Bioaccumulation and analytics of pharmaceutical residues in the environment: A review

Puckowski, Alan; Mioduszewska, Katarzyna; Łukaszewicz, Paulina; Borecka, Marta; Caban, Magda; Maszkowska, Joanna; Stepnowski, Piotr

doi:10.1016/j.jpba.2016.02.049

Cited by 251 publications

(119 citation statements)

References 270 publications

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“…Such observations have, for instance been made for propranolol which is a widely used beta-blocker (Ding et al 2015) and the macrolide antibiotic roxithromycin (Liu et al 2014). The body of knowledge on accumulation of pharmaceuticals in aquatic biota has extensively increased over the years, yet there remains a need to fully elucidate all transfer routes, estimate environmental and human risks, and screen the content of APIs in waterborne foodstuffs (Puckowski et al 2016). …”

Section: Fate Of Pharmaceuticals In the Freshwater Environmentmentioning

confidence: 99%

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

Rzymski

Drewek

Klimaszyk

2017

Limnological Review

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Abstract:The global use of pharmaceuticals is on the systematic rise and leads to contamination of surface waters with xenobiotic compounds with a wide range of bioactivity. Waters that receive urban and medical effluents are particularly threatened. The presence of pharmaceuticals in these ecosystems can lead to unpredictable ecological impacts and responses, and may also have an impact on human health. At the same time the identification and quantification of these chemicals, to a large extent remains a subject to scientific investigation than part of a thorough monitoring programme. Their biological effects on aquatic organisms are mainly recognized experimentally and often using concentrations far exceeding environmentally relevant levels. This review paper defines the main sources of pharmaceuticals in the aquatic environment, discusses the fate of these compounds and summarizes the current state-of-the-art of pharmaceutical monitoring in Polish surface waters.

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Section: Fate Of Pharmaceuticals In the Freshwater Environmentmentioning

confidence: 99%

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

Rzymski

Drewek

Klimaszyk

2017

Limnological Review

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“…They are mostly introduced in the sewage system through excretion of unmetabolized compounds after medical use or inappropriate disposal and insufficient removal by conventional wastewater treatment plants (WWTPs), which are not designed to treat water polluted with pharmaceuticals present at trace levels . Even though, they are detected at low or very low concentrations (ng L ‐1 to μg L ‐1 ), their continuous input to the environment may lead to prolonged exposure and thus may have adverse effects on non‐target organisms, acting as slightly persistent pollutants …”

Section: Introductionmentioning

confidence: 99%

“…8 Even though, they are detected at low or very low concentrations (ng L -1 to g L -1 ), their continuous input to the environment may lead to prolonged exposure and thus may have adverse effects on non-target organisms, acting as slightly persistent pollutants. 9,10 Psychoactive compounds are a wide group of drugs used to treat symptoms of neurological disorders. According to Global Burden of Disease Study, jointly published by World Health Organization (WHO) and other groups, neuropsychiatric disorders have emerged as priority health problems worldwide, projected to be the second most frequent disease by 2020.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous and homogeneous photocatalytic degradation of psychoactive drug Fluvoxamine: kinetic study, inorganic ions and phytotoxicity evaluation

Tsoumachidou

Κούρας

Poulios

2018

J of Chemical Tech & Biotech

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BACKGROUND Pharmaceutically active compounds, emerging extensively in ecosystems as pollutants, have become an important environmental and public health issue, since they can contaminate drinking water and pose threats to wildlife and human health. As a result, efforts should be made to develop methods to inactivate or eliminate this class of substance in the environment. RESULTS The photocatalytic degradation of psychoactive drug Fluvoxamine has been investigated. In the case of heterogeneous photocatalytic oxidation, the effect of TiO2 P25 concentration (0.1–1 g L‐1), initial concentration of H2O2 (0.25–0.2 g L‐1) and Fe3+ (0.00175–0.014 g L‐1) and pH of the solution on initial reaction rates were evaluated, while for homogeneous photocatalytic oxidation the effect of the amount of H2O2 (0.25–0.2 g L‐1) and Fe3+ (0.00175–0.014 g L‐1) were investigated. In addition, the conversion of the heteroatoms in the FVX molecule to inorganic ions (NO3‐, NH4+, F‐) during the photocatalytic process has been observed and phytotoxicity testing, using three plant species, was carried out in order to examine the effect of photocatalytic oxidation on the toxicity of FVX. CONCLUSION According to the results presented in this study, both heterogeneous and homogeneous photocatalytic oxidation is an efficient methodology for FVX degradation. © 2017 Society of Chemical Industry

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“…These compounds are released into the aquatic environment through human waste (Kosjek, Heath, & Krbavčič, ) and are detected in aquatic environment compartments at low or very low concentrations (ng L −1 to μg L −1 ). The continuous input into the environment may lead to prolonged exposure and thus may cause adverse effects on nontarget organisms (Puckowski et al, ). For example, NSAIDs in industrial effluent could induce geno‐ and cytotoxicity in common carp ( Cyprinus carpio ; SanJuan‐Reyes et al, ), and ibuprofen and diclofenac have significant bioaccumulation and cellular effects in Mytilus galloprovincialis (Mezzelani et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…The continuous input into the environment may lead to prolonged exposure and thus may cause adverse effects on nontarget organisms (Puckowski et al, 2016). For example, NSAIDs in industrial effluent could induce geno-and cytotoxicity in common carp (Cyprinus carpio; SanJuan-Reyes et al, 2015), and ibuprofen and diclofenac have significant bioaccumulation and cellular effects in Mytilus galloprovincialis (Mezzelani et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Preparation of dummy template‐imprinted polymers for the rapid extraction of nonsteroidal anti‐inflammatory drugs residues in aquatic environmental samples

Zhang

Chen

Zhao

2018

Biomedical Chromatography

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A molecularly imprinted polymer was synthesized and applied as a sorbent in the solid-phase extraction device. The imprinted polymer was characterized by fourier-transform infrared spectroscopy and scanning electron microscope. The results revealed that imprinted polymer possess sensitive selectivity and reliable adsorption properties for five NSAIDs. The imprinted polymer was successfully applied to the pre-concentration for five NSAIDs in different water samples prior to UPLC-MS/MS. In the early studies, several factors were investigated, including pH adjustment, the kind of elution solvent and the volume of elution solvent. Finally, we found that the pH 5 and an aliquot of 2 mL methanol were suitable for the water samples. The limits of detection and limits of quantitation of five nonsteroidal anti-inflammatory drugs varied from 0.007 to 0.480 μg L and 0.03 to 1.58 μg L , respectively. The spiking recoveries of the target analytes were 50.33-127.64% at the levels of 0.2 μg L , 2 μg L and 5 μg L . The precision and accuracy of this method showed a great increase compared with traditional solid-phase extraction. The developed method was successfully applied to extraction and analysis of NSAIDs in different water samples with satisfactory results which could help us better understand their environmental fate and risk to ecological health.

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Bioaccumulation and analytics of pharmaceutical residues in the environment: A review

Cited by 251 publications

References 270 publications

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

Pharmaceutical pollution of aquatic environment: an emerging and enormous challenge

Heterogeneous and homogeneous photocatalytic degradation of psychoactive drug Fluvoxamine: kinetic study, inorganic ions and phytotoxicity evaluation

Preparation of dummy template‐imprinted polymers for the rapid extraction of nonsteroidal anti‐inflammatory drugs residues in aquatic environmental samples

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