Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors α and β: A Fluorescence Polarization Assay

Luft, S; Milki, Elias Aba; Glustrom, Eric; Ampiah-Bonney, Richmond J.; O’Hara, Patricia B.

doi:10.1016/j.bpj.2008.12.2282

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, aldrin, aroclor and CPF have shown to interact with ERβ among other intracellular targets (Luft et al, 2009). This receptor has been implicated in mediating effects of EDs; (Kuiper et al, 1998) in the case of PCBs, for example, they induce a significant reduction of ERβ in anteroventral periventricular nucleus of brain rats (Salama et al, 2003).…”

Section: Introductionmentioning

confidence: 98%

Phenotypic malignant changes and untargeted lipidomic analysis of long-term exposed prostate cancer cells to endocrine disruptors

Bedia

Dalmau

Jaumot

et al. 2015

Environmental Research

View full text Add to dashboard Cite

Endocrine disruptors (EDs) are a class of environmental toxic molecules able to interfere with the normal hormone metabolism. Numerous studies involve EDs exposure to initiation and development of cancers, including prostate cancer. In this work, three different EDs (aldrin, aroclor 1254 and chlorpyrifos (CPF)) were investigated as potential inducers of a malignant phenotype in DU145 prostate cancer cells after a chronic exposure. Epithelial to mesenchymal transition (EMT) induction, proliferation, migration, colony formation and release of metalloproteinase 2 (MMP-2) were analyzed in 50-day exposed cells to the selected EDs. As a result, aldrin and CPF exposure led to an EMT induction (loss of 16% and 14% of E-cadherin levels, respectively, compared to the unexposed cells). Aroclor and CPF presented an increased migration (134% and 126%, respectively), colony formation (204% and 144%, respectively) and MMP-2 release (137% in both cases) compared to the unexposed cells. An untargeted lipidomic analysis was performed to decipher the lipids involved in the observed transformations. As general results, aldrin exposure showed a global decrease in phospholipids and sphingolipids, and aroclor and CPF showed an increase of certain phospholipids, glycosphingolipids as well as a remarkable increase of some cardiolipin species. Furthermore, the three exposures resulted in an increase of some triglyceride species. In conclusion, some significant changes in lipids were identified and thus we postulate that some lipid compounds and lipid metabolic pathways could be involved in the acquisition of the malignant phenotype in exposed prostate cancer cells to the selected EDs.

show abstract

Section: Introductionmentioning

confidence: 98%

Phenotypic malignant changes and untargeted lipidomic analysis of long-term exposed prostate cancer cells to endocrine disruptors

Bedia

Dalmau

Jaumot

et al. 2015

Environmental Research

View full text Add to dashboard Cite

show abstract

“…Because they are carcinogens, pesticides also have the potential to damage human endocrine glands and disturb the body's hormonal balance. Pesticide use in agricultural areas cannot be modified but a prudent pesticide usage and management could aid in preventing major environmental issues [37,38]. Pakistan is one of the nations in the world that uses pesticides in significant amounts, and the pesticide sector is a major part of the agricultural commodities to control weeds and insects [39,40].…”

Section: Introductionmentioning

confidence: 99%

Pesticides, Heavy Metals and Plasticizers: Contamination and Risk Assessment of Drinking-Water Quality

Adil,

Ashraf,

Munir

et al. 2023

Sustainability

View full text Add to dashboard Cite

This study highlights the impact of formal agricultural practices and their adverse effect on the deterioration of underground water quality, with special emphasis on toxic elements, including pesticides, herbicides, fungicides, plasticizer accumulation and heavy-metal contamination. A comprehensive study was conducted at various recently developed societies of Sadiqabad that were formerly used for agricultural purposes. Ten various societies were selected, and three samples from each society were collected from different regions of these areas. Data regarding the physicochemical properties, metal contamination and accumulation of pesticide residues were determined using standard protocols. The results revealed that almost all the physicochemical properties of water samples selected from these sites were close to the WHO’s recommended limits. The range for physicochemical properties was pH (6.4–7.7), electrical conductivity (168–766 µ S cm−1), turbidity (6–17 NTU), total hardness (218–1030 mg L−1), chloride contents (130–870 mg L−1) and phosphate contents (2.55–5.11 mg L−1). Among heavy metals, lead and arsenic concentrations in all sampling sites were found to be above the recommended limits. The decreasing pattern in terms of water-quality deterioration with respect to physicochemical properties was FFT > USM > CRH > UCS > CHS > MAH > FFC > CGA > GIH > AGS. Overall, 95 different kinds of toxic elements, including pesticides, herbicides, plasticizer, etc., were detected in the groundwater samples. The toxic compounds in the groundwater were categorized into pesticides, herbicides, plasticizer, plant growth regulators, fungicides, acaricides and insecticides. Most of these parameters showed peak values at the Fatima Fertilizer Company area and Chief Residencia Housing Society. Pesticide contamination showed that water-filtration plants have a big positive impact on the drinking quality of water. Proper monitoring of the pesticides must be performed, as the majority of the pesticides showed low priority. The monitoring method of the pesticides needs to be updated so that the occurrence of recently authorized pesticides is demonstrated.

show abstract

Estrogen receptor: A potential linker of estrogenic and dopaminergic pathways in zebrafish larvae following deltamethrin exposure

Qiao

et al. 2022

Science of The Total Environment

View full text Add to dashboard Cite

Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors α and β: A Fluorescence Polarization Assay

Cited by 4 publications

References 0 publications

Phenotypic malignant changes and untargeted lipidomic analysis of long-term exposed prostate cancer cells to endocrine disruptors

Phenotypic malignant changes and untargeted lipidomic analysis of long-term exposed prostate cancer cells to endocrine disruptors

Pesticides, Heavy Metals and Plasticizers: Contamination and Risk Assessment of Drinking-Water Quality

Estrogen receptor: A potential linker of estrogenic and dopaminergic pathways in zebrafish larvae following deltamethrin exposure

Contact Info

Product

Resources

About