Bio-effects of Nano-TiO2 on DNA and cellular ultrastructure with different polymorph and size

Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells

“…0.4 g/mL). Zhu et al [21] also observed a dosedependent cytotoxic effect at 25-325 g/mL concentration range for 24 h exposure. Consequently, former reports are not conflicting with the latter ones or results here presented, since 3 and 4 h exposure periods may not be long enough to detect genotoxic effects, indicating that the response is also dependent on the exposure time.…”

“…Theogaraj et al [16] and Warheit et al [17] did not find TiO 2 NPs to be genotoxic since they did not observe DNA damage frequency increase after the chromosomal aberration test in CHO cells. Conversely, Nakagawa et al [18], Lu et al [19], Uchino et al [20], and Zhu et al [21] found toxic effects of TiO 2 on this cell line. However, in some cases NPs used were not characterized.…”

Bioavailability, Toxicity, and Fate of Manufactured Nanomaterials in Terrestrial Ecosystems

“…Complicating the ability to develop unifying principles for predicting the interactions with and toxicity of MNMs to ecoreceptors has been the great diversity of MNM composition and surface functionality, as well as the diversity of receptor species exposed. Each MNM has a set of intrinsic properties, such as composition, crystal structure, size, shape, and surface chemistry that may affect mobility, bioavailability, and toxicity (Chithrani et al, 2006;Jia et al, 2005;Magrez et al, 2006;Zhu et al, 2009). In most cases, these properties will also vary within a single sample of MNMs.…”

The mechanism of oxidative damage in the nephrotoxicity of mice caused by nano-anatase TiO2

“…Furthermore, Zhu et al [25] showed that 10-20 nm anatase TiO 2 causes stronger cytotoxicity on CHO cells and 293T cells than does 50-60 nm anatase TiO 2 , which is stronger than 50-60 nm rutile. TiO 2 can be classified into three types: anatase, rutile and amorphous.…”