Bioaccumulating substances and reproductive success in baltic flounder platichthys flesus

Westernhagen, Hein von; Rosenthal, H.; Dethlefsen, Volkert; Ernst, W.; Harms, Uwe; Hansen, Peter-Diedrich

doi:10.1016/0166-445x(81)90032-1

Cited by 137 publications

(49 citation statements)

References 32 publications

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“…There is a wealth of information on the experimentally determined influence of pollutants such as chlorinated hydrocarbons on the development and the reproductive capacity of fish (Allison et al 1964, Hogan & Brauhn 1975, and some investigations exist on the impairment of reproduction caused by contaminants occurring In the field (Westernhagen et al 1981, Hansen et al 1985, Spies & Rice 1988. The development of the embryo may be disturbed by contaminants entering the egg during the time of maturation in the female gonads, or pollutants may interfere with development after the release of the spawning product into the surrounding water before and after fertilization.…”

Section: Discussionmentioning

confidence: 99%

“…Experiments show that concentrations of several chlorinated hydrocarbons, e.g. PCB, DDE and Dieldnn, found in natural flatfish populations lead to malformations during embryonic development which reduce hatching success (Westernhagen et al 1981, Hansen et al 1985, Spies et al 1988. This is only one group of many potential toxicants that may produce the biological effects which are the focus of this investigation.…”

Section: Introductionmentioning

confidence: 99%

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Morphological and chromosomal aberrations during embryonic development in dab Limanda limanda

Cameron¹,

Berg²

1992

Mar. Ecol. Prog. Ser.

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During the Bremerhaven Workshop, ichthyoplankton samples were collected with horizontal subsurface hauls at 28 stations from the inner German Bight to the Dogger Bank. Directly after being caught fish embryos were examined a l~v e for morphological developmental defects under a dissecting microscope. Investigations on chromosomal aberrations were confined to preserved blastula stages of dab and were carried out later in the laboratory. Main species sampled were dab Limanda limanda, plaice Pleuronectes platessa, sprat Sprattus sprattus and whiting Merlangius merlangus. Because of their widespread distribution and high numerical occurrence, dab embryos were best suited for the detection of regional differences in malformation frequencies. The proportion of malformations in the most sensitive early developmental stage of dab reached 32 % in the inner part of the German Bight and fell to 9 % further offshore, increasing again at the Dogger Bank to values up to 31 %. Data collection was acconlplished with a computerized data sampling/evaluation/presentation system, and results concerning the morphological differences of malformation frequencies were available directly after observation. Thus, the method as described below proved to be a suitable approach for b~ological effects mon~toring. Anaphase aberration frequencies in dab en~bryos reached a peak of 63 % in the inner part of the German Bight, whereas the lowest value (51 %) was detected far offshore at a less polluted station; aberrations on the Dogger Bank were found to be 57 %. Investigations on the chromosomal aberrations in the same material used for the determination of morphological aberrations provided an opportunity to evaluate the potential effects of contaminants at the chromosome level.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morphological and chromosomal aberrations during embryonic development in dab Limanda limanda

Cameron¹,

Berg²

1992

Mar. Ecol. Prog. Ser.

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“…Elevated levels of contaminants, including chlorinated hydrocarbons, in several other fish species are associated with reproductive impairment (Cameron et al 1992;Drevnick and Sandheinrich 2003;Hammerschmidt et al 2002;Longwell et al 1992), reduced egg viability (Billsson et al 1998;Giesy et al 1986;Mac and Edsall 1991;Matta et al 1997;Von Westernhagen et al 1981), reduced survival of larval fish (Berlin et al 1981;Giesy et al 1986), delayed maturity (Jorgensen et al 2004) and posterior malformations (Billsson et al 1998). Pesticide exposure in fish may affect antipredator and homing behavior, reproductive function, physiological development, and swimming speed and distance (Beauvais et al 2000;Moore and Waring 2001;Scholz et al 2000;Waring and Moore 2004).…”

Section: Marine Pollution and Environmental Contaminationmentioning

confidence: 99%

Kemp's Ridley Sea Turtle Saga and Setback: Novel Analyses of Cumulative Hatchlings Released and Time-Lagged Annual Nests in Tamaulipas, Mexico

Caillouet¹,

Gallaway

Putman

2016

Chelonian Conservation and Biology

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“…Exposure to organic chemicals has been correlated with severe mortality in several bird species (Koeman et al 1973) and with a reduction of reproductive performance in mammals (Reijnders 1986), birds (O'Shea et al 1980) and several fish species (Von Westernhagen et al 1981, 1987, Spies et al 1988. Female or male juvenile alligators from a contaminated lake in Florida exhibited abnormal gonad development and abnormal sex hormone concentrations compared with alligators from a control lake (Guillette et al 1994).…”

Section: Introductionmentioning

confidence: 99%

Two complementary bioassays for screening the estrogenic potency of xenobiotics: recombinant yeast for trout estrogen receptor and trout hepatocyte cultures

Petit¹,

Goff²,

Cravedi³

et al. 1997

Journal of Molecular Endocrinology

173

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A relation between the chemical structure of a xenobiotic and its steroidal action has not yet been clearly established. Thus, it is not possible to define the estrogenic potency of different xenobiotics. An assessment may be accomplished by the use of different bioassays. We have previously developed a yeast system highly and stably expressing rainbow trout estrogen receptor (rtER) in order to analyze the biological activity of the receptor. The recombinant yeast system appears to be a reliable, rapid and sensitive bioassay for the screening and determination of the direct interaction between ER and estrogenic compounds. This system was used in parallel with a more elaborate biological system, trout hepatocyte aggregate cultures, to examine the estrogenic potency of a wide spectrum of chemicals commonly found in the environment. In hepatocyte cultures, the vitellogenin gene whose expression is principally dependent upon estradiol was used as a biomarker. Moreover, competitive binding assays were performed to determine direct interaction between rtER and xenobiotics. In our study, 50%of the 49 chemical compounds tested exhibited estrogenic activity in the two bioassays: the herbicide diclofop-methyl; the fungicides biphenyl, dodemorph, and triadimefon; the insecticides lindane, methyl parathion, chlordecone, dieldrin, and endosulfan; polychlorinated biphenyl mixtures; the plasticizers or detergents alkylphenols and phthalates; and phytoestrogens. To investigate further biphenyl estrogenic activity, its principal metabolites were also tested in both bioassays. Among these estrogenic compounds, 70% were able to activate rtER in yeast and hepatocytes with variable induction levels according to the system. Nevertheless, 30% of these estrogenic compounds exhibited estrogenic activity in only one of the bioassays, suggesting the implication of metabolites or different pathways in the activation of gene transcription. This paper shows that it is important to combine in vivo bioassays with in vitro approaches to elucidate the mechanism of xenoestrogen actions.

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Bioaccumulating substances and reproductive success in baltic flounder platichthys flesus

Cited by 137 publications

References 32 publications

Morphological and chromosomal aberrations during embryonic development in dab Limanda limanda

Morphological and chromosomal aberrations during embryonic development in dab Limanda limanda

Kemp's Ridley Sea Turtle Saga and Setback: Novel Analyses of Cumulative Hatchlings Released and Time-Lagged Annual Nests in Tamaulipas, Mexico

Two complementary bioassays for screening the estrogenic potency of xenobiotics: recombinant yeast for trout estrogen receptor and trout hepatocyte cultures

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