Binding of Drugs by Albumin Plasma Protein

Biodistribution of Novel 68Ga-Radiolabelled HER2 Aptamers in Mice

“…The same behaviour has also been observed for a variety of drugs, such as aspirin [43,44]. Pre-or co-infusion with a non-targeting aptamer may be used to saturate blood proteins.…”

Strategy for analysis and screening of bioactive compounds in traditional Chinese medicines

“…Chaiken redefined the extension of affinity chromatography as molecular biochromatography that was described as "a means to use matrix-mobile interactant systems to study mechanisms of biomolecular interactions and therein to attain an understanding of such interactions which are often not easily achieved by solution method alone" [44]. As we know, most synthetic drugs bind, more or less, to plasma protein [45,46]. Albumin is the most abundant plasma protein and often accounts for the entire drug binding in plasma.…”

“…Studies on drug-protein binding are important in pharmacology and pharmacokinetics [45,46,73], because drug-protein interaction affects the pharmacological activities and side effects of the drug as well as the drug distribution and elimination. The unbound drug alone is supposed to diffuse from the blood to the extravascular active sites and to exhibit the pharmacological activity and/or the side effect.…”

Hydroxyl Radical (ºOH) Scavenger Power of Tris (hydroxymethyl) Compared to Phosphate Buffer

“…The normal concentration of this protein in human plasma is ranged between 35 and 50 g/l. Albumin has several important functions in physiological conditions like transferring metals, fatty acids (Curry, Brick, & Franks, 1999), cholesterol, bile pigments, and drugs (SUDLOW, BIRKETT, & WADE, 1976;Vallner, 1977). As this protein is continuously exposed to oxidative stress, a crucial part of antioxidant power of the human body is attributed to HSA (Bourdon & Blache, 2001;Friedrichs, 1997;Taverna, Marie, Mira, & Guidet, 2013).…”