Bio-guided fractionation of the antimutagenic activity of methanolic extract from the fruit of Randia echinocarpa (Sessé et Mociño) against 1-nitropyrene

Cano-Campos, M.C.; Díaz‐Camacho, Sylvia Páz; Uribe-Beltrán, M.J.; López‐Ángulo, Gabriela; Montes‐Ávila, Julio; Paredes‐López, Octavio; Delgado‐Vargas, Francisco

doi:10.1016/j.foodres.2011.08.006

Cited by 18 publications

(21 citation statements)

References 29 publications

(33 reference statements)

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“…Antimutagenicity was evaluated by the Ames microsuspension assay, as described by Cano-Campos et al. ( 2011 ), using the tester strain Salmonella enterica serovar typhimurium YG1024 and 1-nitropyrene (1-NP) as mutagen. The toxicity and mutagenicity of the ME were evaluated up to 1 mg/tube.…”

Section: Methodsmentioning

confidence: 99%

Chemical composition and biological activities of Helicteres vegae and Heliopsis sinaloensis

Olivas-Quintero

López‐Ángulo

Montes‐Ávila

et al. 2017

Pharmaceutical Biology

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Context:Helicteres vegae Cristóbal (Sterculiaceae) (Hv) and Heliopsis sinaloensis B.L. Turner (Asteraceae) (Hs) are endangered and poorly studied plant species; related plants have been used against chronic-degenerative and infectious diseases. Therefore, Hv and Hs could be sources of bioactive compounds against these illnesses.Objective: To determine the chemical composition and biological activities (antioxidant, antimutagenic and antimicrobial) of Hv and Hs leaves (L) and stems (S).Materials and methods: Methanol extracts (ME) of each plant/tissue were evaluated for their phytochemicals; phenolics (HPLC-DAD-ESI-MS); antioxidant activity (AA) (0.125–4 mg/mL) (DPPH, ABTS, ORAC and β-carotene discoloration); antimutagenicity (0.5 and 1 mg/plate) (Ames assay, tester strain Salmonella enterica serovar Typhimurium YG1024, 1-nitropyrene as mutagen); activity against human pathogens (1 mg/mL); and toxicity (0.01–2 mg/mL) (Artemia salina assay).Results: All ME showed flavonoids and triterpenes/steroids. The ME-SHv had the highest content of total phenolics (TP) (2245.82 ± 21.45 mg GAE/100 g d.w.) and condensed tannins (603.71 ± 1.115 mg CE/100 g d.w.). The compounds identified were flavonoids (kaempferol 7-O-coumaroylhexoside, and two kaempferol 7-O-rhamnosylhexosides) and phenolics [rosmarinic acid, and 3′-O-(8″-Z-caffeoyl) rosmarinic acid]. The ME-LHs showed the highest content of flavonoids (357.88 mg RE/g d.w.) and phenolic acids (238.58 mg CAE/g d.w.) by HPLC. The ME-SHv showed the highest AA. All ME were strong antimutagens (63.3-85.7%). Only the Hs extracts were toxic (ME-LHs, LC50 = 94.9 ± 1.7 μg/mL; ME-SHs, LC50 = 89.03 ± 4.42 μg/mL).Discussion and conclusions: Both Hv and Hs are potential sources of preventive and therapeutic agents against chronic-degenerative diseases.

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Section: Methodsmentioning

confidence: 99%

Chemical composition and biological activities of Helicteres vegae and Heliopsis sinaloensis

Olivas-Quintero

López‐Ángulo

Montes‐Ávila

et al. 2017

Pharmaceutical Biology

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“…The edible fruit is known for its immense ethno pharmacological relevance under various diseased conditions. Its hexane fraction displayed significantly strong antimutagenic activity in S. typhimurium YG1024 through micro suspension assay when 1-nitropyrene was used as mutagen [121]. In this study highest antimutagenicity was attributed to the presence of sterols (predominantly campesterol and β-sitosterol) and fatty acids (palmitic and linoleic).…”

Section: Randia Echinocarpamentioning

confidence: 62%

Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

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Mutation is the process leading to heritable changes in the genetic material of an organism and caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA replication, repair, and recombination. Agents contributing to the mutagenic burden in the environment could be from industrial sources, wide spectrum applications of biocides in the agriculture, and other contaminants. As many of these mutagenic chemicals can induce severe disorders in humans including cancer and a large spectrum of inherited diseases, it is important to detect such mutagenic agents precisely and rapidly, and also look for an approach to combat them. Natural occurring dietary antimutagens primarily from health protective foods such as fruits and vegetables could provide a mechanism to counteract the deleterious effect of these mutagens. The World Health Organization (WHO) indicates that one-third of all cancer deaths are preventable and that diet is closely linked to cancer prevention. These health protective phytochemicals particularly antimutagenic ones could provide an effective solution to these concerns. The current review deals with understanding of the mutagenic events, methods of its analysis and a brief compilation of the existing scientific findings related to the dietary sources having potential to counteract the effects of the mutagenic exposures from different sources. The review would provide an opportunity to look into the science, think about the possible future perspectives and mechanism to translate the outcome of the scientific research for benefits of the mankind.

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“…The removal of solvent can be done either by N 2 blowing until reaching a constant weight or by rotary evaporation if non-polar extractant is used. Otherwise, the freeze-drying method is available for the polar solvent (Cano-Campos et al, 2011). Solvent removal is critical because of its bactericidal against tested bacteria (Table 2), and omission of this step may lead to false-positive result (Torres, Pandey, and Castro, 2011).…”

Section: Preparation Of Samplementioning

confidence: 99%

Antibacterial test and toxicity of plant seed extracts: a review

Sowhini¹,

Sani²,

Hashim³

et al. 2020

Food Res.

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Allah has instructed all humankind to eat permissible healthy food according to His guidance as narrated in Al-Quran. Following Maqasid as-Shari’ah, it is a Darruriyyah to ensure the safety of food as an act of protecting life. Therefore, the application of antibacterial agent on food aims to improve the consumers’ health and control the herd immunity. Plant seed is a newly emerged alternative as a source of antibacterial agents. Commonly discarded, the utilisation of plant seed will not only reduce environmental waste issue but also benefited economically to many industries. This article was aimed to review the current literature on antibacterial test and toxicity of various plant seed extracts that potentially contributed to the efficacy of the seed. This review presents a comprehensive analysis of the antibacterial activity assay of the plants' seeds. It covers endpoint and descriptive methods, plant seed toxicity and application of the seed extract in food industries. This review was conducted using the various science-based platform such as Science Direct, Google Scholar, Emerald etc. The keywords ‘antibacterial’, ‘antibacterial seed’, ‘seed extract’ and ‘toxicity seed’ was used in this search.

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Bio-guided fractionation of the antimutagenic activity of methanolic extract from the fruit of Randia echinocarpa (Sessé et Mociño) against 1-nitropyrene

Cited by 18 publications

References 29 publications

Chemical composition and biological activities of Helicteres vegae and Heliopsis sinaloensis

Chemical composition and biological activities of Helicteres vegae and Heliopsis sinaloensis

Fruits and Vegetables as Dietary Sources of Antimutagens

Antibacterial test and toxicity of plant seed extracts: a review

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