Bioabsorbable Implants

Spitalny, A. Douglas

doi:10.1016/j.cpm.2006.06.001

Cited by 11 publications

(5 citation statements)

References 41 publications

(45 reference statements)

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“…Absorbable materials made of PGA or PLA are broken down via hydrolysis in the body (24). With the accumulation of the breakdown products, foreign body reactions, including sterile effusion, sinus formation and osteolysis around the implants, are triggered (25).…”

Section: Discussionmentioning

confidence: 99%

Absorbable implants versus metal implants for the treatment of ankle fractures: A meta-analysis

Guo

et al. 2013

Experimental and Therapeutic Medicine

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This meta-analysis was performed to evaluate the efficiency and the safety of absorbable implants. Five major electronic databases (PubMed, Embase, Cochrane Library, SinoMed and Wanfang Data) were systematically searched for randomized controlled trials (RCTs) from their establishment to November 2012. Studies on absorbable implants and metal implants for ankle fractures were selected. The meta-analysis was performed using RevMan 5.1. Ten studies with 762 patients were included and analyzed. Compared with metal implants, absorbable implants used for the internal fixation of ankle fractures produce similar radiographic and functional outcomes (P= 0.52). Normally, removal of the internal fixation is unnecessary (P<0.0001) and the incidence of palpable implants is lower (P=0.02) for absorbable implants. No statistically significant difference was observed between the two groups with regard to foreign body reactions (P=0.07), infection (P= 0.69), osteoarthritis (P= 0.39), pain (P= 0.06), refracture (P=0.67), skin necrosis (P=0.99), deep vein thrombosis (P=0.21) and nerve injury (P=0.94). Absorbable implants used in ankle fractures rarely require reoperation and result in similar functional outcomes and complications compared with metal implants. These characteristics make them efficient and reasonably safe for the treatment of ankle fractures.

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Section: Discussionmentioning

confidence: 99%

Absorbable implants versus metal implants for the treatment of ankle fractures: A meta-analysis

Guo

et al. 2013

Experimental and Therapeutic Medicine

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“…Biodegradable materials are frequently employed in medical sutures, drug release carriers, tissue engineering, and other sectors, such as orthopaedics, maxillofacial surgery, cardiovascular surgery, and plastic surgery ( Spitalny, 2006 ). Yin et al (2022) used 3D printing technology to investigate the phased degradation of poly-l-actide (PLLA) vascular scaffolds in mice, as well as the alteration of vascular endothelial cells during scaffold degradation, to elucidate the long-term effects of poly-l-actide vascular scaffolds (PLSs) on vascular repair and to demonstrate the potential of PLSs in promoting endothelial function and positive remodelling.…”

Section: Biodegradable Ivcfmentioning

confidence: 99%

The application of inferior vena cava filters in orthopaedics and current research advances

Wang

Zhou

et al. 2022

Front. Bioeng. Biotechnol.

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Deep vein thrombosis is a common clinical peripheral vascular disease that occurs frequently in orthopaedic patients and may lead to pulmonary embolism (PE) if the thrombus is dislodged. pulmonary embolism can be prevented by placing an inferior vena cava filter (IVCF) to intercept the dislodged thrombus. Thus, IVCFs play an important role in orthopaedics. However, the occurrence of complications after inferior vena cava filter placement, particularly recurrent thromboembolism, makes it necessary to carefully assess the risk-benefit of filter placement. There is no accepted statement as to whether IVCF should be placed in orthopaedic patients. Based on the problems currently displayed in the use of IVCFs, an ideal IVCF is proposed that does not affect the vessel wall and haemodynamics and intercepts thrombi well. The biodegradable filters that currently exist come close to the description of an ideal filter that can reduce the occurrence of various complications. Currently available biodegradable IVCFs consist of various organic polymeric materials. Biodegradable metals have shown good performance in making biodegradable IVCFs. However, among the available experimental studies on degradable filters, there are no experimental studies on filters made of degradable metals. This article reviews the use of IVCFs in orthopaedics, the current status of filters and the progress of research into biodegradable vena cava filters and suggests possible future developments based on the published literature by an electronic search of PubMed and Medline databases for articles related to IVCFs searchable by October 2022 and a manual search for citations to relevant studies.

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“…Scheduled or unplanned removal of these implants bear surgical risks and costs brought on by second operations. Therefore, material science aims to develop and improve biodegradable implants where hardware removal is unnecessary due to their integration while providing higher strength than equivalents currently available on the market (i.e., polymers) [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Magnesium‐Based Compression Screws in Acute Scaphoid Fractures and Nonunions

2023

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Background Magnesium-based bioabsorbable osteosynthesis material continues to receive increasing attention. The following study documents our experience with bioabsorbable magnesium screws in scaphoid fracture treatment in hopes to capture further evidence and successful application. Methods Eight acute scaphoid fractures and four nonunions were treated with the magnesium-based bioabsorbable compression screw MAGNEZIX Ò . Objective outcome was assessed by X-ray imaging and/or CT scan for bone healing. Clinical assessment was achieved using the modified Mayo Wrist Score. Patient-reported outcome measure was performed threefold via QuickDASH, PRWE, and EQ-5D-5L questionnaires in all patients. Follow-up was 32.5 months (SD 18.7) in the acute fracture group and 31 months (SD 7.4) in the nonunion group. Results Bone healing was achieved in all eight patients with acute scaphoid fractures and in three of four patients with scaphoid nonunion. The modified Mayo Wrist Score was 95 (SD 7.1) in fractures and 80 (SD 7.1) in nonunion patients during follow-up. QuickDASH score was 3.9 (SD 5.8) in fracture and 19.3 (SD 10.6) in nonunion patients. All but one patient (87,5%) with scaphoid fractures presented with a full health state during follow-up (EQ-5D-5L). Nonunion patients had problems in 10 out of 19 dimensions in EQ-5D-5L. Acute fractures presented with a score of 3.9 (SD 7.9) and nonunions with a score of 19.7 (SD 32.4) in PRWE total scoring during follow-up. Conclusions Magnesium-based implants have excellent clinical outcomes when used for scaphoid fractures in eight presented cases and good to moderate clinical outcomes when used for nonunions in three of four presented cases. Additional studies are required to further analyze the differentiated applicability in scaphoid nonunion as well as overall performance when compared to non-absorbable screws in larger cohorts.

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Bioabsorbable Implants

Abstract: Absorbable implants have become the hottest implant material, overtaking titanium as the future. Absorbable devices have moved beyond orthopedics and maxillofacial surgery to spine, vascular, plastics and general surgery. This chapter outlines the experiences of many specialties.

Cited by 11 publications

References 41 publications

Absorbable implants versus metal implants for the treatment of ankle fractures: A meta-analysis

Absorbable implants versus metal implants for the treatment of ankle fractures: A meta-analysis

The application of inferior vena cava filters in orthopaedics and current research advances

Magnesium‐Based Compression Screws in Acute Scaphoid Fractures and Nonunions

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