Binding properties to nicotinic acetylcholine receptors can explain differential toxicity of neonicotinoid insecticides in Chironomidae

Maloney, Erin M.; Taillebois, Emiliane; Gilles, Nicolas; Morrissey, Christy A.; Liber, Karsten; Servent, Denis; Thany, Steeve Hervé

doi:10.1016/j.aquatox.2020.105701

Cited by 20 publications

(21 citation statements)

References 69 publications

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“…4A). These refinements in effect levels indicate that CLO is comparably or more toxic than IMI, an observation reported by others ( 21 , 22 , 39 ) and consistent with the fact that CLO binds more readily than IMI with the site of toxic action in aquatic insects ( 46 ).…”

Section: Discussionsupporting

confidence: 87%

“…To test how trophodynamics of benthic communities were affected by exposure to unary and binary mixtures of neonicotinoids and controls, we tested simple networks of cause-effect relationships describing a trophic cascade and predator-prey relationships using a path-analytic approach (R package “piecewiseSEM”) ( 46 ). The presence of IMI or CLO individually and as a mixture was hypothesized to directly reduce the biomass of scrapers and to indirectly cause an increase in the biomass of ChlA due to reduced grazing pressure ( 47 ).…”

Section: Methodsmentioning

confidence: 99%

“…Compound concentrations were the predictor variables, and ChlA and the biomass of insects with the ecological feeding traits scraper, predator, and nonpredators (prey) were response variables. The Fisher’s C statistic was used to assess the general fit of each model, where P values of <0.05 were defined as indicating a good fit ( 46 ) for the trophic cascade models; because the predator-prey models are saturated, there are no degrees of freedom to test the general model fit. Models were not contrasted against one another.…”

Section: Methodsmentioning

confidence: 99%

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Ecological consequences of neonicotinoid mixtures in streams

et al. 2022

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Neonicotinoid mixtures are common in streams worldwide, but corresponding ecological responses are poorly understood. We combined experimental and observational studies to narrow this knowledge gap. The mesocosm experiment determined that concentrations of the neonicotinoids imidacloprid and clothianidin (range of exposures, 0 to 11.9 μg/liter) above the hazard concentration for 5% of species (0.017 and 0.010 μg/liter, respectively) caused a loss in taxa abundance and richness, disrupted adult emergence, and altered trophodynamics, while mixtures of the two neonicotinoids caused dose-dependent synergistic effects. In 85 Coastal California streams, neonicotinoids were commonly detected [59% of samples ( n = 340), 72% of streams], frequently occurred as mixtures (56% of streams), and potential toxicity was dominated by imidacloprid (maximum = 1.92 μg/liter) and clothianidin (maximum = 2.51 μg/liter). Ecological responses in the field were consistent with the synergistic effects observed in the mesocosm experiment, indicating that neonicotinoid mixtures pose greater than expected risks to stream health.

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Section: Discussionsupporting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Ecological consequences of neonicotinoid mixtures in streams

et al. 2022

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“…Pesticides could enter aquatic insects through contact or feeding [ 136 ]. The impact of pesticides reaching streams and potentially harming the aquatic juvenile stages has drawn extensive concerns when investigating the effects of insecticides on freshwater insects [ 137 , 138 ]. There are few studies on the effects of pesticide residues in insects on human health.…”

Section: Safety In Utilization Of Edible Aquatic Insectsmentioning

confidence: 99%

Edible Aquatic Insects: Diversities, Nutrition, and Safety

Zhao

Wang

Sun

et al. 2021

Foods

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Edible insects have great potential to be human food; among them, aquatic insects have unique characteristics and deserve special attention. Before consuming these insects, the nutrition and food safety should always be considered. In this review, we summarized the species diversity, nutrition composition, and food safety of edible aquatic insects, and also compared their distinguished characteristics with those of terrestrial insects. Generally, in contrast with the role of plant feeders that most terrestrial edible insect species play, most aquatic edible insects are carnivorous animals. Besides the differences in physiology and metabolism, there are differences in fat, fatty acid, limiting/flavor amino acid, and mineral element contents between terrestrial and aquatic insects. Furthermore, heavy metal, pesticide residue, and uric acid composition, concerning food safety, are also discussed. Combined with the nutritional characteristics of aquatic insects, it is not recommended to eat the wild resources on a large scale. For the aquatic insects with large consumption, it is better to realize the standardized cultivation before they can be safely eaten.

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“…The observation highlighted the significant difference amongst larvae that expressed high imidacloprid affinity and higher density of nAChRs in comparison to adults. Differences in neonicotinoid binding at receptor-level was speculated to be responsible for eco-toxicological differences between insect, life stages and compound-specific binding properties which can further aid to enhance the practices of risk assessment for neonicotinoids and other nAChR selective insecticides during registration, risk assessment and regulation of product to understand harmful effects linked with unintentional neonicotinoid exposure [68].…”

Section: Toxicity Of Neonicotinoids Towards Aquatic Invertebratesmentioning

confidence: 99%

Physiological Effects of Neonicotinoid Insecticides on Non-Target Aquatic Animals—An Updated Review

Malhotra

Chen

Huang

et al. 2021

IJMS

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In this paper, we review the effects of large-scale neonicotinoid contaminations in the aquatic environment on non-target aquatic invertebrate and vertebrate species. These aquatic species are the fauna widely exposed to environmental changes and chemical accumulation in bodies of water. Neonicotinoids are insecticides that target the nicotinic type acetylcholine receptors (nAChRs) in the central nervous systems (CNS) and are considered selective neurotoxins for insects. However, studies on their physiologic impacts and interactions with non-target species are limited. In researches dedicated to exploring physiologic and toxic outcomes of neonicotinoids, studies relating to the effects on vertebrate species represent a minority case compared to invertebrate species. For aquatic species, the known effects of neonicotinoids are described in the level of organismal, behavioral, genetic and physiologic toxicities. Toxicological studies were reported based on the environment of bodies of water, temperature, salinity and several other factors. There exists a knowledge gap on the relationship between toxicity outcomes to regulatory risk valuation. It has been a general observation among studies that neonicotinoid insecticides demonstrate significant toxicity to an extensive variety of invertebrates. Comprehensive analysis of data points to a generalization that field-realistic and laboratory exposures could result in different or non-comparable results in some cases. Aquatic invertebrates perform important roles in balancing a healthy ecosystem, thus rapid screening strategies are necessary to verify physiologic and toxicological impacts. So far, much of the studies describing field tests on non-target species are inadequate and in many cases, obsolete. Considering the current literature, this review addresses important information gaps relating to the impacts of neonicotinoids on the environment and spring forward policies, avoiding adverse biological and ecological effects on a range of non-target aquatic species which might further impair the whole of the aquatic ecological web.

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Binding properties to nicotinic acetylcholine receptors can explain differential toxicity of neonicotinoid insecticides in Chironomidae

Cited by 20 publications

References 69 publications

Ecological consequences of neonicotinoid mixtures in streams

Ecological consequences of neonicotinoid mixtures in streams

Edible Aquatic Insects: Diversities, Nutrition, and Safety

Physiological Effects of Neonicotinoid Insecticides on Non-Target Aquatic Animals—An Updated Review

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