Bio-inspired engineered ferritin-albumin nanocomplexes for targeted ferroptosis therapy

Xue, Chencheng; Zhang, Hui; Wang, Xuan; Du, Haoyu; Lu, Lu; Yang, Fei; Li, Yanan; Zhang, Yuchen; Li, Menghuan; Luo, Zhong

doi:10.1016/j.jconrel.2022.09.051

Cited by 10 publications

(4 citation statements)

References 51 publications

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“…On the one hand, ferritin can store iron; on the other hand, the Ferritin heavy chain is capable of specifically binds to the transferrin receptor 1 (TfR1), which is abundantly expressed on various kinds of tumor cells. In that case, NPs based on ferritin have the ability to target tumors 213 and improve the abundance of active iron species in tumor cells 206 . And more about this part can refer to Section 2.6 of this review.…”

Section: Np Technologiesmentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed to overcome different challenges and to achieve sophisticated delivery routes for enhancement of a series of therapies. Inspiring advances have been achieved in the field of cancer therapy using NPs. In this review, we aim to summarize the up‐to‐date progression of NPs for addressing various challenges, and expect to elicit novel and potential opportunities alternatively. We first introduce different sorts of NP technologies, illustrate their mechanisms, and present their applications. Then, the achievements made by NPs to break obstacles in delivering cargoes to specific sites through particular routes are highlighted, including long‐circulation, tumor targeting, responsive release, and subcellular localization. We subsequently retrospect recent research of NPs in different cancer treatments from single therapy, like chemotherapy, to combination therapy, like chemoradiotherapy, and to integrative therapy. Finally, the challenges and perspectives of NPs in cancer therapy, and their potential impact on the field of oncology are discussed. We believe this review can offer a deeper understanding of the challenges and opportunities of NPs for cancer therapy.

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Section: Np Technologiesmentioning

confidence: 99%

Advances and applications of nanoparticles in cancer therapy

Huang,

He,

Liang

et al. 2024

MedComm – Oncology

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“…Glutaraldehyde linker has been used to modify ferritin with motifs containing amino groups. For example, the reactive amino groups of ferritin and bovine serum albumin (BSA) both reacted with glutaraldehyde aldehyde groups to get ferritin and BSA covalent crosslinked by an acid-cleavable Schiff base bonds [ 85 ]. The product ferritin@BSA complexes showed significantly improved half-life, and could acid-responsively dissociate in lysosome.…”

Section: Functional Modifications Of Ferritin-based Nanoparticle Drug...mentioning

confidence: 99%

Ferritin-based nanomedicine for disease treatment

Zhu

Cao

et al. 2023

Medical Review

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Ferritin is an endogenous protein which is self-assembled by 24 subunits into a highly uniform nanocage structure. Due to the drug-encapsulating ability in the hollow inner cavity and abundant modification sites on the outer surface, ferritin nanocage has been demonstrated great potential to become a multi-functional nanomedicine platform. Its good biocompatibility, low toxicity and immunogenicity, intrinsic tumor-targeting ability, high stability, low cost and massive production, together make ferritin nanocage stand out from other nanocarriers. In this review, we summarized ferritin-based nanomedicine in field of disease diagnosis, treatment and prevention. The different types of drugs to be loaded in ferritin, as well as drug-loading methods were classified. The strategies for site-specific and non-specific functional modification of ferritin were investigated, then the application of ferritin for disease imaging, drug delivery and vaccine development were discussed. Finally, the challenges restricting the clinical translation of ferritin-based nanomedicines were analyzed.

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“…Both in vivo and in vitro data demonstrated that co-delivery of IONs and siR in the LDH nanocarrier effectively elevated cellular LPO stress and inhibited breast tumor growth with minimized damage to healthy tissues. In parallel with other nanomedicines (Table S3), mild therapeutic dosage, low injection times, and remarkable treatment efficiency make siR/IONs@LDH a potential strategy for clinical translation in cancer treatment. − …”

Section: Introductionmentioning

confidence: 99%

Synergistic Functional Nanomedicine Enhances Ferroptosis Therapy for Breast Tumors by a Blocking Defensive Redox System

Chen

Yang

Liang

et al. 2023

ACS Appl. Mater. Interfaces

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The upregulation of dihydroorotate dehydrogenase (DHODH) redox systems inside tumor cells provides a powerful shelter against lipid peroxidation (LPO), impeding ferroptosis-induced antitumor responses. To solve this issue, we report a strategy to block redox systems and enhance ferroptotic cancer cell death based on a layered double hydroxide (LDH) nanoplatform (siR/IONs@LDH) co-loaded with ferroptosis agent iron oxide nanoparticles (IONs) and the DHODH inhibitor (siR). siR/IONs@LDH is able to simultaneously release IONs and siR in a pH-responsive manner, efficiently generate toxic reactive oxygen species (ROS) via an Fe 2+ -mediated Fenton reaction, and synergistically induce cancer cell death upon the acceleration of LPO accumulation. In vivo therapeutic evaluations demonstrate that this nanomedicine has excellent performance for tumor growth inhibition without any detectable side effects. This work thus provides a new insight into nanomaterial-mediated tumor ferroptosis therapy.

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Bio-inspired engineered ferritin-albumin nanocomplexes for targeted ferroptosis therapy

Cited by 10 publications

References 51 publications

Advances and applications of nanoparticles in cancer therapy

Advances and applications of nanoparticles in cancer therapy

Ferritin-based nanomedicine for disease treatment

Synergistic Functional Nanomedicine Enhances Ferroptosis Therapy for Breast Tumors by a Blocking Defensive Redox System

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