Binding constant and transport property of S-Naproxen molecularly imprinted composite membrane

Wang, Jingyu; Xu, Zheng; Wu, Ping; Yin, Shouchun

doi:10.1016/j.memsci.2009.01.016

Cited by 27 publications

(7 citation statements)

References 24 publications

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“…It was also of great importance to select an appropriate immersion time in polymerization solution for the PVDF membrane to obtain a good pre-polymerization support. In accordance with the literature synthesis procedures [ 35 , 36 ], it was found that the optimal polymerization time, at 60 °C, was 46 h. By varying the pre-polymerization and polymerization time, MIMs with modification degree ( D m ) of 2.40 mg/cm 2 were prepared, while the D m for the non-imprinted membranes was 2.52 mg/cm 2 . Using shorter polymerization times, lower D m , associated with a limited repeatability, were measured This indicates that MIMs and NIMs have the similar thickness of the coating layer and the modest difference may come from the washing procedure, after which the recognition cavities and molecular paths are formed in the imprinted layer [ 37 ].…”

Section: Resultsmentioning

confidence: 78%

“…As shown in Figure 7 , the 2-dA imprinted membrane exhibited relatively high binding affinities for 2-dA, while it did not show any binding capacity towards the other compounds. The reason for this is that the MIM can recognize its template molecule due to the existence of memory cavities of fixed size and shape, binding sites, and specific binding interactions between the target molecule and sites [ 35 ]. Also as expected, the non-imprinted (NIM) and the blank PVDF membranes did not show any binding capacity for these nucleosides.…”

Section: Resultsmentioning

confidence: 99%

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Molecularly Imprinted Composite Membranes for Selective Detection of 2-Deoxyadenosine in Urine Samples

Scorrano

Mergola

Bello

et al. 2015

IJMS

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An important challenge for scientific research is the production of artificial systems able to mimic the recognition mechanisms occurring at the molecular level in living systems. A valid contribution in this direction resulted from the development of molecular imprinting. In this work, a novel molecularly imprinted polymer composite membrane (MIM) was synthesized and employed for the selective detection in urine samples of 2-deoxyadenosine (2-dA), an important tumoral marker. By thermal polymerization, the 2-dA-MIM was cross-linked on the surface of a polyvinylidene-difluoride (PVDF) membrane. By characterization techniques, the linking of the imprinted polymer on the surface of the membrane was found. Batch-wise guest binding experiments confirmed the absorption capacity of the synthesized membrane towards the template molecule. Subsequently, a time-course of 2-dA retention on membrane was performed and the best minimum time (30 min) to bind the molecule was established. HPLC analysis was also performed to carry out a rapid detection of target molecule in urine sample with a recovery capacity of 85%. The experiments indicated that the MIM was highly selective and can be used for revealing the presence of 2-dA in urine samples.

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Section: Resultsmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Molecularly Imprinted Composite Membranes for Selective Detection of 2-Deoxyadenosine in Urine Samples

Scorrano

Mergola

Bello

et al. 2015

IJMS

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“…Composite MIMs imprinted with S-naproxen were prepared by Donato et al by photo-copolymerization of polypropylene with the functional monomer 4-vinylpiridine [154]. More recently, Wang and co-workers produced S-naproxen-imprinted hollow fibres using PVDF as membrane forming matrix [155]. Authors applied the thermal polymerization.…”

Section: Molecularly Imprinted Membranesmentioning

confidence: 99%

Emerging Tools for Recognition and/or Removal of Dyes from Polluted Sites: Molecularly Imprinted Membranes

Algieri

Drioli

Ahmed

et al. 2014

J. Memb. Separ. Tech.

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Dyes are used in different industries as textile, paper, food processing, cosmetic, leather tanning, rubber, printing and so on. These chemical substances have negative effect on the quality of the water and food, causing human diseases and environmental problems. In view of these aspects, colorant have attracted the interest of the scientists in developing efficient routes for their detection and/or removal from the polluted sites. Although traditional technologies used for removal of dyes are efficient, there is the necessity of developing innovative systems both more cheaply and of easy performance. In this scenario, the integration of the membrane science with the molecular imprinting technology is an alternative way that present many advantages such us the removal or detection of a specific dye or a class of dyes and cost reduction processes. In fact, exploiting the benefits of these two technologies it is possible to develop molecularly imprinted membranes able to recognize a dye of interest in specific mode. This potential is promising for combatting the illegal use of dyes in food, drinks and aquaculture as well as for their removal. The main positive aspects of the imprinted membranes are their chemical stability, reusability, as well as the resistance to the pH and temperature. In addition, their preparation requires short operation time and it is not expensive. All these properties have an encouraging impact in dealing with the problem of dyes contamination. This short review offers a description of the concept of molecular imprinting, starting from the approach of the synthesis of imprinted polymers until the description of the preparation of imprinted membranes. The application of imprinted polymers and membranes for the detection and/or removal of dyes from polluted sites will be also discussed.

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“…However, there are very few recent studies on the occurrence of ketoprofen in South African aqueous environments (Agunbiade and Moodley, 2016;Madikizela et al, 2014;Zunngu et al, 2017). In surface water and wastewater, ketoprofen is usually detected with other non-steroidal antiinflammatory drugs (NSAIDs) (Laven et al, 2009;Togola et al, 2007;Yu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Application of molecularly imprinted polymer designed for the selective extraction of ketoprofen from wastewater

Madikizela

Zunngu

Mlunguza

et al. 2018

WSA

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A molecularly imprinted polymer (MIP) that is selective to ketoprofen was synthesized and applied in the adsorption of the target compound from water. The MIP was synthesized using a bulk polymerization method at high temperatures (60–80°C), where ketoprofen, 2-vinylpyridine, ethylene glycol dimethacrylate, toluene and 1,1´-azobis(cyclohexanecarbonitrile) were used as template, functional monomer, cross-linker, porogen and initiator, respectively. Non-imprinted polymer (NIP) was synthesized similarly to the MIP but in the absence of ketoprofen. From molecular dynamics simulation, the nature of interactions that occurred between the template and the functional monomer were found to be based on hydrogen bonding. This was confirmed experimentally, where a high extraction efficiency of ≥ 90% was obtained at acidic conditions (pH 5) due to the protonation of ketoprofen. A contact time of 45 min was sufficient for the maximum adsorption of ketoprofen from 10 mL spiked water using 8 mg of the adsorbent. MIP showed greater selectivity than NIP by achieving a relative selectivity coefficient of 7.7 towards ketoprofen in the presence of structurally related pharmaceuticals. Furthermore, the order of sorption onto the MIPs from water was ketoprofen > fenoprofen > gemfibrozil. From a modelling perspective, the Langmuir adsorption isotherm and pseudo-second-order kinetic model gave the best fit, with maximum adsorption capacity of 8.24 mg·g−1 and sorption rate constant of 0.25 mg·g−1·min−1 for MIP. This was translated to chemisorption of ketoprofen onto the homogeneous MIP binding sites. This work demonstrated the great potential of MIP in selective recognition of ketoprofen from wastewater relative to closely related compounds.

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Binding constant and transport property of S-Naproxen molecularly imprinted composite membrane

Cited by 27 publications

References 24 publications

Molecularly Imprinted Composite Membranes for Selective Detection of 2-Deoxyadenosine in Urine Samples

Molecularly Imprinted Composite Membranes for Selective Detection of 2-Deoxyadenosine in Urine Samples

Emerging Tools for Recognition and/or Removal of Dyes from Polluted Sites: Molecularly Imprinted Membranes

Application of molecularly imprinted polymer designed for the selective extraction of ketoprofen from wastewater

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