Bio-smart hydrogels: co-joined molecular recognition and signal transduction in biosensor fabrication and drug delivery

Brahim, Sean; Narinesingh, Dyer; Guiseppi‐Elie, Anthony

doi:10.1016/s0956-5663(02)00089-1

Cited by 132 publications

(77 citation statements)

References 22 publications

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“…The thickness and morphology of the film are primarily controlled by the amount of electric charge passed between the counter and working electrodes. Additionally, biofunctionality can be easily imparted to CPs during electrodeposition through the incorporation of biological entities such as silk-like protein fragments (SLPF) [59], hyaluronic acid (HA) [60,61], various laminin peptides [1,2,59,62], enzymes [28,[63][64][65][66], polymeric amino acids [67,68], growth factors [2,11,69,70] and whole cells [71]. Electrodeposition is the most commonly used method for coating conventional metallic bioelectrodes.…”

Section: Conventional Cp Fabricationmentioning

confidence: 99%

Conducting polymer-hydrogels for medical electrode applications

Green

Baek

Poole-Warren

et al. 2010

Science and Technology of Advanced Materials

236

175

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Conducting polymers hold significant promise as electrode coatings; however, they are characterized by inherently poor mechanical properties. Blending or producing layered conducting polymers with other polymer forms, such as hydrogels, has been proposed as an approach to improving these properties. There are many challenges to producing hybrid polymers incorporating conducting polymers and hydrogels, including the fabrication of structures based on two such dissimilar materials and evaluation of the properties of the resulting structures. Although both fabrication and evaluation of structure-property relationships remain challenges, materials comprised of conducting polymers and hydrogels are promising for the next generation of bioactive electrode coatings.

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Section: Conventional Cp Fabricationmentioning

confidence: 99%

Conducting polymer-hydrogels for medical electrode applications

Green

Baek

Poole-Warren

et al. 2010

Science and Technology of Advanced Materials

236

175

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“…Hydrogels prepared from poly[2-(dimethylamino) ethyl methacrylate)] (PDMAEMA) and its co-polymers have attracted much interest for their thermal and pH-stimuli responses [14][15][16][17]. PDMAEMA is a smart material which has been shown to be both temperature-and pH-critical at around 40 • C and 7.5, respectively [18,19].…”

Section: Introductionmentioning

confidence: 99%

Novel pH- and Temperature-Sensitive Behavior of Binary Graft DMAEMA/PEGMEMA onto LDPE Membranes

Hernández-Martínez

Bucio

2009

Designed Monomers and Polymers

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Low-density polyethylene membranes (LDPEs) were modified by the mutual grafting of 2-(dimethylamino) ethyl methacrylate (DMAEMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMEMA) using a direct method with gamma-rays. The effects of absorbed dose and monomer concentration were determined. The grafted samples were confirmed by Fourier transform infrared spectroscopy, thermal properties were analyzed by differential scanning calorimetry and thermogravimetric analysis, and the stimuli-responsive behavior and critical pH point were studied by swelling determination and measurement of the contact angle in water. pH-and thermo-responsive membranes of LDPE-g-DMAEMA/PEGMEMA exhibited a low critical solution temperature of 40 • C and critical pH point around 7.5.

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“…Glucose-sensitive hydrogels are attractive insulin carriers with novel technology. Podual [126] and Brahim et al [127].The swelling of hydrogel triggers the release of insulin when the local pH of the system reduces when glucose is converted to gluconic acid by glucose oxidase enzymes in the presence of oxygen. Glucose oxidase has been covalently attached to hydrogel network for controlling the release of insulin.…”

Section: Glucose-sensitive Hydrogelsmentioning

confidence: 99%

“…In these hydrogels, the hydrophobic amino acid groups of the coiled-coil proteins are used in physical crosslinking of gels as shown in Figure 6. Physically crosslinked protein-based hydrogels are composed of tri-block copolymers with coiled-coil domains at the end and water-soluble polypeptide domains in the center [127]. By modifying the amino acid sequences in coiled-coil domain stimuli sensitivity to temperature and pH can be achieved Moreover 3D structure of the hydrogel is also possible when water-soluble linear synthetic polymer coiled-coil proteins are used as crosslinkers [128].…”

Section: Protein-based Hydrogelsmentioning

confidence: 99%

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Raza

Zafar

Zhu

et al. 2017

Preprint

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Hydrogels evolved as an outstanding carrier material for local and controlled drug delivery that tend to the shortcomings of old conventional dosage forms for small drugs (NSAIDS) and large peptides and proteins. Aqueous swellable and crosslinked polymeric network structure of hydrogels is composed of various natural, synthetic and semisynthetic biodegradable polymers. Hydrogels have remarkable properties of functionality, reversibility, sterilizability, and biocompatibility. All these dynamic properties of hydrogels have increased the interest in their use as a carrier for peptides and proteins to be released slowly in a sustained manner. The therapeutical peptide and proteins are remarkable therapeutic agents in today's world that allows the treatment of severe, chronic and life-threatening diseases, such as diabetes, rheumatoid arthritis, hepatitis in an easy manner. Despite few limitations, hydrogels provide fine tuning of proteins and peptides delivery with enormous impact in clinical medicine. The primary objective of this article is to review current issues concerned with the therapeutics peptides and proteins and impact of remarkable properties of hydrogels on these therapeutic agents. Different routes for pharmaceutical peptides and proteins and superiority over other drugs candidates are presented. The article will also review literature concerning classification of hydrogels on different basis, polymers used, release mechanisms their physical and chemical characteristics and diverse applications.

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Bio-smart hydrogels: co-joined molecular recognition and signal transduction in biosensor fabrication and drug delivery

Cited by 132 publications

References 22 publications

Conducting polymer-hydrogels for medical electrode applications

Conducting polymer-hydrogels for medical electrode applications

Novel pH- and Temperature-Sensitive Behavior of Binary Graft DMAEMA/PEGMEMA onto LDPE Membranes

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

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