Binge drinking during the adolescence period causes oxidative damage-induced cardiometabolic disorders: A possible ameliorative approach with selenium supplementation

Ojeda, María Luisa; Nogales, Fátima; Gallego-López, María del Carmen; Carreras, Olimpia

doi:10.1016/j.lfs.2022.120618

Cited by 14 publications

(16 citation statements)

References 117 publications

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“…Our findings were supported by the work of Chen et al [ 14 ]. The keap1-Nrf2 signaling pathway is an effective way for the body to relieve stress by encoding antioxidant enzymes and phase II detoxification enzymes to resist endogenous or exogenous oxidative stress [ 55 , 56 , 57 , 58 ]. Here, an obvious increase in Nrf2 , keap1 , and HO1 gene expression was noted in the MMT group, which suggested that the keap1-Nrf2 pathway is involved in an antioxidized capacity exerted by MMT.…”

Section: Discussionmentioning

confidence: 99%

Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity

et al. 2022

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This study aims to explore the effects of modified montmorillonite (MMT, copper loading) on the growth performance, gut microbiota, intestinal barrier, antioxidative capacity and immune function of broilers. Yellow-feathered broilers were randomly divided into control (CTR), modified montmorillonite (MMT), and antibiotic (ANTI) groups. Results revealed that MMT supplementation increased the BW and ADG and decreased the F/R during the 63-day experiment period. 16S rRNA sequencing showed that MMT modulated the cecal microbiota composition of broilers by increasing the relative abundance of two phyla (Firmicutes and Bacteroidetes) and two genera (Bacteroides and Faecalibacterium) and decreasing the abundance of genus Olsenella. MMT also improved the intestinal epithelial barrier indicated by the up-regulated mRNA expression of claudin-1, occludin, and ZO-1 and the increased length of microvilli in jejunum and the decreased levels of DAO and D-LA in serum. In addition, MMT enhanced the immune function indicated by the increased levels of immunoglobulins, the decreased levels of MPO and NO, the down-regulated mRNA expression of IL-1β, IL-6, and TNF-α, and the up-regulated mRNA expression of IL-4 and IL-10. Moreover, MMT down-regulated the expression of jejunal TLRs/MAPK/NF-κB signaling pathway-related genes (TLR2, TLR4, Myd88, TRAF6, NF-κB, and iNOS) and related proteins (TRAF6, p38, ERK, NF-κB, and iNOS). In addition, MMT increased the antioxidant enzyme activities and the expression of Nrf2/HO-1 signaling pathway-related genes and thereby decreased the apoptosis-related genes expression. Spearman’s correlation analysis revealed that Bacteroides, Faecalibacterium, and Olsenella were related to the inflammatory index (MPO and NO), oxidative stress (T-AOC, T-SOD, and CAT) and intestinal integrity (D-LA and DAO). Taken together, MMT supplementation improved the growth performance of broilers by modulating intestinal microbiota, enhancing the intestinal barrier function, and improving inflammatory response, which might be mediated by inhibiting the TLRs/MAPK/NF-κB signaling pathway, and antioxidative capacity mediated by the Nrf2/HO-1 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity

et al. 2022

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“…The experimental protocol was conducted over a 3 week period, beginning when the rats reached postnatal day 28 and ending at 47 days of age. This period corresponds to the adolescence in Wistar rats (Ojeda et al., 2022). The animals were kept under a 12:12 h light/dark photocycle (lights on 09.00 h) at 22–23°C.…”

Section: Methodsmentioning

confidence: 99%

“…Binge drinking (BD) is defined by the National Institute on Alcohol Abuse and Alcoholism (2020) as an acute ethanol (EtOH) consumption model, which brings blood alcohol concentration (BAC) to 0.08% or higher within 2 h. Nowadays, BD is a serious health issue among young people (Ojeda et al., 2022; Pompili & Laghi, 2019). This consumption is deeply related to oxidative damage as a result of the high BAC reached because, in tissues, EtOH saturates the activity of its main metaboliser enzyme, alcohol dehydrogenase (ADH), and drastically increases the activity of cytochrome P450 2E1 (CYP2E1) (Teschke, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Adolescence is a complex period, which involves many different hormonal pathways that orchestrate physical and biological changes, encompassing increased growth and metabolic rate, alterations in fat and muscle, and breast and genital development (Khan, 2019; Vijayakumar et al., 2018). In this context, BD consumption during adolescence has recently been associated with hepatic damage (Taylor & Miloh, 2019), increased heart rate (Ojeda et al., 2021; Ramírez‐Piña et al., 2021), reduced microvasculature function (Bian et al., 2018), kidney ionic imbalance (Sobrino et al., 2019) and even insulin disturbances (Steiner & Lang, 2017), which are situations that predispose adolescents to future adult cardiometabolic problems (Ojeda et al., 2022). Furthermore, the adolescent heart is substantially more sensitive to these effects than the adult one (Ai et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

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Adipose tissue homeostasis orchestrates the oxidative, energetic, metabolic and endocrine disruption induced by binge drinking in adolescent rats

