Bio-Inspired Supramolecular Membranes: A Pathway to Separation and Purification of Emerging Pollutants

Nabeel, Faran; Rasheed, Tahir; Bilal, Muhammad; Li, Chuanlong; Yu, Chunyang; Iqbal, Hafiz M.N.

doi:10.1080/15422119.2018.1500919

Cited by 19 publications

(6 citation statements)

References 141 publications

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“…The inlet and outlet concentrations of this oxidant were measured using gas ozone analyzers (BMT 963 vent and BMT 964 vent, respectively). With the values measured by the gas ozone analyzers, transferred ozone dose (TOD), expressed in mgO 3 /L, could be determined using Equation (1), where the volume of effluent (2 L) used in the reactor is represented by V liquid , Q Gas is the gas flow rate (0.2 L/min), and [O 3 ] in and [O 3 ] out are the inlet and outlet ozone concentrations in the reactor, respectively [23].…”

Section: Experimental Procedures For Single and Catalytic Ozonationmentioning

confidence: 99%

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Removal of Enteric Pathogens from Real Wastewater Using Single and Catalytic Ozonation

Gomes

Frasson

Quinta‐Ferreira

et al. 2019

Water

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Water scarcity is one of the main problems of this century. Water reclamation appears as an alternative due to the reuse of treated wastewater. Therefore, effluents treatment technologies (activated sludge, rotary biological discs, percolating beds) must be improved since they are not able to remove emerging contaminants such as enteric pathogens (bacteria and virus). These pollutants are difficult to remove from the wastewater and lead to adverse consequences to human health. Advanced oxidation processes, such as single and catalytic ozonation, appear as suitable complements to conventional processes. Catalytic ozonation was carried out using a low-cost material, a volcanic rock. Single and catalytic ozonation were capable of promoting total Escherichia coli removal from municipal wastewater after 90 min of contact. The presence of volcanic rock increases disinfection efficiency since E. coli regrowth was not observed. The identified viruses (Norovirus genotype I and II and JC virus) were completely removed using catalytic ozonation, whereas single ozonation was not able to eliminate JC virus even after 150 min of treatment. The higher performance of the catalytic process can be explained by the formation of hydroxyl radicals, proving that disinfection occurs in the liquid bulk and not due to adsorption at the volcanic rock.

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Section: Experimental Procedures For Single and Catalytic Ozonationmentioning

confidence: 99%

“…The conventional wastewater treatment reveals difficulty in removing both chemical and biological emerging contaminants from water [1][2][3][4][5][6][7]. Among these pollutants, pharmaceutical and personal care products, as well as enteric pathogens [8][9][10][11][12], are of concern.…”

Section: Introductionmentioning

confidence: 99%

Removal of Enteric Pathogens from Real Wastewater Using Single and Catalytic Ozonation

Gomes

Frasson

Quinta‐Ferreira

et al. 2019

Water

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“…[365][366][367][368][369] Integration of biological processes with the state-of-the-art stimuli responsiveness of synthetic materials has helped understanding of the fundamental principles related to the biological processes. [370][371][372][373] However, natural processes operate under temporal regulation and are always associated with self-monitoring and self-correcting properties. [365][366][367][368][369][374][375][376] A true challenge emerges when considering dynamic transformations of synthetic gels by post assembly modification.…”

Section: Time Programmable Self-regulating Gel To Gel Transitionsmentioning

confidence: 99%

Stimuli responsive dynamic transformations in supramolecular gels

2021

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“…Isolating AA-2G from the reaction mixture has also been a complicated and challenging issue; this is partially due to low utilization efficiency of substrates, a small proportion of the target product (lower than 30%) in a complex mixture, and similar physicochemical and structural properties of byproducts, such as glucose, fructose, and different site-glycosylated products. Several bioseparation techniques have been applied in the current purification of AA-2G, such as column chromatography purification, , membrane technologies, and solvent extraction . However, scarce studies have been performed on the impurity formation mechanism and control methods in the manufacturing processes of AA-2G.…”

Section: Introductionmentioning

confidence: 99%

Identification of Process-Related Impurities and Corresponding Control Strategy in Biocatalytic Production of 2-O-α-d-Glucopyranosyl-l-ascorbic Acid Using Sucrose Phosphorylase

Zhou

Chen

et al. 2022

J. Agric. Food Chem.

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2-O-α-D-Glucopyranosyl-L-ascorbic acid (AA-2G) is an ideal substitute for L-ascorbic acid because of its remarkable stability and improved biological activity, which can be easily applied in cosmetic, food, and medicine fields. However, impurity identification and control are significant procedures during the manufacturing of AA-2G. This study assessed a manufacturing routine of AA-2G synthesized by sucrose phosphorylase (SPase). First, three unknown process-related impurities were observed, which were further identified as 3-O-α-D-glucopyranosyl-L-ascorbic acid (impurity I), 2-O-α-D-glucopyranosyl-L-dehydroascorbic acid (impurity II), and 13-O-α-D-glucopyranosyl-2-O-α-D-glucopyranosyl-L-ascorbic acid (impurity III), respectively. Second, a comprehensive formation pathway of impurities was elucidated, and specific strategies corresponding to controlling each impurity were also proposed. Specifically, the content of impurity I can be reduced by 50% by fine tuning reaction conditions. The impurity II-free purification process was also achieved by applying a low concentration of alkali. Finally, a semi-rational design was introduced, and a single mutant L343F was obtained by site-directed mutagenesis, which reduced impurities I and III by 63.9 and 100%, respectively, without affecting the transglycosylation activity. It is expected that the reported impurity identification and control strategies during the AA-2G production will facilitate its industrial production.

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Bio-Inspired Supramolecular Membranes: A Pathway to Separation and Purification of Emerging Pollutants

Cited by 19 publications

References 141 publications

Removal of Enteric Pathogens from Real Wastewater Using Single and Catalytic Ozonation

Removal of Enteric Pathogens from Real Wastewater Using Single and Catalytic Ozonation

Stimuli responsive dynamic transformations in supramolecular gels

Identification of Process-Related Impurities and Corresponding Control Strategy in Biocatalytic Production of 2-O-α-d-Glucopyranosyl-l-ascorbic Acid Using Sucrose Phosphorylase

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