Bio-inspired composite films with integrative properties based on the self-assembly of gellan gum–graphene oxide crosslinked nanohybrid building blocks

Ding, Kun; Cai, Zhixiang; Jin, Qiangwei; Zhang, Hongbin

doi:10.1016/j.carbon.2015.05.021

Cited by 44 publications

(24 citation statements)

References 82 publications

(97 reference statements)

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“…Rod-shaped AuNPs, known as "gold nanorods", show two LSPR bands that are defined as transverse and longitudinal bands. The transverse band is in the visible range of the spectrum, which is similar to that of a spherical AuNP, and longitudinal oscillation is in the NIR range of the spectrum (Herold et al, 2012;Yasun et al, 2012Yasun et al, , 2013Kang et al, 2015). The longitudinal band shifts to longer wavelengths (red shift) and shows stronger intensities when the aspect ratio increases.…”

Section: Background: Nanobiocolloidalsmentioning

confidence: 79%

Hybrid nanomaterial: biocolloidals

Gözübenli¹,

Yasun²,

Dilsiz³

2017

Turk J Biol

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Nanomaterials-based diagnostics have tremendous advantages over other conventional diagnostic systems in terms of sensitivity, specificity, and portability owing to the unique intrinsic properties of nanomaterials. Thus, there is a substantial need to develop and employ a broad spectrum of nanomaterials for biological and diagnostic applications. In this review, we focus on nanomaterials-assisted disease diagnosis utilizing different techniques such as photoluminescence, colorimetry, fluorescence, electrochemistry, microarray methods, surface plasmon resonance, and surface-enhanced Raman spectroscopy. In these techniques, different nanomaterials, including but not limited to gold and silver materials, metal oxides, and semiconductors, were employed according to their all-purpose chemical and physical properties. As the new properties of nanomaterials are discovered, their contributions to nanobiotechnology applications are vastly increased. In this review, the features of the selected nanobiomaterials, biological tag-modified nanomaterials, and their outstanding applications for the detection of specific biotargets have been summarized according to the latest studies. Nanomaterials contribute to the fields of photo/chemotherapy and biomedical imaging in particular, since all the biological events happen within this size range and beneficiary roles of nanoparticles (NPs) are countless in biomedical applications due to their unique physical and chemical properties. However, due to the necessity of specificity and selectivity, there is a clear ambition to study bioconjugation of NPs to increase the efficiency of the targeted biological applications. Thus, the combination of the specificity and the intrinsic properties of biohybrid NPs facilitate diagnostic and therapeutic applications.

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Section: Background: Nanobiocolloidalsmentioning

confidence: 79%

Hybrid nanomaterial: biocolloidals

Gözübenli¹,

Yasun²,

Dilsiz³

2017

Turk J Biol

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“…Since these films also had high biocompatibility, they show potential in tissue engineering and medical devices. [97] Finally, Mun et. al.…”

Section: Gellan Gum Filmsmentioning

confidence: 97%

“…Figure 5 shows the structure of prepared gellan gum-GO films. [97] Figure 5 demonstrates that hydrogen and coordinate bonds were found between gellan gum macromolecules and GO. The ionic and coordinate bonds are responsible for the high toughness of gellan gum/GO films.…”

Section: Gellan Gum Filmsmentioning

confidence: 99%

“…Fabrication of the bio-inspired gellan gum (GG)-GO nanocomposite film (reproduced with permission from ref. [97] 2015 Elsevier).…”

Section: Gelatin Filmsmentioning

confidence: 99%

“…In these studies rather than solution casting, other techniques were employed for the production of the films. Ultra-high strength nacre-like films were achieved by Hu et al [74] with wet spinning of alginate/GO films, by Kang et al [97] with vacuum filtration of gellan gum/GO films, by Liu et al [130] with vacuum assisted self-assembly of GO/PVA films and by Hu et al [109] with spin-assisted layer-by-layer technique for the formation of GO/SF membranes.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

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Graphene Oxide/Polymer‐Based Biomaterials

2017

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Since its discovery in 2004, derivatives of graphene have been developed and heavily investigated in the field of tissue engineering. Among the most extensively studied forms of graphene, graphene oxide (GO), and GO/ polymer-based nanocomposites have attracted great attention in various forms such as films, 3D porous scaffolds, electrospun mats, hydrogels, and nacre-like structures. In this review, the most actively investigated GO/ polymer nanocomposites are presented and discussed, these nanocomposites are based on chitosan, cellulose, starch, alginate, gellan gum, poly(vinyl alcohol) (PVA), poly(acrylamide), poly(e-caprolactone) (PCL), poly(lactic acid) (PLLA), poly(lactide-co-glycolide) (PLGA), gelatin, collagen, and silk fibroin (SF). The biological and mechanical performance of such nanocomposites are comprehensively scrutinized and ongoing research questions are addressed. The analysis of the literature reveals overall the great potential of GO/ polymer nanocomposites in tissue engineering strategies and indicates also a series of challenges requiring further research efforts.

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Graphene Oxide‐Doped Gellan Gum–PEGDA Bilayered Hydrogel Mimicking the Mechanical and Lubrication Properties of Articular Cartilage

Trucco

Vannozzi

Teblum

et al. 2021

Adv Healthcare Materials

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Articular cartilage (AC) is a specialized connective tissue able to provide a low‐friction gliding surface supporting shock‐absorption, reducing stresses, and guaranteeing wear‐resistance thanks to its structure and mechanical and lubrication properties. Being an avascular tissue, AC has a limited ability to heal defects. Nowadays, conventional strategies show several limitations, which results in ineffective restoration of chondral defects. Several tissue engineering approaches have been proposed to restore the AC's native properties without reproducing its mechanical and lubrication properties yet. This work reports the fabrication of a bilayered structure made of gellan gum (GG) and poly (ethylene glycol) diacrylate (PEGDA), able to mimic the mechanical and lubrication features of both AC superficial and deep zones. Through appropriate combinations of GG and PEGDA, cartilage Young's modulus is effectively mimicked for both zones. Graphene oxide is used as a dopant agent for the superficial hydrogel layer, demonstrating a lower friction than the nondoped counterpart. The bilayered hydrogel's antiwear properties are confirmed by using a knee simulator, following ISO 14243. Finally, in vitro tests with human chondrocytes confirm the absence of cytotoxicity effects. The results shown in this paper open the way to a multilayered synthetic injectable or surgically implantable filler for restoring AC defects.

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Bio-inspired composite films with integrative properties based on the self-assembly of gellan gum–graphene oxide crosslinked nanohybrid building blocks

Cited by 44 publications

References 82 publications

Hybrid nanomaterial: biocolloidals

Hybrid nanomaterial: biocolloidals

Graphene Oxide/Polymer‐Based Biomaterials

Graphene Oxide‐Doped Gellan Gum–PEGDA Bilayered Hydrogel Mimicking the Mechanical and Lubrication Properties of Articular Cartilage

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