Binding studies of ( N -(methylpyridin-2-yl)-amidino- O -methylurea)copper(II) complexes to four nitrogenous bases and 5′-GMP

Effects of N,N-heterocyclic ligands on the in vitro cytotoxicity and DNA interactions of copper(ii) chloride complexes from amidino-O-methylurea ligands

“…Previous reports revealed the interesting antibacterial activities of some copper(II) complexes of amidino-O-alkylurea derivatives against Bacillus, 75 E. coli, 12,76,77 K. Pneumonia and P. mirabilis, 76 Salmonella and Campylobacter. 10,12,77 Herein, our compounds containing amidino-O-methylurea derivatives and N,N-heterocycles were further tested to determine their in vitro antibacterial properties against E. coli, Salmonella and Campylobacter by the disc diffusion method. Their antibacterial activities were evaluated by their minimum inhibitory concentrations (MICs) (Table 7).…”

The effect of gallic acid on the copper(ii) complex ofN-(methylpyridin-2-yl)-amidino-O-methylurea: crystal structure, DNA interactions,in vitrocytotoxicity and antibacterial activity

“…This indicates that the unpaired electron of copper( ii ) is located in d x 2 −y 2 , and supports the proposed geometries of either a square pyramid or octahedron 55,56 (Table 1). The g ‖ values of [Cu(L 3m )Cl 2 ], 57 [Cu(asp)(phen)] 58 and [Cu(bpnp)(CH 3 COO)]·MeOH·C 8 H 10 59 exhibit the same g ‖ values as 1-HGA . On the other hand, the square planar [Cu(GA) 2 ] 60 complex gives a lower g ‖ value than 1-HGA , while the octahedral [Cu(4-FH)(phen)(ClO 4 ) 2 ], 61 [Cu(BH) 2 (SO 4 )]·2H 2 O 62 and [Cu(4-NH) 2 Cl 2 ] 63 complexes exhibit greater g ‖ values than our complex.…”

“…This indicates that the unpaired electron of copper(II) is located in d x 2 Ày 2, and supports the proposed geometries of either a square pyramid or octahedron 55,56 (Table 1). The g 8 values of [Cu(L 3m )Cl 2 ], 57 [Cu(asp)(phen)] 58 S2 and S3 (ESI †). Crystallographic data have shown the chemical formula of [CuL 3m (GA)]ClÁ3H 2 O, which crystallized in the monoclinic system with the P2 1 /n space group.…”