Binding of insecticides to human serum proteins

Skalsky, Harry L.; Guthrie, F. E.

doi:10.1016/0041-008x(78)90002-9

Cited by 58 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results obtained for DDT are in agreement with earlier observations (under comparable experimental conditions) of the relative affinity of DDT to albumin and VLDL+LDL fraction of human plasma (Morgan et al 1972;Skalsky and Guthrie 1978). However, 6-(14C)CB was reported to be distributed almost equally between different fractions of human plasma (Vomachka et al 1983).…”

Section: Discussionsupporting

confidence: 94%

Distribution of toxaphene, DDT, and PCB among lipoprotein fractions in rat and human plasma

et al. 1990

View full text Add to dashboard Cite

The distribution of 14C-toxaphene, 14C-DDT, and 14C-PCB among lipoprotein fractions was studied in vitro and in vivo using rat and human plasma. The association of these substances with rat plasma fractions was similar in both in vitro and in vivo experiments. Thirty-seven to fifty-two per cent of the total radioactivity was associated with the cholesterol-rich high density lipoproteins (HDL2, d = 1.075-1.21 g/ml) and 18-52% was recovered in the albumin-rich bottom fraction (BF, d greater than 1.21 g/ml). A time-dependent redistribution of the radioactivity from the lipoprotein fractions to the BF was also observed in the in vivo studies. In human plasma, the distribution of the three compounds was different and uncorrelated to the cholesterol level of the individual lipoprotein fractions. Toxaphene was almost equally distributed between BF (d greater than 1.21 ml), HDL (d = 1.063-1.21 g/ml) and low density lipoproteins (LDL, d = 1.006-1.063 g/ml) (26%, 27% and 29%, respectively), while only 18% appeared in the very low density lipoprotein (VLDL, d less than 1.006) fraction. In contrast, a large proportion of DDT and PCB radioactivity was recovered in the BF (52% and 62%, respectively) while only 38-48% was present in lipoprotein fractions. The complex nature of the interaction between xenobiotics and plasma lipoproteins is discussed.

show abstract

Section: Discussionsupporting

confidence: 94%

Distribution of toxaphene, DDT, and PCB among lipoprotein fractions in rat and human plasma

et al. 1990

View full text Add to dashboard Cite

show abstract

“…These chemicals circulate in the bloodstream, either bound to carrier proteins such as albumin and lipoproteins or in their free form, and distribute among tissue compartments throughout the body (2). Initially, the rate of distribution of chemicals within the body is a function of tissue perfusion, which is the rate of blood flow through the various tissues.…”

Section: Incorporation Of Environmental Chemicals Into Breast Milkmentioning

confidence: 99%

Analytic considerations for measuring environmental chemicals in breast milk.

Needham

Wang

2002

Environ Health Perspect

View full text Add to dashboard Cite

The presence of environmental chemicals in human breast milk is of general concern because of the potential health consequence of these chemicals to the breast-fed infant and the mother. In addition to the mother's exposure, several features determine the presence of environmental chemicals in breast milk and their ability to be determined analytically. These include maternal factors and properties of the environmental chemical--both physical and chemical--such as its lipid solubility, degree of ionization, and molecular weight. Environmental chemicals with high lipid solubility are likely to be found in breast milk; they include polyhalogenated compounds such as polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, organochlorine insecticides, and polybrominated diphenylethers. These fat-soluble chemicals are incorporated into the milk as it is synthesized, and they must be measured in accordance with the fat content of the milk to allow for meaningful comparisons within an individual and among populations. Although the analytic approach selected to measure the environmental chemical is predominantly determined by the characteristics of the chemical, the concentration of the chemical in the milk sample and the existence of structurally similar chemicals (e.g., congeners) must be considered as well. In general, the analytic approach for measuring environmental chemicals in breast milk is similar to the approach for measuring the same chemicals in other matrices, except special considerations must be given for the relatively high fat content of milk. The continued efforts of environmental scientists to measure environmental chemicals in breast milk is important for defining the true contribution of these chemicals to public health, especially to the health of the newborn. Work is needed for identifying and quantifying additional environmental chemicals in breast milk from the general population and for developing analytic methods that have increased sensitivity and the ability to speciate various chemicals.

show abstract

“…Whether free or bound to proteins such as albumin and lipoproteins, pollutants distribute throughout tissue compartments of the body. 18 Ingested chemicals are typically deposited into adipose tissue, from which it partitions into richly perfused tissue (a single compartment composed of the brain, kidney, intestines, liver and spleen) or instantaneously into muscle. As equilibrium states are reached, the chemicals redistribute, and chemicals with high lipid solubility concentrate in tissue with higher fat content, such as adipose tissue in the brain, liver, kidney, and in the case of lactating women, the mammary gland.…”

Section: Breastfeeding and Pollutant Pharmacokineticsmentioning

confidence: 99%