Binding specificity of α-bilirubin-imprinted poly(methacrylic acid-co-ethylene glycol dimethylacrylate) toward α-bilirubin

Syu, Mei-Jywan; Deng, Jing Hong; Nian, You Ming; Chiu, Tz Cheng; Wu, An Hua

doi:10.1016/j.biomaterials.2004.11.024

Cited by 29 publications

(12 citation statements)

References 31 publications

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“…The demonstration of template (or template analog)‐selective recognition by an MIP remains a cornerstone in the development of all new MIP systems. Various strategies have been employed to characterize ligand‐polymer binding events,…”

Section: Fundamental Aspectsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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SummaryHerein we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004 to 2011. In total, 3779 references to the original papers, reviews, edited volumes and monographs from this period are included, along with recently identified uncited materials from prior to 2004 which were omitted in the first instalment of this series covering the years 1930 to 2003. 1 In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by sections describing fundamental aspects of molecular imprinting including the development of novel polymer formats. Thereafter, literature describing efforts to apply these polymeric materials to a range of application areas is presented. Current trends and areas of rapid development are discussed.2

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Section: Fundamental Aspectsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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“…We employed a quartz crystal microbalance with dissipation (QCM-D, E4, Q-Sense, Goteborg, Sweden) to characterize the molecular self-assembly and bilirubin removal process. The bilirubin solution (0.2 mg/mL) 31 was prepared by dissolving 0.01 g of bilirubin and 0.01 mg of EDTA in 0.5 mL of 0.1 M NaOH solution and diluted with phosphate buffered saline (PBS, pH 7.4, 1×) to 50 mL. The EDTA was used to maintain the stability of the solution.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, there have been several kinds of adsorbents with β-CD for bilirubin removal, such as β-CDchitosan, 29 β-CD-PEI (polyethylenimine), 30 and β-CD-co-EGDMA (ethylene glycol dimethyl acrylate). 31 In addition to interacting with bilirubin, β-CD exhibits another classical host−guest interaction with adamantane (Ad). 32 In the last few decades, this interaction has been applied in several fields, including hydrogel cross-linking, 33 drug loading, 34 biological detection, 35 and water purification.…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Self-Assembled β-Cyclodextrin-Modified Surface for Blood Purification

Liu

Zhong

Chen

et al. 2017

ACS Biomater. Sci. Eng.

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For patients with liver failure, bilirubin (BR) is one of the endogenous toxins in their blood. Although blood purification can remove the bilirubin from the body in clinics, the detoxification system needs to be improved, and the cost needs to be decreased. In the present study, we developed a recyclable model surface that can strongly remove bilirubin. We first prepared adamantane (Ad) on a model gold surface by self-assembly. Then, we integrated the β-cyclodextrin dimer (CDD) onto the surface with host−guest interactions between one of the CD cavities in the CDD and Ad. We characterized the surface with XPS, static contact angle measurements, and AFM. In addition, we employed QCM-D to characterize the preparation process as well as the detoxification of the surface. We demonstrated that this modified surface could strongly adsorb bilirubin through host−guest interactions between the CD cavities in the CDD and bilirubin and that the detoxification was improved 1.7 times (compared to the surface only with Ad). Interestingly, after characterization with QCM-D, this surface could be recycled due to the thermoresponsive property of the host−guest interaction between the CDD and Ad. After adsorbing the toxin and increasing the temperature to 45 °C, the CDD with bilirubin could be removed from the surface. Then, the refreshed surface with CDD could be prepared again at room temperature. This cycle could be repeated at least 3 times. Additionally, during each cycle, the modified surface exhibited good detoxification to bilirubin. This modified surface also showed strong resistance to plasma proteins, decreasing the adsorption of human serum albumin (HSA) and fibrinogen (Fg). An in vitro platelet adhesion assay showed that the adhesion of the platelets on the modified surface decreased and that the platelets were in an inactivated state. The hemolysis assay showed that this surface exhibited no hemolysis activity in the samples to red blood cells (RBCs). The CCK-8 assay showed that this surface had negligible cytotoxicity to L929 cells. This work has taken advantage of the host−guest self-assembly between β-CD and BR/Ad for special recognizing adsorption, as well as the thermoresponse of β-CD-Ad inclusion for recyclable application, and these results demonstrate that this technology has great potential for removing bilirubin and decreasing clinic costs.

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“…The flexibility of MIP formed from non-covalent interactions is preferred because the binding site is more heterogeneous so that the resulting MIP is more varied. The non-covalent interaction of binding is weaker so that it is easily decided compared to the covalent interaction that must be decided with an acid solvent [5,6].…”

Section: Introductionmentioning

confidence: 99%

Adsorption Capacity and Selectivity of Molecularly Imprinted Polymers towards β-Sitosterol

et al. 2019

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Molecularly imprinted polymers (MIP) as an adsorbent has been synthesized using β-sitosterol as molecule template on free radical polymerization reaction. The capacity and selectivity of the adsorption from MIP to β-sitosterol was studied in this study. The β-sitosterol concentration in the adsorption-desorption test and the MIP selectivity test were analyzed by UV-visible and HPLC. The MIP obtained from the synthesis results in a high adsorption capacity. Based on the Freundlich adsorption isothermal equation, the adsorption capacity (k) was found to be 1.24 mg/g. The MIP can adsorb 100 % β-sitosterol while cholesterol was only 3 %. The MIP is most selective to β-sitosterol, therefore, has high potential to apply as adsorbent at solid phase extraction method to isolate β-sitosterol from sample extract.

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Binding specificity of α-bilirubin-imprinted poly(methacrylic acid-co-ethylene glycol dimethylacrylate) toward α-bilirubin

Cited by 29 publications

References 31 publications

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Thermoresponsive Self-Assembled β-Cyclodextrin-Modified Surface for Blood Purification

Adsorption Capacity and Selectivity of Molecularly Imprinted Polymers towards β-Sitosterol

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