Estrogen receptor: A potential linker of estrogenic and dopaminergic pathways in zebrafish larvae following deltamethrin exposure

Hu, Tiantian; Ma, Yongfang; Qiao, Kun; Jiang, Yao; Li, Shuying; Gui, Wenjun; Zhu, Guonian

doi:10.1016/j.scitotenv.2021.149938

Cited by 8 publications

(7 citation statements)

References 36 publications

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“…An increase in the thigmotaxis of zebrafish larvae (preference for the walls) has been observed after treatment with low concentrations of DM (0.1, 1 and 10 μg L −1 ), while at high concentrations (25 and 50 μg L −1 ) the activity decreased [ 38 ]. A similar result was found by Hu et al [ 43 ] where they documented significantly reduced average swimming speed of zebrafish larvae exposed to DM at 25 μg L −1 . Moreover, the results showed that the locomotor activity of zebrafish larvae and the transcript levels of the components of estrogenic and dopaminergic pathways were altered by DM exposure.…”

Section: Introductionsupporting

confidence: 89%

“…The DM concentration in water samples ranged from ng L −1 to μg L −1 . Previous studies have reported that DM exposure could induce zebrafish developmental delay and malformation [ 38 , 39 , 40 ], apoptosis [ 38 , 40 ], cardiovascular toxicity [ 38 ], gonadotoxicity [ 41 ] as well as changes in neurochemical, behavioral and cognitive endpoints [ 20 , 38 , 39 , 42 , 43 , 44 ]. Hyperactivity and swimming towards the surfaces were observed in adult zebrafish after DM (>0.1 μg L −1 ) exposure [ 39 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin C Mitigates Oxidative Stress and Behavioral Impairments Induced by Deltamethrin and Lead Toxicity in Zebrafish

Paduraru

Elena-Iuliana

Lazado

et al. 2021

IJMS

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Environmental contamination from toxic metals and pesticides is an issue of great concern due to their harmful effects to human health and the ecosystems. In this framework, we assessed the adverse effects when aquatic organisms are exposed to toxicants such as deltamethrin (DM) and lead (Pb), alone or in combination, using zebrafish as a model. Moreover, we likewise evaluated the possible protective effect of vitamin C (VC) supplementation against the combined acute toxic effects of the two toxicants. Juvenile zebrafish were exposed to DM (2 μg L−1) and Pb (60 μg L−1) alone and in combination with VC (100 μg L−1) and responses were assessed by quantifying acetylcholinesterase (AChE) activity, lipid peroxidation (MDA), some antioxidant enzyme activities (SOD and GPx), three-dimension locomotion responses and changes of elements concentrations in the zebrafish body. Our results show that VC has mitigative effects against behavioral and biochemical alterations induced by a mixture of contaminants, demonstrating that it can be used as an effective antioxidant. Moreover, the observations in the study demonstrate zebrafish as a promising in vivo model for assessing the neuroprotective actions of bioactive compounds.

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Section: Introductionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Vitamin C Mitigates Oxidative Stress and Behavioral Impairments Induced by Deltamethrin and Lead Toxicity in Zebrafish

Paduraru

Elena-Iuliana

Lazado

et al. 2021

IJMS

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“…42 Del acts on the estrogenic signaling pathways through the ligation of estrogen receptors in zebrafish larvae. 43 However, the antagonistic effects of Del on estrogen receptors in CHO-1 cells have also been reported. 44 Del has been reported to antagonize the effects of androgen receptors.…”

Section: Discussionmentioning

confidence: 99%

“…The endocrine toxicity of pyrethroid in fish has long been summarized via interference with endogenous hormones and upstream signaling pathways 42 . Del acts on the estrogenic signaling pathways through the ligation of estrogen receptors in zebrafish larvae 43 . However, the antagonistic effects of Del on estrogen receptors in CHO‐1 cells have also been reported 44 .…”

Section: Discussionmentioning

confidence: 99%

Effect of chronic deltamethrin exposure on brain transcriptome and metabolome of juvenile crucian carp

