Bio-Mimicking Nanoparticles for Targeted Therapy of Malignant Melanoma

Zhou, Xu; Yu, Ruilian; Cao, Xi; Zhang, Zhirong; Deng, Li

doi:10.1166/jbn.2019.2739

Cited by 23 publications

(16 citation statements)

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“…Similarly, celastrol-loaded PEG-PLGA nanoparticles coated with neutrophil membranes displayed significantly enhanced cytotoxicity and apoptosis rate in a murine melanoma cell line B16F10 compared to celastrolloaded PEG-PLGA nanoparticles (Zhou et al, 2019).…”

Section: Nanoparticlesmentioning

confidence: 92%

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

Shi

et al. 2020

Front. Pharmacol.

105

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Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits significant broad-spectrum anticancer activities for the treatment of a variety of cancers including liver cancer, breast cancer, prostate tumor, multiple myeloma, glioma, etc. However, the poor water stability, low bioavailability, narrow therapeutic window, and undesired side effects greatly limit its clinical application. To address this issue, some strategies were employed to improve the anticancer efficacy and reduce the side-effects of celastrol. The present review comprehensively focuses on the various challenges associated with the anticancer efficiency and drug delivery of celastrol, and the useful approaches including combination therapy, structural derivatives and nano/micro-systems development. The specific advantages for the use of celastrol mediated by these strategies are presented. Moreover, the challenges and future research directions are also discussed. Based on this review, it would provide a reference to develop a natural anticancer compound for cancer treatment.

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Section: Nanoparticlesmentioning

confidence: 92%

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

Shi

et al. 2020

Front. Pharmacol.

105

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“…[ 66 ] Based on the membrane composition of the NEs, biomimetic NPs and microparticles enveloped with the NEs’ membrane have the potential of targeting various conditions like acute inflammations, localized tumors, tumor metastasis, and sepsis. [ 66,74,122c,158 ]…”

Section: Whole Immune Cell Membrane or Its Proteins For Biomimetic Drmentioning

confidence: 99%

Chemically Engineered Immune Cell‐Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools

et al. 2021

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Over the past decades, considerable attention has been dedicated to the exploitation of diverse immune cells as therapeutic and/or diagnostic cell-based microrobots for hard-to-treat disorders. To date, a plethora of therapeutics based on alive immune cells, surface-engineered immune cells, immunocytes' cell membranes, leukocyte-derived extracellular vesicles or exosomes, and artificial immune cells have been investigated and a few have been introduced into the market. These systems take advantage of the unique characteristics and functions of immune cells, including their presence in circulating blood and various tissues, complex crosstalk properties, high affinity to different self and foreign markers, unique potential of their on-demand navigation and activity, production of a variety of chemokines/cytokines, as well as being cytotoxic in particular conditions. Here, the latest progress in the development of engineered therapeutics and diagnostics inspired by immune cells to ameliorate cancer, inflammatory conditions, autoimmune diseases, neurodegenerative disorders, cardiovascular complications, and infectious diseases is reviewed, and finally, the perspective for their clinical application is delineated.

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“…In addition, the novel nanoparticles as PTX nanocarrier also shows a high drug loading rate, which can store and release PTX slowly and for a long time. Moreover, Zhou et al reported PLGA nanoparticles coated with the membranes of neutrophils provided a biomimetic drug delivery system and achieved the target specificity for malignant melanoma [107]. As the most abundant leukocytes in the systemic circulation, neutrophils can be recruited at inflammatory sites under the action of the granulocyte colony stimulating factor in the tumor inflammatory microenvironment [108].…”

Section: Nanoparticle-mediated Chemotherapy Delivery For Melanoma Thementioning

confidence: 99%

Nanocarrier-Based Drug Delivery for Melanoma Therapeutics

Song

Liu

Chen

et al. 2021

IJMS

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Melanoma, as a tumor cell derived from melanocyte transformation, has the characteristics of malignant proliferation, high metastasis, rapid recurrence, and a low survival rate. Traditional therapy has many shortcomings, including drug side effects and poor patient compliance, and so on. Therefore, the development of an effective treatment is necessary. Currently, nanotechnologies are a promising oncology treatment strategy because of their ability to effectively deliver drugs and other bioactive molecules to targeted tissues with low toxicity, thereby improving the clinical efficacy of cancer therapy. In this review, the application of nanotechnology in the treatment of melanoma is reviewed and discussed. First, the pathogenesis and molecular targets of melanoma are elucidated, and the current clinical treatment strategies and deficiencies of melanoma are then introduced. Following this, we discuss the main features of developing efficient nanosystems and introduce the latest reports in the literature on nanoparticles for the treatment of melanoma. Subsequently, we review and discuss the application of nanoparticles in chemotherapeutic agents, immunotherapy, mRNA vaccines, and photothermal therapy, as well as the potential of nanotechnology in the early diagnosis of melanoma.

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Bio-Mimicking Nanoparticles for Targeted Therapy of Malignant Melanoma

Cited by 23 publications

References 0 publications

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application

Chemically Engineered Immune Cell‐Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools

Nanocarrier-Based Drug Delivery for Melanoma Therapeutics

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