Metabolism of androgens in rat pituitary gland and hypothalamus: Catabolism of dihydrotestosterone or transformation of androgen signal?

Degtyar, V. G.; Kushlinskii, N. E.

doi:10.1007/bf02439786

Cited by 2 publications

(2 citation statements)

References 57 publications

(74 reference statements)

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“…Breeding females and helpers showed a slight but significant decrease from the breeding to the non-breeding season. Testosterone might not be the most important androgen in female rodents (Degtyar and Kushlinskii, 2000), but my study provides further evidence that testosterone plays an also important role in female physiology (Staub and Beer, 1997).…”

Section: Testosterone Levels: Influences Of Social Class and Seasonmentioning

confidence: 68%

Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent

Schradin

2008

Hormones and Behavior

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Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent Schradin, C Schradin, C (2008). Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent. Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent AbstractAnimals have to adjust their physiology to seasonal changes, in response to variation in food availability, social tactics and reproduction. I compared basal corticosterone and testosterone levels in free ranging striped mouse from a desert habitat, comparing between the sexes, breeding and philopatric non-breeding individuals, and between the breeding and the non-breeding season. I expected differences between breeders and non-breeders and between seasons with high and low food availability. Basal serum corticosterone was measured from 132 different individuals and serum testosterone from 176 different individuals of free living striped mice. Corticosterone and testosterone levels were independent of age, body weight and not influenced by carrying a transmitter. The levels of corticosterone and testosterone declined by approximately 50% from the breeding to the non-breeding season in breeding females as well as non-breeding males and females. In contrast, breeding males showed much lower corticosterone levels during the breeding season than all other classes, and were the only class that showed an increase of corticosterone from the breeding to the non-breeding season. As a result, breeding males had similar corticosterone levels as other social classes during the non-breeding season. During the breeding season, breeding males had much higher testosterone levels than other classes, which decreased significantly from the breeding to the non-breeding season. My results support the prediction that corticosterone decreases during periods of low food abundance. Variation in the pattern of hormonal secretion in striped mice might assist them to cope with seasonal changes in energy demand in a desert habitat. AbstractAnimals have to adjust their physiology to seasonal changes, in response to variation in food availability, social tactics and reproduction. I compared basal corticosterone and testosterone levels in free ranging striped mouse from a desert habitat, comparing between the sexes, breeding and philopatric non-breeding individuals, and between the breeding and the non-breeding season. I expected differences between breeders and nonbreeders and between seasons with high and low food availability. Basal serum corticosterone was measured from 132 different individuals and serum testosterone from 176 different individuals of free living striped mice. Corticosterone and testosterone levels were independent of age, body weight and not influenced by carrying a transmitter.The levels of corticosterone and testosterone declined by approximately 50% from the breeding to the non-breeding season in breeding females as well as n...

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Section: Testosterone Levels: Influences Of Social Class and Seasonmentioning

confidence: 68%

Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent

Schradin

2008

Hormones and Behavior

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“…5a-Dihydrotestosterone formed in androgen-target cells is an exception to this, retaining potent activity even though the D 4 double bond is reduced. 5a-Dihydrotestosterone is even claimed to be the true androgen hormone (Degtyar et al, 2006).…”

Section: Functional Groupsmentioning

confidence: 99%

Structure and Nomenclature of Steroids

Kasal¹

2010

Steroid Analysis

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A formula of a steroid compound is easily recognized by its four-membered hydrocarbon core (Fig. 1.1a). My little grand daughter called it "a little cottage", more advanced beginners may recall the term "cyclopentenoperhydrophenanthrene". All the thousands of natural and synthetic steroids are derivatives of that core. Ring A is the cyclohexane ring on the left; it is attached to another six-membered ring B. The C ring follows, the D ring is a cyclopentane system. Numbering of the core is shown in the most prolific steroid-cholesterol (Fig. 1.1b): it starts at the A ring, continues at B, C, and then D rings. Methyl groups at angular positions 13 and 10 are ascribed numbers 18 and 19, the numbering then continues in the side chain. The numbers are used to describe positions at which substituents or multiple bonds are attached in individual compounds. Most steroid compounds are derived from the following six basic hydrocarbons:

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Metabolism of androgens in rat pituitary gland and hypothalamus: Catabolism of dihydrotestosterone or transformation of androgen signal?

Cited by 2 publications

References 57 publications

Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent

Seasonal changes in testosterone and corticosterone levels in four social classes of a desert dwelling sociable rodent

Structure and Nomenclature of Steroids

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