The effect of gallic acid on the copper(ii) complex ofN-(methylpyridin-2-yl)-amidino-O-methylurea: crystal structure, DNA interactions,in vitrocytotoxicity and antibacterial activity

Abstract

A new copper(ii) complex containing guanidine derivatives and gallic acid (1-HGA) interacted with CT-DNA via non-intercalation mode. 1-HGA was most active against MCF-7 cancer cells and had greater antibacterial activity than the starting compound.

Synthesis of an Aryl-Semicarbazone-Based Cu(II) Complex for DNA and BSA Interaction and Anti-Cancer Activity against Human Cervix Uteri Carcinoma

“…A considerable number of research articles proved that copper(II)-based complexes are also eligible to act as promising anti-cancer agents with comparatively low toxicity and side effects [7,8]. It is essential to choose suitable ligands because the biological activity of these ligands contributes significantly to the overall properties of biologically active complexes [9,10].…”

“…For instance, semicarbazone is an important pharmacophore in the search for new drugs [9,11]. The transition metal complexes with semicarbazone exhibit significant biological activity as the ligand, semicarbazone, itself has huge potential to act as a biologically 2 of 15 active reagent [12].…”