Bioaccessibility of bioactive peptides: recent advances and perspectives

Udenigwe, Chibuike C.; Abioye, Raliat O.; Okagu, Innocent Uzochukwu; Obeme-Nmom, Joy I.

doi:10.1016/j.cofs.2021.03.005

Cited by 67 publications

(36 citation statements)

References 56 publications

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“…There is a need to test the clinical effectiveness of these isolated compounds in trypanosoma infection to clarify if their in vitro activities can translate into clinically relevant in vivo effects. This is because some therapeutic agents that are active in culture studies are not biostable in the gastrointestinal tract or may face transport barriers during transepithelial transport when orally ingested (Udenigwe et al, 2021). Apart from trypanosomiasis, malaria is another parasitic disease targeted with some Z. species.…”

Section: Zanthoxylum Species As Potential Source Of Anti-parasitic Agentsmentioning

confidence: 99%

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

et al. 2021

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The health benefits and toxicity of plant products are largely dependent on their secondary metabolite contents. These compounds are biosynthesized by plants as protection mechanisms against environmental factors and infectious agents. This review discusses the traditional uses, phytochemical constituents and health benefits of plant species in genus Zanthoxylum with a focus on cancer, microbial and parasitic infections, and sickle cell disease as reported in articles published from 1970 to 2021 in peer-reviewed journals and indexed in major scientific databases. Generally, Z. species are widely distributed in Asia, America and Africa, where they are used as food and for disease treatment. Several compounds belonging to alkaloids, flavonoids, terpenoids, and lignans, among others have been isolated from Z. species. This review discusses the biological activities reported for the plant species and their phytochemicals, including anticancer, antibacterial, antifungal, antiviral, anti-trypanosomal, antimalarial and anti-sickling properties. The safety profiles and suggestions for conservation of the Z. species were also discussed. Taken together, this review demonstrates that Z. species are rich in a wide range of bioactive phytochemicals with multiple health benefits, but more research is needed towards their practical application in the development of functional foods, nutraceuticals and lead compounds for new drugs.

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Section: Zanthoxylum Species As Potential Source Of Anti-parasitic Agentsmentioning

confidence: 99%

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

et al. 2021

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“…Though these peptides have shown promising in vitro results, sometimes they are ineffective under in vivo conditions. This may be due to the activity of gastrointestinal enzymes, which degrade these peptides to limit absorption and bioavailability [11,96]. As protein hydrolysates contain a mixture of different peptides, the identification of specific peptides remains a challenge.…”

Section: Antihypertensive Activitymentioning

confidence: 99%

Production, Purification, and Potential Health Applications of Edible Seeds’ Bioactive Peptides: A Concise Review

Samtiya

Acharya²,

Pandey³

et al. 2021

Foods

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Edible seeds play a significant role in contributing essential nutritional needs and impart several health benefits to improve the quality of human life. Previous literature evidence has confirmed that edible seed proteins, their enzymatic hydrolysates, and bioactive peptides (BAPs) have proven and potential attributes to ameliorate numerous chronic disorders through the modulation of activities of several molecular markers. Edible seed-derived proteins and peptides have gained much interest from researchers worldwide as ingredients to formulate therapeutic functional foods and nutraceuticals. In this review, four main methods are discussed (enzymatic hydrolysis, gastrointestinal digestion, fermentation, and genetic engineering) that are used for the production of BAPs, including their purification and characterization. This article’s main aim is to provide current knowledge regarding several health-promoting properties of edible seed BAPs in terms of antihypertensive, anti-cancer, antioxidative, anti-inflammatory, and hypoglycemic activities.

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“…In a similar experiment, the rate of absorption of LTFPGSAED and its metabolite, LTFPG, in culture Caco-2 cells were improved when mixed with YDFYPSSTKDQQS and LILPKHSDAD [ 32 ]. Considering the opinion of Sun et al [ 157 ] and Udenigwe et al [ 158 ] that other components of the matrix via which some peptides are delivered influence their biostability, bioaccessibility and bioavailability, all of which impact negatively on their bioactivities, the effect of food matrix on the bioactivities of LDPs should be investigated. This is to select the best matrix for delivering LDPs to achieve the desired health benefits.…”

Section: Transepithelial Transport Biostability and Bioavailability Of Ldpsmentioning

confidence: 99%

Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits

et al. 2021

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There is a renewed interest on the reliance of food-based bioactive compounds as sources of nutritive factors and health-beneficial chemical compounds. Among these food components, several proteins from foods have been shown to promote health and wellness as seen in proteins such as α/γ-conglutins from the seeds of Lupinus species (Lupin), a genus of leguminous plant that are widely used in traditional medicine for treating chronic diseases. Lupin-derived peptides (LDPs) are increasingly being explored and they have been shown to possess multifunctional health improving properties. This paper discusses the intestinal transport, bioavailability and biological activities of LDPs, focusing on molecular mechanisms of action as reported in in vitro, cell culture, animal and human studies. The potentials of several LDPs to demonstrate multitarget mechanism of regulation of glucose and lipid metabolism, chemo- and osteoprotective properties, and antioxidant and anti-inflammatory activities position LDPs as good candidates for nutraceutical development for the prevention and management of medical conditions whose etiology are multifactorial.

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Bioaccessibility of bioactive peptides: recent advances and perspectives

Cited by 67 publications

References 56 publications

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

Production, Purification, and Potential Health Applications of Edible Seeds’ Bioactive Peptides: A Concise Review

Lupin-Derived Bioactive Peptides: Intestinal Transport, Bioavailability and Health Benefits

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