Binding Mechanism Elucidation of the Acute Respiratory Disease Causing Agent Adenovirus of Serotype 7 to Desmoglein-2

Hograindleur, Marc-André; Effantin, Grégory; Fenel, Daphna; Mas, Caroline; Lieber, André; Schoehn, Guy; Fender, Pascal; Vassal-Stermann, Émilie

doi:10.3390/v12101075

Cited by 8 publications

(12 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…38 248 266 280 281 282 283 284 285 The enhanced virulence of AdV-7 may reflect attachment of AdV-7 knob domain to the cellular receptor desmoglein-2. 286 Epidemic AdV-7 infections have been reported in the United States, 5 256 Canada, 287 South America, 248 288 289 Australia, 290 Israel, 261 Korea, 65 164 Japan, 260 279 China, 172 258 281 Malaysia, 291 the Philippines, 292 and globally. 261 Outbreaks typically occur in closed settings (e.g., military barracks, 15 23 165 chronic care facilities, 51 hospitals 5 293 ).…”

Section: Global Epidemiologymentioning

confidence: 99%

Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment

Lynch

Kajon

2021

Semin Respir Crit Care Med

103

187

View full text Add to dashboard Cite

Adenoviruses (AdVs) are DNA viruses that typically cause mild infections involving the upper or lower respiratory tract, gastrointestinal tract, or conjunctiva. Rare manifestations of AdV infections include hemorrhagic cystitis, hepatitis, hemorrhagic colitis, pancreatitis, nephritis, or meningoencephalitis. AdV infections are more common in young children, due to lack of humoral immunity. Epidemics of AdV infection may occur in healthy children or adults in closed or crowded settings (particularly military recruits). The vast majority of cases are self-limited. However, the clinical spectrum is broad and fatalities may occur. Dissemination is more likely in patients with impaired immunity (e.g., organ transplant recipients, human immunodeficiency virus infection). Fatality rates for untreated severe AdV pneumonia or disseminated disease may exceed 50%. More than 100 genotypes and 52 serotypes of AdV have been identified and classified into seven species designated HAdV-A through -G. Different types display different tissue tropisms that correlate with clinical manifestations of infection. The predominant types circulating at a given time differ among countries or regions, and change over time. Transmission of novel strains between countries or across continents and replacement of dominant viruses by new strains may occur. Treatment of AdV infections is controversial, as prospective, randomized therapeutic trials have not been done. Cidofovir has been the drug of choice for severe AdV infections, but not all patients require treatment. Live oral vaccines are highly efficacious in reducing the risk of respiratory AdV infection and are in routine use in the military in the United States but currently are not available to civilians.

show abstract

Section: Global Epidemiologymentioning

confidence: 99%

Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment

Lynch

Kajon

2021

Semin Respir Crit Care Med

103

187

View full text Add to dashboard Cite

show abstract

“…Viruses infect using different host cell receptors, as has been reported for CoV through ACE2 [104]; RSV through C-X3-C Motif Chemokine Receptor 1 (CX3CR1) [105]; influenza virus, parainfluenza virus, and enterovirus through sialic acid [106][107][108]; metapneumovirus through integrins [109]; rhinovirus through low-density lipoprotein receptor (LDLR) and very-LDLR (VLDLR) [110]; and adenovirus through desmoglein [111].…”

Section: Roles In the Antiviral Response Mediated By Interferons (Ifn)-imentioning

confidence: 88%

How Micronutrients Fuel Immune System At the Molecular Level: An Approach to the Immune Response Against Respiratory Viruses

Jiménez-Uribe

Ocampo-Hernández

Aranciba-Hernández

et al. 2022

Cell Physiol Biochem

View full text Add to dashboard Cite

Viral respiratory infections could range from a common cold to severe pneumonia, and their resolution mainly relies on appropriate immune system function. The widespread popular knowledge that nutritional habits influence immune system function has been demonstrated over the past decades in which increasing scientific evidence unveils certain nutrients as critical drivers of immunity. Micronutrients encompass minerals and vitamins necessary for a broad range of biological processes; since their deficiency could cause several clinical manifestations, such as weakness, growth retardation, and susceptibility to infections; hence, micronutrients represent one of the multiple factors that modulate immune function. Among micronutrients are those that act mainly as antioxidants, regulating gene expression and as a structural part of proteins for their proper function. Here, we review how some of the most recognized micronutrients are participating at the molecular level in each step of the innate and adaptive immune response against viruses focusing on viral respiratory tract infections, such as those caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

show abstract

“…CVB is responsible for various diseases, including myocarditis, pancreatitis and meningitis [26]. DSG2 has been identified as the primary receptor for CVB [27]. The viral capsid protein of CVB, known as VP1, interacts with DSG2 on the surface of host cells, specifically cardiac and epithelial cells [28].…”

Section: Overview Of the Mechanism Of Sars-cov-2/dsg2-mediated Entry ...mentioning

confidence: 99%

Desmoglein-2 and COVID-19 complications: insights into its role as a biomarker, pathogenesis and clinical implications

Uchechukwu,

Anyaduba,

Udekwu

et al. 2023

Journal of General Virology

View full text Add to dashboard Cite

Desmoglein-2 (DSG2) has emerged as a potential biomarker for coronavirus disease 2019 (COVID-19) complications, particularly cardiac and cardiovascular involvement. The expression of DSG2 in lung tissues has been detected at elevated levels, and circulating DSG2 levels correlate with COVID-19 severity. DSG2 may contribute to myocardial injury, cardiac dysfunction and vascular endothelial dysfunction in COVID-19. Monitoring DSG2 levels could aid in risk stratification, early detection and prognostication of COVID-19 complications. However, further research is required to validate DSG2 as a biomarker. Such research will aim to elucidate its precise role in pathogenesis, establishing standardized assays for its measurement and possibly identifying therapeutic targets.

show abstract

Binding Mechanism Elucidation of the Acute Respiratory Disease Causing Agent Adenovirus of Serotype 7 to Desmoglein-2

Cited by 8 publications

References 53 publications

Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment

Adenovirus: Epidemiology, Global Spread of Novel Types, and Approach to Treatment

How Micronutrients Fuel Immune System At the Molecular Level: An Approach to the Immune Response Against Respiratory Viruses

Desmoglein-2 and COVID-19 complications: insights into its role as a biomarker, pathogenesis and clinical implications

Contact Info

Product

Resources

About