Wu,

Gao,

Xie

et al. 2023

Environmental Toxicology

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Deltamethrin (Del), a widely administered pyrethroid insecticide, has been established as a common contaminant of the freshwater environment and detected in many freshwater ecosystems. In this study, we investigated the changes in brain transcriptome and metabolome of crucian carp after exposure to 0.6 μg/L Del for 28 days. Elevated MDA levels and inhibition of SOD activity indicate damage to the antioxidant system. Moreover, a total of 70 differential metabolites (DMs) were identified using the liquid chromatography‐mass spectrometry, including 32 upregulated and 38 downregulated DMs in the Del‐exposed group. The DMs associated with chronic Del exposure were enriched in steroid hormone biosynthesis, fatty acid metabolism, and glycerophospholipid metabolism for prostaglandin G2, 5‐oxoeicosatetraenoic acid, progesterone, androsterone, etiocholanolone, and hydrocortisone. Transcriptomics analysis revealed that chronic Del exposure caused lipid metabolism disorder, endocrine disruption, and proinflammatory immune response by upregulating the pla2g4, cox2, log5, ptgis, lcn, and cbr expression. Importantly, the integrative analysis of transcriptomics and metabolomics indicated that the arachidonic acid metabolism pathway and steroid hormone biosynthesis were decisive processes in the brain tissue of crucian carp after Del exposure. Furthermore, Del exposure perturbed the tight junction, HIF‐1 signaling pathway, and thyroid hormone signaling pathway. Overall, transcriptome and metabolome data of our study offer a new insight to assess the risk of chronic Del exposure in fish brains.

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“…In 2021, the global market share of pyrethroids was US$ 3.4 billion and is predicted to reach US$ 4.5 billion by 2027 . Deltamethrin (DM) is one of the most widely used type II synthetic pyrethroids because of its high activity against insect pests and its photostability, , resulting in frequent detections in surface waters. Concentrations have been observed to range from ng/L to μg/L. − For example, high levels of DM have been measured in channels nearby industrial areas (4317 μg/L in Italy) .…”

Section: Introductionmentioning

confidence: 99%

Contribution of Immune Responses to the Cardiotoxicity and Hepatotoxicity of Deltamethrin in Early Life Stage Zebrafish (Danio rerio)

Wang,

Li,

Liu

et al. 2024

Environ. Sci. Technol.

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Deltamethrin (DM) is a widely used insecticide that has demonstrated developmental toxicity in the early life stages of fish. To better characterize the underlying mechanisms, embryos from Tg(cmlc2:RFP), Tg(apo14:GFP), and Tg(mpx:GFP) transgenic strains of zebrafish were exposed to nominal DM concentrations of 0.1, 1, 10, 25, and 50 μg/L until 120 h postfertilization (hpf). Heart size increased 56.7%, and liver size was reduced by 17.1% in zebrafish exposed to 22.7 and 24.2 μg/L DM, respectively. RNA sequencing and bioinformatic analyses predicted that key biological processes affected by DM exposure were related to inflammatory responses. Expression of IL-1 protein was increased by 69.0% in the 24.4 μg/L DM treatment, and aggregation of neutrophils in cardiac and hepatic histologic sections was also observed. Coexposure to resatorvid, an antiinflammatory agent, mitigated inflammatory responses and cardiac toxicity induced by DM and also restored liver biomass. Our data indicated a complex proinflammatory mechanism underlying DM-induced cardiotoxicity and hepatotoxicity which may be important for key events of adverse outcomes and associated risks of DM to early life stages of fish.

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Estrogen receptor: A potential linker of estrogenic and dopaminergic pathways in zebrafish larvae following deltamethrin exposure

Cited by 8 publications

References 36 publications

Vitamin C Mitigates Oxidative Stress and Behavioral Impairments Induced by Deltamethrin and Lead Toxicity in Zebrafish

Vitamin C Mitigates Oxidative Stress and Behavioral Impairments Induced by Deltamethrin and Lead Toxicity in Zebrafish

Effect of chronic deltamethrin exposure on brain transcriptome and metabolome of juvenile crucian carp

Contribution of Immune Responses to the Cardiotoxicity and Hepatotoxicity of Deltamethrin in Early Life Stage Zebrafish (Danio rerio)

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