Bio-prototyping of europium-yttria based rods for radiation dosimetry

Santos, S.C.; Rodrigues, Orlando; Campos, L.L.

doi:10.1016/j.matchemphys.2017.07.063

Cited by 11 publications

(3 citation statements)

References 45 publications

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“…[ 1 , 2 ]. In particular, Europium (Eu) doped Y 2 O 3 has been intensively studied as scintillator for medical imaging, radiation detection and dosimetry [ 3 , 4 , 5 , 6 , 7 ]. Given the excellent scintillating properties that have been reported for this material, Souris et al [ 8 ] demonstrated that Y 2 O 3 :Eu NPs are promising materials for in situ, in vivo X-ray dosimetry.…”

Section: Introductionmentioning

confidence: 99%

Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

et al. 2021

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The innovative strategy of using nanoparticles in radiotherapy has become an exciting topic due to the possibility of simultaneously improving local efficiency of radiation in tumors and real-time monitoring of the delivered doses. Yttrium oxide (Y2O3) nanoparticles (NPs) are used in material science to prepare phosphors for various applications including X-ray induced photodynamic therapy and in situ nano-dosimetry, but few available reports only addressed the effect induced in cells by combined exposure to different doses of superficial X-ray radiation and nanoparticles. Herein, we analyzed changes induced in melanoma cells by exposure to different doses of X-ray radiation and various concentrations of Y2O3 NPs. By evaluation of cell mitochondrial activity and production of intracellular reactive oxygen species (ROS), we estimated that 2, 4, and 6 Gy X-ray radiation doses are visibly altering the cells by inducing ROS production with increasing the dose while at 6 Gy the mitochondrial activity is also affected. Separately, high-concentrated solutions of 25, 50, and 100 µg/mL Y2O3 NPs were also found to affect the cells by inducing ROS production with the increase of concentration. Additionally, the colony-forming units assay evidenced a rather synergic effect of NPs and radiation. By adding the NPs to cells before irradiation, a decrease of the number of proliferating cell colonies was observed with increase of X-ray dose. DNA damage was evidenced by quantifying the γ-H2AX foci for cells treated with Y2O3 NPs and exposed to superficial X-ray radiation. Proteomic profile confirmed that a combined effect of 50 µg/mL Y2O3 NPs and 6 Gy X-ray dose induced mitochondria alterations and DNA changes in melanoma cells.

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Section: Introductionmentioning

confidence: 99%

Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

et al. 2021

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“…The following starting materials were used: yttrium oxide (Y2O3, 99.99%, Alfa Aesar GmbH), europium oxide (Eu2O3, 99.999%, Alfa Aesar GmbH), nitric acid (HNO3, Synth), and ammonium hydroxide (NH4OH, Casa Americana). Synthesis of Y2O3:Eu powders was performed by hydrothermal process reported previously [15] . As synthesized nanoparticles were characterized by Photon Correlation Spectroscopy (PCS, ZetaPALS Analyzer, Brookhaven Instruments) [16]; x-ray diffraction (XRD, Rigaku Multiflex, Japan); and helium pycnometry (Pycnometer Micrometrics 1330.…”

Section: Methodsmentioning

confidence: 99%

“…As synthesized nanoparticles were characterized by Photon Correlation Spectroscopy (PCS, ZetaPALS Analyzer, Brookhaven Instruments) [16]; x-ray diffraction (XRD, Rigaku Multiflex, Japan); and helium pycnometry (Pycnometer Micrometrics 1330. Ceramic rods (4.35 x 2.27mm, height x diameter) formed by bio-prototyping [15] were characterized by XRD, SEM (Incact-X Oxford) and optical microscopy (OM, Nikon SMZ1270). Ceramic rods were irradiated with a gamma source with doses from 1Gy to 150kGy in ambient temperature.…”

Section: Methodsmentioning

confidence: 99%

Formation and EPR response of europium-yttria micro rods

Santos¹,

Júnior²,

Campos³

2019

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Designing new materials with suitable dose-response efficiency is a great challenge in radiation dosimetry search. Yttria (Y2O3) has excellent optical, mechanical, chemical, and thermal properties. Besides, yttria exhibits crystal characteristics that provide insertion of other rare earths, forming innovative materials. Nevertheless, there are quite few studies on formation, microstructural and EPR response evaluation of yttria. This work reports the formation and EPR characterization of europium-yttria micro rods for radiation dosimetry. Ceramic rods obtained by sintering at 1600ºC/4h in air were exposed to gamma radiation with doses from 1Gy to 150kGy. Particle, microstructural and dosimetry characterizations were performed by PCS, XRD, SEM, OM, and EPR techniques. As sintered europium-yttrium rods exhibited dense microstructure (90% theoretical density) and linear EPR dose response behavior up to 10kGy. These results show that europium-yttria is a promising material for radiation dosimetry.

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