Binge drinking and the risk of liver events: A population‐based cohort study

Åberg, Fredrik; Helenius‐Hietala, Jaana; Puukka, Pauli; Jula, Antti

doi:10.1111/liv.13408

Cited by 96 publications

(96 citation statements)

References 31 publications

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“…15 In the present study, we found binge drinking as a risk factor for both alcohol-related and non-alcohol-related liver diseases even though total alcohol intake was a risk factor only for alcohol-related diagnosis among men. This has been reported previously.…”

Section: Risk Factors For Advanced Liver Diseasesupporting

confidence: 42%

Genetic and lifestyle risk factors for advanced liver disease among men and women

Sahlman

Nissinen

Puukka

et al. 2019

J of Gastro and Hepatol

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Background and Aim Liver disease is traditionally categorized as alcoholic and non‐alcoholic. We studied various risk factors predictive of advanced non‐viral liver disease in general population and analyzed the interaction between these factors and alcohol consumption. Methods Persons without underlying liver disease who participated in the Health2000 or FINRISK studies 1992–2012 comprised a cohort of 41 260 individuals. Pattern of alcohol consumption and metabolic, lifestyle‐related, and anthropometric parameters were analyzed with Cox regression analysis using severe liver disease hospitalization, cancer, or death as end‐point. Viral liver diseases were excluded. Results A total of 355 liver events occurred during the mean 12.4‐year follow‐up (511 789 person‐years). In the multivariate model, age (hazard ratio [HR] 1.03, P = 0.0083 for men; HR 1.04, P = 0.0198 for women), waist‐to‐hip ratio (WHR) (HR 1.52, P = 0.0006 for men; HR 1.58, P = 0.0167 for women), patatin‐like phospholipase‐containing domain 3 mutations (HR 1.9, P = 0.024 for men; HR 2.7, P = 0.0109 for women), and weekly binge drinking (HR 2.4, P = 0.0024 for men; HR 7.4, P < 0.0001 for women) predicted development of severe liver disease. Among men, diabetes (HR 2.7, P = 0.0002), average alcohol consumption (HR for 10 g/day 1.1, P = 0.0022), non‐married status (HR 1.9, P = 0.0397 for single; HR 2.4, P = 0.0002 for widowed/separated), and serum high‐density lipoprotein (HR 2.2, P = 0.0022) and non‐high‐density lipoprotein cholesterol (HR 1.2, P = 0.0237) were additional risk factors. Alcohol intake increased the risk especially among persons with high WHR (P for interaction 0.009). Conclusions Age, patatin‐like phospholipase‐containing domain 3 haplotype, and WHR increase the risk for development of severe liver disease. We found strong synergism between alcohol and central obesity. Binge drinking is an additional risk factor.

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Section: Risk Factors For Advanced Liver Diseasesupporting

confidence: 42%

Genetic and lifestyle risk factors for advanced liver disease among men and women

Sahlman

Nissinen

Puukka

et al. 2019

J of Gastro and Hepatol

Self Cite

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“…A meta‐analysis of studies of alcohol consumption and cirrhosis risk confirmed increased risk for women . There is evidence that binge drinking increases the risk of ALD . Coffee consumption protects against cirrhosis of many causes, including ALD as well as AH …”

Section: Pathophysiology and Risk Factors For Alcohol‐associated Livementioning

confidence: 96%

Diagnosis and Treatment of Alcohol‐Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases

et al. 2020

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“…ALD and NAFLD are currently distinguished from each other by an arbitrary threshold of average alcohol intake of 30 g/day for men and 20 g/day for women . However, even lower amounts of alcohol intake have been linked to increased liver mortality, and subjects with metabolic risk factors may be particularly sensitive to alcohol‐induced liver injury . These findings are controversial, however, because mild to moderate alcohol use has also been associated with an improved lipid profile, anti‐inflammatory effects, improved insulin sensitivity, and decreased risk of having NAFLD …”

mentioning

confidence: 99%

Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population

Åberg

Helenius‐Hietala

Puukka³

et al. 2018

Hepatology

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186

177

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Binge drinking and the risk of liver events: A population‐based cohort study

Abstract: Binge drinking is associated with an increased risk for liver disease independently of average alcohol intake and confounders. The rising prevalence of binge drinking and the metabolic syndrome is particularly concerning.

Cited by 96 publications

References 31 publications

Genetic and lifestyle risk factors for advanced liver disease among men and women

Genetic and lifestyle risk factors for advanced liver disease among men and women

Diagnosis and Treatment of Alcohol‐Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases

Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population

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