Bio-functionalization of silicon nitride-based piezo-resistive microcantilevers

Kale, Nitin S.; Joshi, Manjunath V.; Rao, P. Nageswara; Mukherji, Soumyo; Rao, V. Ramgopal

doi:10.1007/s12046-009-0036-7

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…Sometimes multiple layers of linking molecules are utilised to increase the bonding strength. Biotin-streptavidin [19,20], antibody-antigens [21][22][23] and aptamers [24,25] are among the most commonly used molecule pairs for surface functionalisation studies. Furthermore, using self-assembled-monolayers (SAMs) is becoming a popular choice in the recent literature [26][27][28] as well as sandwich-type surface functionalisation and nanomaterials [17,29].…”

Section: Terminology and Trendsmentioning

confidence: 99%

Biosensors in the small scale: methods and technology trends

Senveli

Tigli

2013

IET nanobiotechnol.

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This study presents a review on biosensors with an emphasis on recent developments in the field. A brief history accompanied by a detailed description of the biosensor concepts is followed by rising trends observed in contemporary micro- and nanoscale biosensors. Performance metrics to quantify and compare different detection mechanisms are presented. A comprehensive analysis on various types and subtypes of biosensors are given. The fields of interest within the scope of this review are label-free electrical, mechanical and optical biosensors as well as other emerging and popular technologies. Especially, the latter half of the last decade is reviewed for the types, methods and results of the most prominently researched detection mechanisms. Tables are provided for comparison of various competing technologies in the literature. The conclusion part summarises the noteworthy advantages and disadvantages of all biosensors reviewed in this study. Furthermore, future directions that the micro- and nanoscale biosensing technologies are expected to take are provided along with the immediate outlook.

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Section: Terminology and Trendsmentioning

confidence: 99%

Biosensors in the small scale: methods and technology trends

Senveli

Tigli

2013

IET nanobiotechnol.

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“…Immobilisation layer is applied over the structural layer of biosensing cantilevers which are used to sense the chemical substances, antibodies, explosives etc. The immobilisation layer is a chemical which reacts with the required analyte e.g., Palladium coating absorbs hydrogen and expands [10,11], Myoglobin antibody is used to detect myoglobin [12].…”

Section: Materials and Manufacturing Aspecfsmentioning

confidence: 99%

“…This paper, with a in detail in this paper. comprehensive list of references (104 references were listed), dealt with various aspects of cantilever based Biofunctionalization microcantilevers with sensors such as methods of use, method of secondary silicon nitride based piezoresistive element is transduction, biosensing applications and a future presented in [12]. The schematic of the piezoresistive direction.…”

Section: Applications In Sensorsmentioning

confidence: 99%

Nano/Micro-Electro-Mechanical Systems for Sensor Applications: A Brief Review

Subrahmanyam

Rao

Ramamurthy

et al. 2010

IETE Journal of Education

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“…At present, there seems to be some obstacles to realize full potential of cantilever‐based biosensor. Firstly, instead of complex and expensive optical method for measuring the deflection of cantilever 6–9, electrical method has been developed by fabricating the cantilever with the silicon (or silicon compound) piezoresistance, where the deflection can be translated into electrical signal for simple and easy measurements 10–13. However, it has been found that the signal of p + ‐Si piezoresistance is not stable during measurement due to its high temperature coefficient of resistance (TCR) 14.…”

Section: Introductionmentioning

confidence: 99%

A Micromechanical Cantilever‐Based Liposome Biosensor for Characterization of Protein‐Membrane Interaction

et al. 2015

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1IntroductionIn the past years,p hospholipid bilayer vesicles,n amely liposomes,h ave been useda sm odel cell membranes to investigate the manner and mechanism of the proteinmembrane interactions [1][2][3][4][5].A st he research on proteinmembrane interaction is of greati mportance in the fields of biology,m edical care,a griculture and so on, the developmento fn ovel technologies for simple,f ast and lowcost characterization of protein-membranei nteraction withoutl abeling is significantly required. Recently,m icrocantilever sensors have attracted increasing attention for biomedical applications [6][7][8][9][10][11][12][13].H owever, there are few literatures reporting label-free evaluation of proteinmembrane interaction using micro-cantilever. As the principle of micro-cantilever biosensor is that targetb iomolecules are detectedb ym easuring the deflection of cantilever caused by the interaction betweent he sensing biomolecules immobilizedo nt he cantilever and target biomolecules [6],w ec onsidert hat it is as uitable device for characterization of protein-membrane interaction. Therefore,w ea ttempt to establish ae ffective evaluation system for characterization of variousp rotein-membrane interactions based on amicro-cantilever biosensor.At present, there seems to be some obstaclest or ealize full potential of cantilever-based biosensor. Firstly,i nstead of complex and expensive optical method for measuring the deflection of cantilever [6][7][8][9],e lectricalm ethod has been developed by fabricating the cantilever with the silicon (or silicon compound) piezoresistance,w here the deflection can be translated into electricals ignal for simple and easy measurements [10][11][12][13].H owever,i th as been found that the signal of p + -Si piezoresistancei sn ot stable during measurement due to its high temperature coefficient of resistance (TCR) [14].T herefore,f urther improvementi nt he electrical method for measuring the deflection of cantilever is necessary.S econdly,t here exist two waysi np rinciple for detectioni nl iquid;o ne is as taticm easurement by immersing the cantilever in an opened large liquidc ell (0.8-10 mL) filled with target protein solution [8,11],a nd the other is ad ynamic measurement in the fluid solution which flowst hroughacell and is controlled by ap ump [6,7,13].H owever,t he both methodsr equire large amounts of reagents.I np articular, the fluid liquid mentioned in the dynamic methodm ay have more influence on the stability and accuracyo fm easurement thant he static one if the liquid flow is not precisely controlled. Furthermore,t he influence of solution evaporation on the stability of liquid condition is another serious obstacle. In order to further improve the performance of microcantilever biosensor, some modifications 1) insertion of NiCr thin film strain gauge in the cantilever instead of silicon piezoresistance and 2) fabrication of an ew dropletsealing structure on the cantilever sensor, have been attempted [15].T ob es pecific, for 1), as it has been confirmed that TCR of ...

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Bio-functionalization of silicon nitride-based piezo-resistive microcantilevers

Cited by 5 publications

References 5 publications

Biosensors in the small scale: methods and technology trends

Biosensors in the small scale: methods and technology trends

Nano/Micro-Electro-Mechanical Systems for Sensor Applications: A Brief Review

A Micromechanical Cantilever‐Based Liposome Biosensor for Characterization of Protein‐Membrane Interaction

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