Romero‐Herrera,

Nogales,

Gallego‐López

et al. 2023

The Journal of Physiology

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Binge drinking (BD) is the most common alcohol consumption model for adolescents, and has recently been related to the generation of high oxidation and insulin resistance (IR). White adipose tissue (WAT) is a target organ for insulin action that regulates whole‐body metabolism by secreting adipokines. The present study aimed to analyse the oxidative, inflammatory, energetic and endocrine profile in the WAT of BD‐exposed adolescent rats, to obtain an integrative view of insulin secretion and WAT in IR progression. Two groups of male adolescent rats were used: control (n = 8) and BD (n = 8). An intermittent i.p. BD model (20% v/v) was used during 3 consecutive weeks. BD exposure led to a pancreatic oxidative imbalance, which was joint to high insulin secretion by augmenting deacetylase sirtuin‐1 (SIRT‐1) pancreatic expression and serum adipsin levels. However, BD rats had hyperglycaemia and high homeostasis model assessment of insulin resistance value (HOMA‐IR). BD exposure in WAT increased lipid oxidation, as well as decreased insulin receptor substrate 1 (IRS‐1) and AKT expression, sterol regulatory element‐binding protein 1 (SREBP1), forkhead box O3A (FOXO3a) and peroxisome proliferator‐activated receptor γ (PPARγ), and adipocyte size. BD also affected the expression of proteins related to energy balance, such as SIRT‐1 and AMP activated protein kinase (AMPK), affecting the adipokine secretion profile (increasing resistin/adiponectin ratio). BD altered the entire serum lipid profile, increasing the concentration of free fatty acids. In conclusion, BD led to an oxidative imbalance and IR process in WAT, which modified the energy balance in this tissue, decreasing the WAT lipogenic/lipolytic ratio, affecting adipokine secretion and the systemic lipid profile, and contributing to the progression of IR. Therefore, WAT is key in the generation of metabolic and endocrine disruption after BD exposure during adolescence in rats. imageKey points Adolescent rat binge drinking (BD) exposure leads to hepatic and systemic oxidative stress (OS) via reactive oxygen species generation, causing hepatic insulin resistance (IR) and altered energy metabolism. In the present study, BD exposure in adolescent rats induces OS in the pancreas, with increased insulin secretion despite hyperglycaemia, indicating a role for IR in white adipose tissue (WAT) homeostasis. In WAT, BD produces IR and an oxidative and energetic imbalance, triggering an intense lipolysis where the serum lipid profile is altered and free fatty acids are increased, consistent with liver lipid accumulation and steatosis. BD exposure heightens inflammation in WAT, elevating pro‐inflammatory and reducing anti‐inflammatory adipokines, favouring cardiovascular damage. This research provides a comprehensive view of how adolescent BD in rats impacts liver, WAT and pancreas homeostasis, posing a risk for future cardiometabolic complications in adulthood.

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“…62,63 In addition, the OS generated in the mitochondria of kidney cells, which highly depends on NOX4 activity, triggers apoptosis, inflammation and cell dysfunctions, mainly in the nephron tubular cells. 4 Lately, the high systemic ROS production that appears after BD exposure is also proposed as the main mechanism which contributes to generate osmotic and ionic disturbance. 6 Acute EtOH stimulates the SNS, the HHA and the RAAS, promoting higher concentrations of anti-diuretic and anti-natriuretic with vasoconstrictor properties, 14 such as those increased after BD exposure adolescence.…”

Section: Hydric-electrolyte Balancementioning

confidence: 99%

Folic acid antioxidant supplementation to binge drinking adolescent rats improves hydric‐saline balance and blood pressure, but fails to increase renal NO availability and glomerular filtration rate

Gallego‐López,

Ojeda,

Romero‐Herrera

et al. 2023

The FASEB Journal

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Binge drinking (BD) is an especially pro‐oxidant pattern of alcohol consumption, particularly widespread in the adolescent population. In the kidneys, it affects the glomerular filtration rate (GFR), leading to high blood pressure. BD exposure also disrupts folic acid (FA) homeostasis and its antioxidant properties. The aim of this study is to test a FA supplementation as an effective therapy against the oxidative, nitrosative, and apoptotic damage as well as the renal function alteration occurred after BD in adolescence. Four groups of adolescent rats were used: control, BD (exposed to intraperitoneal alcohol), control FA‐supplemented group and BD FA‐supplemented group. Dietary FA content in control groups was 2 ppm, and 8 ppm in supplemented groups. BD provoked an oxidative imbalance in the kidneys by dysregulating antioxidant enzymes and increasing the enzyme NADPH oxidase 4 (NOX4), which led to an increase in caspase‐9. BD also altered the renal nitrosative status affecting the expression of the three nitric oxide (NO) synthase (NOS) isoforms, leading to a decrease in NO levels. Functionally, BD produced a hydric‐electrolytic imbalance, a low GFR and an increase in blood pressure. FA supplementation to BD adolescent rats improved the oxidative, nitrosative, and apoptotic balance, recovering the hydric‐electrolytic equilibrium and blood pressure. However, neither NO levels nor GFR were recovered, showing in this study for the first time that NO availability in the kidneys plays a crucial role in GFR regulation that the antioxidant effects of FA cannot repair.

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Binge drinking during the adolescence period causes oxidative damage-induced cardiometabolic disorders: A possible ameliorative approach with selenium supplementation

Cited by 14 publications

References 117 publications

Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity

Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity

Adipose tissue homeostasis orchestrates the oxidative, energetic, metabolic and endocrine disruption induced by binge drinking in adolescent rats

Folic acid antioxidant supplementation to binge drinking adolescent rats improves hydric‐saline balance and blood pressure, but fails to increase renal NO availability and glomerular filtration rate

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