Binuclear copper complexes: Synthesis, X-ray structure and interaction study with nucleotide/protein by in vitro biochemical and electrochemical analysis

Nickel(ii) and copper(ii) complexes constructed with N2S2 hybrid benzamidine–thiosemicarbazone ligand: synthesis, X-ray crystal structure, DFT, kinetico-catalytic and in vitro biological applications

“…The extent of quenching of the uorescence of the EB bound to DNA would reect the extent of DNA binding of the second molecule. 37 Keeping the abovementioned fact in mind, as the concentration of H 2 L and its complexes, 1 and 2, increased, the emission band at 604 nm ( Fig. 6) for EB exhibited hypochromism up to 26.97%, 47.95% and 31.41%, respectively, with a slight red/blue shi from the initial uorescence.…”

Heptacopper(II) and dicopper(II)-adenine complexes: synthesis, structural characterization, and magnetic properties

“…Dinuclear copper compounds are by far the most abundant [14][15][16][17][18], but polynuclear copper structures, in which the number of metal ions, (n), ranges from 3 to 8, are also common [19][20][21][22]. The number of studies for heptanuclear copper complexes has significantly increased in the last fifteen years [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38].…”

Synthesis and characterization of ruthenium(II) hydrazone complexes as anticancer chemotherapeutic agents: in vitro DNA/BSA protein binding and cytotoxicity assay

“…Interaction between small molecules and DNA can often manipulate biodistribution, DNA binding rate and mode, as well as recognition by DNA-repair mechanisms, causing damage to cancer cells, blocking the division of cancer cells, and even death of cancer cells [7]. Thus, it was thought worthwhile to study the interaction of metal-based drugs with DNA for a better understanding of their pharmacological properties to design new therapeutic agents [8]. Serum albumin has long been the center of attention of the pharmaceutical industry due to its ability to bind with various drug molecules and alter the overall distribution, metabolism, and efficacy of many drugs based on their affinity to serum albumin [9,10].…”