactive neurotoxicity of environmentally relevant concentrations of polystyrene nanoplastics and butyl methoxydibenzoyl methane on early zebrafish embryos

Origin, exposure routes and xenobiotics impart nanoplastics with toxicity on freshwater bivalves

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