Bio-based polyurethane for tissue engineering applications: How hydroxyapatite nanoparticles influence the structure, thermal and biological behavior of polyurethane composites

Gabriel, Laís Pellizzer; Santos, Maria Elizabeth M. dos; Jardini, André Luiz; Bastos, Gilmara N. T.; Dias, Carmen Gilda Barroso Tavares; Webster, Thomas J.; Filho, Rubens Maciel

doi:10.1016/j.nano.2016.09.008

Cited by 39 publications

(31 citation statements)

References 30 publications

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“…Co-polymerization directly changes chemical properties that influence other properties indirectly. In comparison with blending, it changes physical as well as chemical properties and the biodegradation rate [ 77 ]. Blending PCL with bioactive glass and bioceramics, such as HAp, can improve hydrophilicity and bioactivity of scaffolds.…”

Section: Methodsmentioning

confidence: 99%

“…Polyurethanes (PU), a major class of synthetic elastomers [ 78 ], are products of reaction of molecules with two or more hydroxyl groups and molecules containing two or more isocyanate groups. Two thermodynamic incompatible phases can be obtained [ 77 ]. Polyester chains comprise the soft segments, while the hard segments are composed of polyurethane blocks on aromatic isocyanates, providing non-biocompatibility due to the toxic degradation products.…”

Section: Methodsmentioning

confidence: 99%

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Fabrication of Scaffolds for Bone-Tissue Regeneration

2019

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The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. Strategies and materials used in oral regenerative therapies correspond to techniques generally used in bone tissue engineering. Researchers are focusing on developing and improving new materials to imitate the native biological neighborhood as authentically as possible. The most promising is a combination of cells and matrices (scaffolds) that can be fabricated from different kinds of materials. This review summarizes currently available materials and manufacturing technologies of scaffolds for bone-tissue regeneration.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Fabrication of Scaffolds for Bone-Tissue Regeneration

2019

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“…PUs can be obtained as a foams [1], elastomers [2,3], thermoplastics [4], coatings [5], as well as fibers [6,7]. It is also possible to use polyurethanes as a component for preparing polymer composites [8] or blends [9,10]. Generally, the synthesis of PUs is carried out using one-or two-step method.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, structure and properties of poly(ester-urethane)s obtained using bio-based and petrochemical 1,3-propanediol and 1,4-butanediol

Datta

Kasprzyk

Błażek

et al. 2017

J Therm Anal Calorim

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In this paper, the poly(ester-urethane)s obtained using petrochemical and bio-based chain extenders were prepared and characterized. The influence of glycols' origin on the chemical structure, mechanical and thermal properties of the prepared polyurethanes was studied. The materials were synthesized by prepolymer method. The first step involved the reaction of a,x-dihydroxy(ethylenebutylene adipate) (POLIOS 55/20) with 4,4 0 -diphenylmethane diisocyanate (MDI). In the next step, obtained prepolymer terminated with isocyanate group was extended using 1,3-propanediol and 1,4-butanediol at three different molar ratios of NCO group (presented in prepolymer chains) to OH groups (presented in chain extender structure), i.e., 0.95, 1.0 and 1.05. The results showed that applying the different types (diversified chemical structure and origin) of glycols results in obtaining materials with diversified mechanical properties and slight different thermal stabilities. The results of Fourier transform infrared spectroscopy showed that the chemical structure of the obtained polyurethanes was not affected by the presence of glycols with the same chemical structure and different origins (petrochemical and bio-based nature).

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“…Biocompatible synthetic polymers are suitable candidates for membrane application as they exhibit biodegradability, biocompatibility, non‐toxicity, and excellent mechanical properties (e.g., moderate tensile strength and Young's modulus, and good abrasion and tear resistance). Most commonly used synthetic polymers for membrane development include polycaprolactone (PCL), [ 92,105–107 ] polyurethanes, [ 108,109 ] poly(lactide‐co‐glycolide)‐b‐poly(ethylene glycol)‐b‐poly(lactide‐co‐glycolide) (PELGA), [ 110 ] poly(L‐lactic acid) (PLLA), [ 111 ] polylactic(L‐lactic‐co‐glycolic acid) (PLGA), [ 112 ] and poly(ethylene glycol) (PEG). [ 113,114 ] Electrospinning is an effective method for the development of nanofibrous TEP using synthesized polymer with similar properties as native ECM.…”

Section: Different Materials For Constructing Tep Scaffoldsmentioning

confidence: 99%

Periosteal Tissue Engineering: Current Developments and Perspectives

Lou

Wang

et al. 2021

Adv Healthcare Materials

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Periosteum, a highly vascularized bilayer connective tissue membrane plays an indispensable role in the repair and regeneration of bone defects. It is involved in blood supply and delivery of progenitor cells and bioactive molecules in the defect area. However, sources of natural periosteum are limited, therefore, there is a need to develop tissue‐engineered periosteum (TEP) mimicking the composition, structure, and function of natural periosteum. This review explores TEP construction strategies from the following perspectives: i) different materials for constructing TEP scaffolds; ii) mechanical properties and surface topography in TEP; iii) cell‐based strategies for TEP construction; and iv) TEP combined with growth factors. In addition, current challenges and future perspectives for development of TEP are discussed.

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Bio-based polyurethane for tissue engineering applications: How hydroxyapatite nanoparticles influence the structure, thermal and biological behavior of polyurethane composites

Cited by 39 publications

References 30 publications

Fabrication of Scaffolds for Bone-Tissue Regeneration

Fabrication of Scaffolds for Bone-Tissue Regeneration

Synthesis, structure and properties of poly(ester-urethane)s obtained using bio-based and petrochemical 1,3-propanediol and 1,4-butanediol

Periosteal Tissue Engineering: Current Developments and Perspectives

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