Binge drinking: Burden of liver disease and beyond

Abstract

binge drinking has generalized. It is considered to be a socio-sanitary problem with few known consequences in terms of individual and third-party social impacts (in the form of violence or traffic accidents) and its organic impact (affects the liver and other organs and systems, such as the nervous and cardiovascular systems) and represents an important financial burden due to its increasing economic impact. This review provides a global approach to binge drinking and emphasizes its epidemiological character, the effect of this type of consumption and the possible management of a problem with an increasing tendency in our society. Core tip: Binge drinking is an alcohol consumption conduct that is primarily performed during the weekend by 24% of teenagers and young adults. Although the consequences of this habit are not well known, they have a social and organic impact on individuals. Binge drinking is considered to be a public health issue that should be addressed with primary prevention programs and a comprehensive intervention of the problem. Author contributions: Llerena S, Arias-Loste MT, Puente A, Cabezas J, Crespo J and Fábrega E contributed equally to this work; Llerena S and Fábrega E wrote the paper. Conflict-of-interest statement:The authors of the present manuscript declare no conflict of interests. AbstractThe consumption of alcoholic beverages is harmful to human health. In recent years, consumption patterns of alcoholic beverages have changed in our society, and

Binge drinking and the risk of liver events: A population‐based cohort study

“…The phenomenon of drinking too much too fast, termed binge drinking, is growing in Western countries, especially in the UK and northern Europe . Although there is no standard definition of binge drinking, the most widely used definition is the consumption of five or more drinks on a single occasion or day, or sometimes modified to ≥5 drinks for men and ≥4 drinks for women in about 2 hours . Around 20% of adults in Europe and 17% in USA report binge drinking up to once a week …”

“…Animal studies suggest that binge drinking alone induces liver damage and increases liver injury in chronically alcohol‐exposed livers, but human data are limited. Several authors have noted the need for further study to define the impact of binge drinking on the risk of liver disease, and recent guidelines prioritise this specific research topic…”

Overdrinking, swallowing inhibition, and regional brain responses prior to swallowing

“…2, 5, 6, 12, and 18-20), they have received relatively little attention in humans despite their relevance to dysfunctional drinking behavior. This behavior includes the binge drinking associated with drinking alcohol (21), which is particularly prevalent among young adults (22), and the polydipsia linked to schizophrenia (23), which is associated with a higher mortality rate in the clinical population (24).…”

Using Zebrafish to Model Liver Diseases-Where Do We Stand?

“…In recent years, binge drinking is becoming an alarming global health problem [55]. Binge alcohol exposure causes liver inflammation, steatosis, hepatocyte death, and promotes activation of hepatic stellate cells and fibrogenesis [56].…”