Binding and metabolism of testosterone in the rat brain during sexual maturation—II. Testosterone metabolism

Loras, B; Genot, A.; Monbon, M.; Buecher, F.; Reboud, Jean‐Paul; Bertrand, J

doi:10.1016/0022-4731(74)90039-9

Cited by 17 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to become active, some of the gonadal steroids undergo prior metabolic transformation. Thus testosterone is converted into 5u-dihydrotestosterone in the prostate and the external genitalia, into 3a-5a-androstenediol in the pituitary (Loras et al, 1974;Massa et al, 1975), and into oestrogen in the pituitary and hypothalamus (Naftolin et al, 1971). These hormones also regulate their own secretion by a dual mechanism of positive and negative feedback that is exerted centrally at extra-hypothalamic, hypothalamic and pituitary sites.…”

Section: (C) Peripheral Levelmentioning

confidence: 99%

Hypothalamic‐pituitary‐gonadal Relationships in Man From Birth to Puberty

Forest

Peretti

Bertrand

1976

Clinical Endocrinology

134

View full text Add to dashboard Cite

Gonadal function depends upon activities at various levels. Thus there is: (a) a central level (extra-hypothalamic, hypothalamic, and anterior pituitary); (b) an intermediate level (gonadal and plasma), and (c) a peripheral level consisting of the target organs to which the hormonal message is directed. These determine both the expression of gonadal function (physical, physiological, or psychological) and the feedback regulation of the secretion of gonadotrophins.(a) Central level (i) Extra-hypothalamic centres. The production of LH releasing hormone (LHRH) is affected in the rat, and probably in primates as well, by extra-hypothalamic stimuli coming, in particular, from the amygdala and the hippocampus. Adrenergic regulation exists at this level, noradrenaline having a stimulatory and dopamine an inhibitory effect (Bliss et al., 1972).(ii) Hypothalamic centres. These are localized in particular in the pre-optic area. Immunochemical techniques have demonstrated that LHRH is secreted by neurones of the arcuate nucleus, and released into the capillary plexus proximal to the hypophyseal portal system at the level of the median eminence, thereby reaching the anterior pituitary (Barry & Dubois, 1974;Setalo et al., 1975).(iii) Gonadotrophin secreting cells of the anterior pituitary. These synthesize and secrete the gonadotrophins, LH and FSH, under the influence of LHRH (Schally et al., 1972). The pituitary gonadotrophins stimulate the synthesis and the secretion of the gonadal

show abstract

Section: (C) Peripheral Levelmentioning

confidence: 99%

Hypothalamic‐pituitary‐gonadal Relationships in Man From Birth to Puberty

Forest

Peretti

Bertrand

1976

Clinical Endocrinology

134

View full text Add to dashboard Cite

show abstract

“…The discovery of androgen metabolism in rat brain in the late 1960s [58] has attracted much attention to this problem. The metabolism of testosterone was found in many brain structures [ 19,23,45,47,51,55,57], in particular in rat pituitary gland. The intensity of testosterone metabolism in the pituitary gland of male rats is 1/5 of that in the prostate, the main androgen target tissue [22].…”

mentioning

confidence: 99%

Metabolism of androgens in rat pituitary gland and hypothalamus: Catabolism of dihydrotestosterone or transformation of androgen signal?

Degtyar

Kushlinskii

2000

Bull Exp Biol Med

View full text Add to dashboard Cite

The role of androgen metabolism and individual androgen metabolites in rat pituitary gland and hypothalamus is discussed on the basis of published data and results of our experiments. It is proposed that metabolism of androgens in these structures is aimed at the formation of not only true sex steroids estradiol-17 beta and 5 alpha-dihydrotestosterone, but also of androgens contributing to the regulation of cell processes, i.e. represents modification (transformation) of androgen signal (testosterone) in target pituitary and hypothalamic cells.

show abstract