Bioabsorbable metal screws in traumatology: A promising innovation

Biber, Roland; Pauser, Josef; Brem, Matthias; Bail, Hermann Josef

doi:10.1016/j.tcr.2017.01.012

Cited by 78 publications

(57 citation statements)

References 13 publications

(25 reference statements)

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“…Mg-based stents also showed a continuous desirable safety profile when clinically tested in humans [7]. These are only few recent examples of absorbable metal implant development besides the recent commercial launch of Mg bone screws and pins by a German company [8].…”

Section: Introductionmentioning

confidence: 99%

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

et al. 2019

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Absorbable metals have been introduced as materials to fabricate temporary medical implants. Iron, magnesium and zinc have been considered as major base elements of such metals. The metallurgical characterization and in-vitro corrosion assessment of these metals have been covered by the new ASTM standards F3160 and F3268. However, the in-vivo corrosion characterization and assessment of absorbable metal implants are not yet well established. The corrosion of metals in the in-vivo environment leads to metal ion release and corrosion product formation that may cause excessive toxicity. The aim of this work is to introduce the techniques to assess absorbable metal implants and their in-vivo corrosion behavior. This contains the existing approaches, e.g., implant retrieval and histological analysis, ultrasonography and radiography, and the new techniques for real-time in-vivo corrosion monitoring.

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Section: Introductionmentioning

confidence: 99%

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

et al. 2019

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“…While additively manufactured Mg implants have not yet been commercialised, the example of the compression screw MAGNEZIX® CS (Syntellix AG, Germany) as the first WE43 implant for application in humans (Fig. 1) is notable [35,51]. There have been few investigations on the use of such Mg-based implants in chevron osteotomies for hallux valgus corrective surgery [52], reporting significant functional outcomes, which were maintained for a period of at least 3 to 6 months postoperative.…”

Section: Discussionmentioning

confidence: 99%

“…Timeline displaying a historical background of AM-Mg research and development, indicating "landmarks" since the first scientific study on utilisation of AM to sinter Mg powder, from [18][19][20][21][22][23][24][25][26][27][28][29][33][34][35][36][37][38]. The images shown in the left-hand side were reproduced with permission from Elsevier.…”

Section: Introductionmentioning

confidence: 99%

A detailed microstructural and corrosion analysis of an additively manufactured magnesium alloy produced by selective laser melting

Esmaily¹,

Zeng²,

Mortazavi³

et al. 2020

Preprint

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Magnesium (Mg) alloys have promising potentials for lightweight and biomedical applications. Although there has been a recent interest in producing Mg alloys (including AZ, ZK and WE series) using additive manufacturing (AM), the process-structure-corrosion properties relationships in AM Mg alloys are yet to be understood. Herein, the production of Mg alloy WE43 was achieved by selective laser melting (SLM). The alloy was investigated after SLM, hot isostatic pressing (HIP) as well as an additional solutionising heat treatment. Specimens were carefully characterised, whilst assessed and contrast relative to the conventionally cast alloy counterpart. Characterisation included detailed microstructural analysis employing analytical transmission electron microscopy, X-ray mapping, and electron backscatter diffraction, which revealed the SLM prepared specimens possess a unique microstructure comprising fine grains growing with a strong [0001] texture along the building direction. The SLM prepared specimens also revealed a low fraction of process-induced and metallurgical defects, reaching < 0.1% after optimising the SLM parameters and HIP treatment. The SLM prepared WE43 was found to be cathodically more active relative to the cast WE43 because of a fine distribution of zirconium-, yttrium- and oxygen-rich particles as well as the alterations in the chemical composition of the solid-solution matrix originating from the high cooling rates of SLM. It was revealed that the oxide particles were mainly sourced by powder and thus it is hypothesised that the corrosion of SLM prepared Mg alloys could be greatly improved once the influence of powder characteristics is further understood and controlled.

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“…Furthermore, recently an additional interference screw, made of an MgYREZr-alloy, has been introduced to the market (Milagro; DePuy Mitek, Leeds, United Kingdom) [95]. A transient appearance of radio translucent areas around magnesium implants was reported [96]. In fact, such a phenomenon would be expected from the above proposed mechanism; an initial magnesium implant size expansion by the deposition and the subsequent resorption of solid corrosion products, leaving a temporary void space to be filled by bony tissue.…”

Section: Characteristics Of Magnesium-based Implantsmentioning

confidence: 99%

Advances and Challenges of Biodegradable Implant Materials with a Focus on Magnesium-Alloys and Bacterial Infections

Rahim

Ullah

Mueller

2018

Metals

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Medical implants made of biodegradable materials could be advantageous for temporary applications, such as mechanical support during bone-healing or as vascular stents to keep blood vessels open. After completion of the healing process, the implant would disappear, avoiding long-term side effects or the need for surgical removal. Various corrodible metal alloys based on magnesium, iron or zinc have been proposed as sturdier and potentially less inflammatory alternatives to degradable organic polymers, in particular for load-bearing applications. Despite the recent introduction of magnesium-based screws, the remaining hurdles to routine clinical applications are still challenging. These include limitations such as mechanical material characteristics or unsuitable corrosion characteristics. In this article, the salient features and clinical prospects of currently-investigated biodegradable implant materials are summarized, with a main focus on magnesium alloys. A mechanism of action for the stimulation of bone growth due to the exertion of mechanical force by magnesium corrosion products is discussed. To explain divergent in vitro and in vivo effects of magnesium, a novel model for bacterial biofilm infections is proposed which predicts crucial consequences for antibacterial implant strategies.

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Bioabsorbable metal screws in traumatology: A promising innovation

Cited by 78 publications

References 13 publications

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

A detailed microstructural and corrosion analysis of an additively manufactured magnesium alloy produced by selective laser melting

Advances and Challenges of Biodegradable Implant Materials with a Focus on Magnesium-Alloys and Bacterial Infections

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