Desmoglein-2 and COVID-19 complications: insights into its role as a biomarker, pathogenesis and clinical implications
Chidiebere F. Uchechukwu,
Uchechukwu Love Anyaduba,
Chukwuemeka Chinedum Udekwu
et al.
Abstract:Desmoglein-2 (DSG2) has emerged as a potential biomarker for coronavirus disease 2019 (COVID-19) complications, particularly cardiac and cardiovascular involvement. The expression of DSG2 in lung tissues has been detected at elevated levels, and circulating DSG2 levels correlate with COVID-19 severity. DSG2 may contribute to myocardial injury, cardiac dysfunction and vascular endothelial dysfunction in COVID-19. Monitoring DSG2 levels could aid in risk stratification, early detection and prognostication of COV… Show more
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