Binding Interaction of Gatifloxacin with Bovine Serum Albumin

Guo, Ming; Zou, Jian-Wei; Yi, Pinggui; Shang, Zhicai; Hu, Guixiang; Q, Yu

doi:10.2116/analsci.20.465

Cited by 116 publications

(65 citation statements)

References 17 publications

(9 reference statements)

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“…If the KSV decreased with increased temperatures, it could be concluded that the quenching process is not a dynamic quenching but a static quenching. [5][6][7][8] For dynamic quenching, the mechanism can be described by the Stern-Volmer equation:…”

Section: Resultsmentioning

confidence: 99%

“…Extensive investigations into the interaction between the serum albumin and internal compound or pharmaceutical molecules have been made. [3][4][5][6][7] But so far only a few reports on the reactions between the effective component in Chinese herbal medicines and serum albumin have been reported. [8][9][10] Fluorescence spectroscopy (FS) and ultraviolet spectroscopy (UV) have been widely used to study the interactions between the small molecules and bio-macromolecules.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Fluorescence spectroscopy (FS) and ultraviolet spectroscopy (UV) have been widely used to study the interactions between the small molecules and bio-macromolecules. [3][4][5][6][7][8][9][10] From the measurements and analyses of the fluorescence emission spectra, the fluorescence lifetime, fluorescence polarization, etc., a vast amount of information can be procured about the structural fluctuations and the microenvironment changes surrounding the fluorophore in the macromolecule. [3][4][5][6][7][8][9][10][11][12] In this study, the interaction of TET with HSA has been investigated by using FS and UV.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10] From the measurements and analyses of the fluorescence emission spectra, the fluorescence lifetime, fluorescence polarization, etc., a vast amount of information can be procured about the structural fluctuations and the microenvironment changes surrounding the fluorophore in the macromolecule. [3][4][5][6][7][8][9][10][11][12] In this study, the interaction of TET with HSA has been investigated by using FS and UV. The experimental results showed that TET could quench the inner fluorescence of HSA and that both static quenching and non-radiation energy transfer were the main reasons resulting in the fluorescence quenching.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Interaction of Tetrandrine with Human Serum Albumin: a Fluorescence Quenching Study

Wang

et al. 2007

ANAL. SCI.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interaction of Tetrandrine with Human Serum Albumin: a Fluorescence Quenching Study

Wang

et al. 2007

ANAL. SCI.

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“…So high temperature mean more diffusion coefficient. However the bimolecular quenching constant are expected to increase with temperature while if (Ksv) decrease with increase temperature, the quenching process is static rather than dynamic [32,33,34]. Statics quenching implies either existence of a sphere of effective quenching where dynamics or collisional quenching involve the collision followed by the formation of a transient complex between an excited-state fluorophore and a ground state quencher.…”

Section: Luminescence Quenching and Calibration Curve For Organophospmentioning

confidence: 99%

New High Throughput Microtiter Plates for Detection of Organophosphorous Pesticides in Environmental Samples.

Abd-el-Kader¹

2017

IJPSR

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Quenching of lanthanides luminescence of a novel long live Tb(III) -Ethyl 1-Allyl-1,2-Dihydro-4-Hydroxy-2-Oxoquinoline-3-Carboxylate (EADHOC) as a ligand to form a complex with molar ratio 1:3 in solution has been studied in ethanol in presence of organophosphorus pesticides both Di-chlorvos(P1) and paraoxon-Ethyl (P2). The intensity of luminescence of Tb(III) -(EADHOC) decrease as the concentration of pesticides increase. The quenching effect was observed with both pesticides. Direct methods of determination of pesticides under investigated have been developed by using luminescence of Tb(III) -(EADHOC) probe in a solution. The linear range for determination of the selected pesticides P1(Di-chlorovos) and P2(Paraoxon-Ethyl) is1 to 7 and 1 to 10 µM. the detection limits were 1.9×10-7and 9.8×10-7 µM for P1(Di-chlorovos) and P2(Paraoxon-Ethyl) respectively. The Thermodynamic parameters and binding constant (K) of OPs with Tb(III) -(EADHOC) were evaluated. Including the value of enthalpy (∆H ) and entropy( ∆S ) changes for Probe interaction with pesticides. As the natural water sample in this study don't contain the above mentioned OPs over the limit detected by the methods, a recovery study was carried out after the addition of the adequate amount of organophosphorus pesticides.

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Antimicrobial and antibiofilm activities and bovine serum albumin binding properties of benzimidazolium derivative NHC salts and their Ag(I)‐NHC complexes

Çelik

Üstün

Şahin

et al. 2022

Applied Organom Chemis

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Benzimidazole type N‐heterocyclic carbene molecules and their metal complexes have well‐known biological activity. Elemental silver and silver complexes also have antibacterial and antifungal activity. In this study, silver complexes with 1‐allyl 5,6‐dimethylbenzimidazolium derivative ligands were analyzed for their antimicrobial and antibiofilm activities. Additionally, bovine serum albumin (BSA) binding properties of the molecules were analyzed by spectrophotometric methods, and the details of interactions of the molecules with BSA were investigated by molecular docking methods. While N‐heterocyclic carbene salts showed moderate antifungal and antibiofilm activity, silver complexes of these salts have strong antimicrobial activity with <1.9–15.6 μg/ml minimal inhibitory concentration (MIC) values. On the other hand, carbene salts have better affinity against BSA than the complexes. Additionally, the interaction of the optimized complexes with SarA and BSA were analyzed by molecular docking methods. According to in vitro and in silico evaluation, the studied Ag complexes may be utilized for advanced studies.

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Binding Interaction of Gatifloxacin with Bovine Serum Albumin

Cited by 116 publications

References 17 publications

Interaction of Tetrandrine with Human Serum Albumin: a Fluorescence Quenching Study

Interaction of Tetrandrine with Human Serum Albumin: a Fluorescence Quenching Study

New High Throughput Microtiter Plates for Detection of Organophosphorous Pesticides in Environmental Samples.

Antimicrobial and antibiofilm activities and bovine serum albumin binding properties of benzimidazolium derivative NHC salts and their Ag(I)‐NHC complexes

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