Binding of HeLa DNA‐polymerase α to blue dextran: A possible artefact in molecular weight determination by gel filtration

Brissac, C.; Rucheton, Marcel; Brunei, C.; Jeanteur, P

doi:10.1016/0014-5793(76)80166-4

Cited by 10 publications

(2 citation statements)

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“…146 In the same year, Haeckel et al reported a similar observation but for yeast pyruvate kinase. 147 Binding to blue dextran was also reported by others, for example, by Staal 152 In all reports, blue dextran binding was inhibited under conditions of high ionic strength.…”

Section: A Role Of Reactive Blue 2 In Protein Purificationsupporting

confidence: 56%

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Anthraquinones As Pharmacological Tools and Drugs

Malik

Müller

2016

Medicinal Research Reviews

345

211

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Anthraquinones (9,10-dioxoanthracenes) constitute an important class of natural and synthetic compounds with a wide range of applications. Besides their utilization as colorants, anthraquinone derivatives have been used since centuries for medical applications, for example, as laxatives and antimicrobial and antiinflammatory agents. Current therapeutic indications include constipation, arthritis, multiple sclerosis, and cancer. Moreover, biologically active anthraquinones derived from Reactive Blue 2 have been utilized as valuable tool compounds for biochemical and pharmacological studies. They may serve as lead structures for the development of future drugs. However, the presence of the quinone moiety in the structure of anthraquinones raises safety concerns, and anthraquinone laxatives have therefore been under critical reassessment. This review article provides an overview of the chemistry, biology, and toxicology of anthraquinones focusing on their application as drugs.

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Section: A Role Of Reactive Blue 2 In Protein Purificationsupporting

confidence: 56%

“…for human follicle‐stimulating hormone; and Brissac et al. for HeLa DNA‐polymerase α . In all reports, blue dextran binding was inhibited under conditions of high ionic strength.…”

Section: Anthraquinones As Biochemical and Pharmacological Tools: Reamentioning

confidence: 92%