Binuclear Cu(II) and Co(II) Complexes of Tridentate Heterocyclic Shiff Base Derived from Salicylaldehyde with 4-Aminoantipyrine

Abstract

New binuclear Co(II) and Co(II) complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points. It has been found that the Schiff bases with Cu(II) or Co(II) ion forming binuclear complexes on (1 : 1) “metal : ligand” stoichiometry. The molar conductance measurements of the complexes in DMSO correspond to be nonelectrolytic nature for all prepared complexes. Distorted octahedral environment is suggested for metal complexes. A theoretical treatment of the formation of complexes in the gas phase was studied, and this was done by using the HyperChem-6 program for the molecular mechanics and semi-empirical calculations. The free ligand and its complexes have been tested for their antibacterial activities against two types of human pathogenic bacteria: the first type (Staphylococcus aureus) is Gram positive and the second type (Escherichia coli) is Gram negative (by using agar well diffusion method). Finally, it was found that compounds show different activity of inhibition on growth of the bacteria.

Transition Metal Complexes of 4-Aminoantipyrine Derivatives and Their Antimicrobial Applications

“…Al-Obaidi et al [ 28 ] developed two Schiff base derivatives of 4-aminoantipyrine treated them with hydrated cobalt(II) chloride and copper(II) chloride to produce binuclear metal complexes 70 – 73 . Both the metal centers in the complex were found to acquire octahedral geometry with one ligand coordinating in tridentate ONO fashion and the other ligand in monodentate ( 70 – 71 ) or bidentate ( 72 – 73 ) fashion.…”

Synthesis, Spectral Characterization, Computational Revisions, Toxicology Studies In Addition To Biotic Studies of O-Phenylenediamine Based Schiff Base and Its Transition Metal Complexes

“…The Schiff base ligand had extra anti-bacterial activity than former ligands used and this activity was owed to the being there of electron releasing groups such as -Ph, -OH, and -N=CH- 39 . The anti-bacterial study effects were presented in the Figure 7.…”

Spectroscopic and electrochemical investigations and antibacterial activity of binuclear Pd(II) and Pt(IV) complexes of newly synthesized tridentate heterocyclic compounds

“…Heterocyclic phenazone and their derivatives (4-aminoantipyrine) are known to act as bidentate or tridentate ligands when coordinated to metal ion and can form mononuclear and binuclear complexes [11][12][13][14].…”