Periosteal Tissue Engineering: Current Developments and Perspectives

Lou, Yiting; Wang, Huiming; Ye, Guanchen; Li, Yongzheng; Liu, Chao; Yu, Mengfei; Ying, Binbin

doi:10.1002/adhm.202100215

Cited by 34 publications

(33 citation statements)

References 192 publications

(226 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The periosteum mainly plays an osteogenic role through periosteum stem cells (Debnath et al, 2018), whereas the extracellular matrix of the periosteum plays a synergistic role in osteogenesis (Sun et al, 2019). In addition, the blood supply to the periosteum is rich (Lou et al, 2021), which is of great significance for the formation of new bone. Bone powder is widely used to guide bone regeneration.…”

Section: Traditional Method: Periosteum and Bone Powdermentioning

confidence: 99%

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

Xu-tao

Wan

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Chronic periapical periodontitis (CAP) is a typical oral disease in which periodontal inflammation caused by an odontogenic infection eventually leads to bone loss. Uncontrolled infections often lead to extensive bone loss around the root tip, which ultimately leads to tooth loss. The main clinical issue in the treatment of periapical periodontitis is the repair of jawbone defects, and infection control is the first priority. However, the oral cavity is an open environment, and the distribution of microorganisms through the mouth in jawbone defects is inevitable. The subversion of host cell metabolism by oral microorganisms initiates disease. The presence of microorganisms stimulates a series of immune responses, which in turn stimulates bone healing. Given the above background, we intended to examine the paradoxes and connections between microorganisms and jaw defect repair in anticipation of new ideas for jaw defect repair. To this end, we reviewed the microbial factors, human signaling pathways, immune cells, and cytokines involved in the development of CAP, as well as concentrated growth factor (CGF) and stem cells in bone defect repair, with the aim of understanding the impact of microbial factors on host cell metabolism to inform the etiology and clinical management of CAP.

show abstract

Section: Traditional Method: Periosteum and Bone Powdermentioning

confidence: 99%

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

Xu-tao

Wan

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…The most widely studied natural polymer materials are polysaccharide polymers and polypeptide polymers, such as chitosan and collagen membranes which are widely used as bone-healing materials [15][16][17]. However, natural biopolymers lack mechanical properties and do not meet the requirements for temporary mechanical substitution of periosteum tissue.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Silk Fibroin/Sericin Composite Film: Preparation, Mechanical Properties and Mineralization Activity

Tian

Zhang

et al. 2022

Polymers

View full text Add to dashboard Cite

The periosteum plays an important role in bone formation and reconstruction. One of the reasons for the high failure rate of bone transplantation is the absence of the periosteum. Silk fibroin (SF) and silk sericin (SS) have excellent biocompatibility and physicochemical properties, which have amazing application prospects in bone tissue engineering, but lacked mechanical properties. We developed a series of SF/SS composite films with improved mechanical properties using boiling water degumming, which caused little damage to SF molecular chains to retain larger molecules. The Fourier transform infrared spectroscopy and X-ray diffraction results showed that there were more β-sheets in SF/SS films than in Na2CO3 degummed SF film, resulting in significantly improved breaking strength and toughness of the composite films, which were increased by approximately 1.3 and 1.7 times, respectively. The mineralization results showed that the hydroxyapatite (HAp) deposition rate on SF/SS composite films was faster than that on SF film. The SF/SS composite films effectively regulated the nucleation, growth and aggregation of HAp-like minerals, and the presence of SS accelerated the early mineralization of SF-based materials. These composite films may be promising biomaterials in the repair and regeneration of periosteum.

show abstract

“…Via 3D printing, the graft can be formed to match defect geometry and patient anatomy using patient imaging data. Guided by the importance of the periosteum in native bone, a connective tissue layer surrounding native bone as a vascular source for native bone repair ( Bahney et al, 2019 ; Lou et al, 2021 ), a simple tissue shell, derived from MSCs and isolated, human adipose microvessels (haMVs), is formed around the printed DBM structure and serves to stabilize and pre-vascularize the graft prior to implantation. HaMVs are fragments of intact adipose microvasculature that retain full tissue vascularization potential and can be harvested from the patient ( Shepherd et al, 2004 ), alleviating issues of tissue incompatibility.…”

Section: Introductionmentioning

confidence: 99%

A Biofabrication Strategy for a Custom-Shaped, Non-Synthetic Bone Graft Precursor with a Prevascularized Tissue Shell

Moss¹,

Ortiz-Hernández

Levin

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Critical-sized defects of irregular bones requiring bone grafting, such as in craniofacial reconstruction, are particularly challenging to repair. With bone-grafting procedures growing in number annually, there is a reciprocal growing interest in bone graft substitutes to meet the demand. Autogenous osteo(myo)cutaneous grafts harvested from a secondary surgical site are the gold standard for reconstruction but are associated with donor-site morbidity and are in limited supply. We developed a bone graft strategy for irregular bone-involved reconstruction that is customizable to defect geometry and patient anatomy, is free of synthetic materials, is cellularized, and has an outer pre-vascularized tissue layer to enhance engraftment and promote osteogenesis. The graft, comprised of bioprinted human-derived demineralized bone matrix blended with native matrix proteins containing human mesenchymal stromal cells and encased in a simple tissue shell containing isolated, human adipose microvessels, ossifies when implanted in rats. Ossification follows robust vascularization within and around the graft, including the formation of a vascular leash, and develops mechanical strength. These results demonstrate an early feasibility animal study of a biofabrication strategy to manufacture a 3D printed patient-matched, osteoconductive, tissue-banked, bone graft without synthetic materials for use in craniofacial reconstruction. The bone fabrication workflow is designed to be performed within the hospital near the Point of Care.

show abstract

Periosteal Tissue Engineering: Current Developments and Perspectives

Cited by 34 publications

References 192 publications

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

Enhanced Silk Fibroin/Sericin Composite Film: Preparation, Mechanical Properties and Mineralization Activity

A Biofabrication Strategy for a Custom-Shaped, Non-Synthetic Bone Graft Precursor with a Prevascularized Tissue Shell

Contact Info

Product

Resources

About