Binding of Nickel and Copper to Fish Gills Predicts Toxicity When Water Hardness Varies, But Free-Ion Activity Does Not

Meyer, Joseph S.; Santore, Robert C.; Bobbitt, Joe P.; DeBrey, Larry D.; Boese, Connie J.; Paquin, Paul; Allen, Herbert E.; Bergman, Harold L.; DiToro, Dominic M.

doi:10.1021/es980715q

Cited by 189 publications

(110 citation statements)

References 12 publications

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“…Concentration of extracellular Cu is probably a better indicator because it does not need to consider the matrix effects in aqueous phase. Meyer et al (1999) used fathead minnows (Pimephales promelas ) to evaluate Cu toxicity and found that concentration of Cu bounded on fish gill ([Cu gill ]) was constant predictors of toxicity when the Ca concentration increases, whereas the free-ion activities of Cu are not constant predictors of toxicity. Di Toro (2001) used larval fathead minnow to observe the effect of variations in DOC concentration on LC 50 of Cu and found that the gill Cu concentration can be used to predict acute mortality.…”

Section: Resultsmentioning

confidence: 99%

Accumulation, assimilation and growth inhibition of copper on freshwater alga (Scenedesmus subspicatus 86.81 SAG) in the presence of EDTA and fulvic acid

Zhu

Wang

et al. 2003

Aquatic Toxicology

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Accumulation and growth inhibition of Cu to fresh water alga (Scenedesmus subspicatus 86.81 SAG) and the influences of ethylenediaminetetraacetic acid (EDTA) and fulvic acid (FA) were examined. These results demonstrated that both EDTA and FA could reduce toxicity of Cu to alga by the way of preventing Cu from being adsorbed by cell wall of alga. When dissolved Cu (Cu dissolved ), extracellular Cu (Cu extracellular ), and intracellular Cu (Cu intracellular ) were differentiated, our results showed that the concentration level of extracellular Cu ([Cu extracellular ]) was a good indicator for measuring the toxic effects of Cu on alga growth in complex matrix. Either in the absence or in the presence of EDTA and FA, the concentration of intracellular Cu increased to 0.6 Á/1.5 )/10 (8 mM per cell when the growth inhibition reached to about 50%. We found that the acute toxicity of copper on unicellular alga could be interpreted by its accumulation at a discrete site or biotic ligand at alga cell wall and critical accumulation of Cu associated with EC 50 was determined to be 1 )/10 (8 mM per cell. Therefore, the Biotic Ligand Model (BML) could be extended to predict the influence of copper on growth inhibition of alga. #

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Section: Resultsmentioning

confidence: 99%

Accumulation, assimilation and growth inhibition of copper on freshwater alga (Scenedesmus subspicatus 86.81 SAG) in the presence of EDTA and fulvic acid

Zhu

Wang

et al. 2003

Aquatic Toxicology

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“…[103] For copper, cadmium, and nickel, a strong relationship has been observed between metal accumulation on the gills of rainbow trout or fathead minnows and that predicted using acute toxicity data. [31,40,57,131] Furthermore, physiologically based log K values (log K Ag-gill ATPase = 7.6) have been shown to be useful for predicting the silver binding to specific toxic sites of the gills of rainbow trout. [132] Future research will most certainly need to move beyond total body burdens and total bioaccumulation.…”

Section: Conclusion and Future Research Directionsmentioning

confidence: 99%

Predicting the Bioavailability of Metals and Metal Complexes: Critical Review of the Biotic Ligand Model

Slaveykova¹,

Wilkinson²

2005

Environ. Chem.

296

273

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Abstract. The biotic ligand model is a useful construct both for predicting the effects of metals to aquatic biota and for increasing our mechanistic understanding of their interactions with biological surfaces. Since biological effects due to metals are always initiated by metal bioaccumulation, the fundamental processes underlying bio-uptake are examined in this review. The model assumes that the metal of interest, its complexes, and metal bound to sensitive sites on the biological surface are in chemical equilibrium. Therefore, many of the equilibrium constants required for the model have been compiled and their methods of determination evaluated. The underlying equilibrium assumption of the BLM is also examined critically. In an attempt to identify which conditions are appropriate for its application, several documented examples of failures of the BLM are discussed. Finally, the review is concluded by identifying some important future research directions.

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“…These values were derived from the available literature at the time, but it is likely that consideration of more recent studies would result in significantly different values. Furthermore, enough data now may be available to derive at least a hardness-based criterion, if not even a criterion that considers the complexation of Al to biological surfaces such as fish gills (i.e., Meyer, 1999;Meyer et al, 1999).…”

Section: F Future Recommendationsmentioning

confidence: 99%

The Bioavailability and Toxicity of Aluminum in Aquatic Environments

Gensemer

Playle

1999

Critical Reviews in Environmental Science and Technology

629

444

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ABSTRACT:In this article we review the biological effects of Al, primarily with respect to the chemical factors controlling Al bioavailability and toxicity, and how its biological effects are best predicted. Our intent is not to duplicate recent reviews on Al chemistry or toxicity, but rather to update the literature since these reviews were published, and to focus on Al speciation and other external chemical influences on Al bioavailability to freshwater biota. Briefly, we first review Al chemistry, with a specific focus on understanding, as well as measuring, Al chemical species of importance to aquatic biota. Next we more comprehensively review Al toxicity and bioavailability to freshwater algae, with a thorough analysis of the relationships between speciation and toxicity, the role of important chemical complexing agents such as P, Si, and organic carbon, as well as the potential for Al to impact algal community structure. A third section reviews the more sparse literature on aquatic higher plants; the fourth section reviews a somewhat more abundant literature of Al toxicity to freshwater invertebrates. We close with an updated review of Al toxicity to fish, again with a focus on mechanisms of toxicity, and the role of Al speciation in controlling bioavailability.

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Binding of Nickel and Copper to Fish Gills Predicts Toxicity When Water Hardness Varies, But Free-Ion Activity Does Not

Cited by 189 publications

References 12 publications

Accumulation, assimilation and growth inhibition of copper on freshwater alga (Scenedesmus subspicatus 86.81 SAG) in the presence of EDTA and fulvic acid

Accumulation, assimilation and growth inhibition of copper on freshwater alga (Scenedesmus subspicatus 86.81 SAG) in the presence of EDTA and fulvic acid

Predicting the Bioavailability of Metals and Metal Complexes: Critical Review of the Biotic Ligand Model

The Bioavailability and Toxicity of Aluminum in Aquatic Environments

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