Binary Micelles (E45s8/F127) for Quercetin and Griseofulvin Solubilisation

Facile production of quercetin nanoparticles using 3D printed centrifugal flow reactors

“…This is largely because API nanocrystals with diameter < 50 nm, are substantially unreported in the literature. 64–67 Consistent with previous investigations, 68–70 it is likely that the produced samples contained polymeric micelles capable of solubilising quercetin in the formulation, thus preventing it from precipitating and forming nanocrystals. This hypothesis is supported by data from the literature, 69,70 reporting on the solubilization of quercetin in both KP407 and Pluronic P123 micelles.…”

“…64–67 Consistent with previous investigations, 68–70 it is likely that the produced samples contained polymeric micelles capable of solubilising quercetin in the formulation, thus preventing it from precipitating and forming nanocrystals. This hypothesis is supported by data from the literature, 69,70 reporting on the solubilization of quercetin in both KP407 and Pluronic P123 micelles. The diameter of quercetin-loaded KP407 micelles in these previous studies was 28.79 ± 0.8 nm, which is comparable to the results reported here.…”