Bio-efficacy of organic selenium compounds in broiler chickens

Abstract

This study is aimed at comparing the bio-efficacy of different inorganic and organic Se compounds. Three broiler experiments (Exp1 ¼ Ross PM3; Exp2 ¼ Ross 308; and Exp3 ¼ Ross 308) were performed, on the basis of Se tissue accretion, to define the bio-efficacy of Se sources. Birds were fed a control diet (negative control [NC]; no supplemental Se) and, depending on the study, the NC was supplemented with sodium selenite (SS), Se-yeast (35%, 56%, 65% or 72% of Se as selenomethionine (SeMet); SY35, SY56, SY65 and SY72), pure forms of selenocysteine (SeCys) (methylselenocysteine [MSeCys]; L-selenocystine [L-SeCys]), or pure form of organic Se (L-selenomethionine, L-SeMet or hydroxy-selenomethionine, OH-SeMet) at 0.3 mg Se/kg. In Exp 2, an additional treatment of SY65 þ L-SeCys was also fed, with both sources added at 0.3 mg Se/kg. In Exp3, L-SeMet and OH-SeMet, were supplemented at 0.15, 0.30, 0.45 and 0.60 mg Se/kg. The results of Exp 1 (mg Se/kg muscle DM

Hydroxy-Selenomethionine Improves the Selenium Status and Helps to Maintain Broiler Performances under a High Stocking Density and Heat Stress Conditions through a Better Redox and Immune Response

“…These results confirm previous observations whereby OH-SeMet maintained a better FCR in broilers [33] than SS or SY, under heat stress conditions, as well as in egg production and FCR in layers [34] and in the milk yield of dairy cows [35]. These findings confirm that the two organic Se sources OH-SeMet and SY are not equivalent and that, more than the total Se of those sources, it is their SeMet proportion that mainly drives their efficacy [25].…”

“…The hierarchy of efficacy of these Se sources was also confirmed by the Se concentrations in the muscles, as has already been described for cases in which pure organic Se forms of OH-SeMet have a higher bioavailability than SY or SS [12,25]. This efficacy supports the concept that organic Se forms, thanks to the storage of SeMet in the tissues, can constitute a reservoir of Se that becomes available in challenging situations (eg.…”

“…This efficacy supports the concept that organic Se forms, thanks to the storage of SeMet in the tissues, can constitute a reservoir of Se that becomes available in challenging situations (eg. heat stress) and confirms the superiority of OH-SeMet over SY for a higher storage depot of Se [25,26]. Such a reservoir of Se in heat stress conditions, which may result in increased oxidative stress and a lower availability of feed nutrients due to a limitation of the feed intake, could explain the ability of OH-SeMet to help animals maintain or increase the synthesis of selenoproteins and, therefore, to better support endogenous redox systems, which help to maintain the performance, growth, feed efficiency and overall health and welfare status of animals [17].…”

“…To date, the functional benefits of OH-SeMet, compared to both SS and SY, have been described for dairy cows [18,19], swine [20,21], layers [22,23] and broilers [24,25]. Furthermore, it has been demonstrated that OH-SeMet has a unique ability to increase the deposition of Se in the tissues of broilers and to significantly increase the expression and translation of several selenoproteins compared to SS and SY [26].…”

Hydroxy-selenomethionine enhances the productivity and egg quality of 50- to 70-week-old semi-heavy laying hens under heat stress

“…Increased tissue reserves of Se can enhance the resistance of livestock to stress and diseases, and therefore represent a key strategy to help fight commercially relevant forms of stress, such as heat stress and aging. Studies have shown that OH-SeMet increases the tissue deposition of Se in farm animals more than SS and SY ( Briens et al, 2013 ; Jlali et al, 2013 ; Zhao et al, 2017 ; Marco et al, 2021 ). Moreover, it has been shown that this higher storage capacity is translated into a higher gene expression and activity of several selenoproteins that play pivotal roles in antioxidant defense ( Zhao et al, 2017 ; Sun et al, 2021 ).…”