Bio-engineered nano-vesicles for IR820 delivery: a therapy platform for cancer by surgery and photothermal therapy

Zhang, Xiaojie; Zhou, Changsheng; Wu, Fanghua; Gao, Chang; Liu, Qianqian; Lv, Peng; Li, Ming; Huang, Liyong; Wu, Ting; Li, Wengang

doi:10.1039/d1nr05601h

Cited by 6 publications

(6 citation statements)

References 56 publications

(71 reference statements)

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“…323 Due to the target delivery of cell membrane nanoparticles, multifunctional modification strategies based on cell membrane biomimetic nanoparticles include noncovalent coating and chemical modification. [324][325][326] Due to the biocompatibility of the cell membrane, the cell membrane can be coated on the photothermal materials to form a core-shell structure, such as Pt, Au, 327 IR780, 328 and IR820 329 . For example, Zhai et al 330 prepared a traceable bioinspired nanovesicle (MPV) based on a cell membrane-derived shell.…”

Section: Cell Membrane Biomimetic Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Section: Cell Membrane Biomimetic Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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“…[ 122 ] Taken one step further, IR820 is usually encapsulated in nanostructures (such as inorganic Fe@CaCO 3 and organic nanocapsules), further delivering it to the tumor area through targeted delivery and high‐concentration accumulation, as well as it can be utilized as a multimodal reagent in imaging and clinical application during low infrared light (808 nm laser, 1.0 W·cm −2 ). [ 123,124 ] The strong drug toxicity makes IR820 induce the heat‐lethal effect of liver cancer both in vivo and in vitro, in which mild PTT‐induced local hyperthermia kills immunogenic cells, resulting in hypersensitivity of tumors to immune checkpoint inhibitors, thereby improving the efficiency of HCC hyperthermia.…”

Section: Different Ptas Commonly Used In Ptt Toward Hccmentioning

confidence: 99%

Section: Combinational Photothermal Therapy and Other Therapy Toward Hccmentioning

confidence: 99%

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Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

Yan

Liu

et al. 2023

Adv Funct Materials

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Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is a treatment strategy that utilizes near‐infrared (NIR) light‐induced photothermal agents (PTAs) to yield photothermal effects to localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks to timely summarize and highlight the recent progress of PTAs used for photothermal treatment of liver cancer in vivo and in vitro in the last five‐year. The implications of various PTAs on the multifunctional photothermal conversion capability, the structure‐performance correlations of PTT, together with the evaluation of their potential in application are systematically dissected to further dig out what the buried mechanism is. Besides, higher requirements are put forward for the discrepancies and crucial issues faced by different PTAs in PTT with related medical technical obstacles being conquered, which lays a solid theoretical foundation for the medical field of oncology treatment as a whole, especially liver cancer. Finally, it is expected that this review can present valuable guidance for the design of efficient, photostability, and biosafety‐aware PTAs for anticancer therapy while stepping into the fast traffic lane for the conversion from bench to bedside in the foreseeable future.

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“…The design and preparation of multifunctional nanoplatforms with integrated functions have aroused extensive interest among nanobiotechnologists. Recently, an increasing number of diagnostic nanoprobes have been developed based on inorganic, organic, and organic/inorganic nanomaterials for image-guided photodynamic therapy (PTT), photothermal therapy (PDT), and acoustic therapy of cancer. − In addition to these laser or ultrasound-mediated therapies, there are also chemodynamic therapy (CDT) that produce singlet states to kill tumor cells by Fenton or Fenton-like reaction in the presence of H 2 O 2 . , The surface functional groups of these nanomaterials ( e.g. , inorganic materials) are relatively easy to modify, which can be used to encapsulate drugs and are equipped with a variety of imaging/healing properties. − Although they have excellent therapeutic efficacy in animal models, their inherent low biodegradation is a serious obstacle to their clinical use.…”

Section: Introductionmentioning

confidence: 99%

Manganese Dioxide/Gold-based Active Tumor Targeting Nanoprobes for Enhancing Photodynamic and Low-Temperature-Photothermal Combination Therapy in Lung Cancer

Liu,

Huang,

et al. 2023

ACS Appl. Mater. Interfaces

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Tumor drug resistance caused by the tumor microenvironment is an extremely difficult problem for researchers to solve. Nanoplatforms that integrate diagnosis and treatment have great advantages in tumor treatment, but the design and synthesis of simple and efficient nanoplatforms still face tremendous challenges. In this study, a novel Mn/Au@ir820/GA-CD133 nanoprobe was developed. The manganese dioxide/gold particles were prepared by coprecipitation/ assembly, chemically coupled with CD133 antibody, and finally loaded with the photosensitive drug IR820 and the heat shock protein inhibitor Ganetespib. The nanoprobe demonstrated good tumor-targeting ability, increased the level of singlet oxygen produced from laser irradiation by effectively alleviating tumor hypoxia, and decreased the threshold of heat tolerance by downregulating the expression of HSP90 in tumor tissues. This nanoprobe successfully inhibited the growth and progression of tumor tissues in a tumor-bearing mouse model by improving the effectiveness of photodynamic and low-temperature photothermal combination therapy.

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Bio-engineered nano-vesicles for IR820 delivery: a therapy platform for cancer by surgery and photothermal therapy

Abstract: Long-term unsolved health problems from pre-/Intra-/postoperative complications and thermal ablation complications pose threats to liver cancer patients. To reduce the threats, we propose a multimodal-imaging guided surgical navigation system...

Cited by 6 publications

References 56 publications

Multifunctional nanoparticle for cancer therapy

Multifunctional nanoparticle for cancer therapy

Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

Manganese Dioxide/Gold-based Active Tumor Targeting Nanoprobes for Enhancing Photodynamic and Low-Temperature-Photothermal Combination Therapy in Lung Cancer

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