Binary Blend of Glyceryl Monooleate and Glyceryl Monostearate for Magnetically Induced Thermo-Responsive Local Drug Delivery System

Mengesha, Abebe; Wydra, Robert J.; Hilt, J. Zach; Bummer, Paul M.

doi:10.1007/s11095-013-1230-1

Cited by 23 publications

(18 citation statements)

References 43 publications

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“…28,29 A wide variety of drug release systems have been developed, including a tunable, pH dependent matrix 30 and a magnetic field controlled system in which ferromagnetic nanoparticles are incorporated into the matrix. 31 …”

Section: Introductionmentioning

confidence: 99%

Structural insights into the cubic–hexagonal phase transition kinetics of monoolein modulated by sucrose solutions

Reese

Strango

Dell

et al. 2015

Phys. Chem. Chem. Phys.

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Using DSC (differential scanning calorimetry), we measure the kinetics of the cubic-HII phase transition of monoolein in bulk sucrose solutions. We find that the transition temperature is dramatically lowered, with each 1 mol/kg of sucrose concentration dropping the transition by 20 °C. The kinetics of this transition also slow greatly with increasing sucrose concentration. For low sucrose concentrations, the kinetics are asymmetric, with the cooling (HII-cubic) transition taking twice as long as the heating (cubic-HII) transition. This asymmetry in transition times is reduced for higher sucrose concentrations. The cooling transition (cubic-HII) exhibits Avrami exponents in the range of 2 to 2.5 and the heating transition shows Avrami exponents ranging from 1 to 3. A classical Avrami interpretation would be that these processes occur via a one or two dimensional pathway with variable nucleation rates. A non-classical perspective would suggest that these exponents reflect the time dependence of pore formation (cooling) and destruction (heating). New density measurements of monoolein show that the currently accepted value is about 5% too low; this has substantial implications for electron density modeling. Structural calculations indicate that the head group area and lipid length in the cubic-HII transition shrink by about 12 % and 4 % respectively; this reduction is practically the same as that seen in a lipid with a very different molecular structure (rac-di-12:0 β-GlcDAG) that makes the same transition. Thermodynamic considerations suggest there is a hydration shell about one water molecule thick in front of the lipid head groups in both the cubic and HII phases.

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Section: Introductionmentioning

confidence: 99%

Structural insights into the cubic–hexagonal phase transition kinetics of monoolein modulated by sucrose solutions

Reese

Strango

Dell

et al. 2015

Phys. Chem. Chem. Phys.

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“…As a lipid matrix, GMS exhibits polymorphism with three crystal forms, including α, β′ and β forms. The melting temperature of these forms follows the trend of β > β′ > α [22]. Characteristic peak of GMS at 73.73 °C is observed, which corresponds to the β configuration.…”

Section: Thermal Properties and Crystalline Structure Of Res-peg-slnsmentioning

confidence: 82%

Modification and stabilizing effects of PEG on resveratrol-loaded solid lipid nanoparticles

Wen

et al. 2016

J IRAN CHEM SOC

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“…A novel monoglyceride-based thermoresponsive drug delivery system was developed by Mengesha et al [55]. Specifically, nanocomposite lipid matrices containing mixtures of glyceryl monooleate (GMO) and glyceryl monostearate (GMS) with oleic-acid coated iron oxide MNPs were prepared (Figure 1c).…”

Section: Remote Controlled Drug Therapymentioning

confidence: 99%

“…In (c), a schematic illustration of the proposed concept of monoglyceride-based thermoresponsive drug delivery system [55]. In (d), AMF triggered in vitro release of nifedipine from GMO-GMS (75:25 wt%) matrix.…”

Section: Figurementioning

confidence: 99%

Magnetic nanoparticles and nanocomposites for remote controlled therapies

Hauser

Wydra

Stocke

et al. 2015

Journal of Controlled Release

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107

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This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of MNPs by static or alternating magnetic fields and magnetic field guidance of MNPs for drug delivery applications are summarized. Recent advances in controlled energy release for thermal therapy and nanoscale energy therapy are addressed as well. Additionally, studies that utilize MNP-based thermal therapy in combination with other treatments such as chemotherapy or radiation to enhance the efficacy of the conventional treatment are discussed.

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Binary Blend of Glyceryl Monooleate and Glyceryl Monostearate for Magnetically Induced Thermo-Responsive Local Drug Delivery System

Abstract: The in vitro NF release profiles form the monoglycerides matrix containing 0.5% OA-Fe3O4 nanoparticles after AMF activation confirmed the thermo-responsive nature of the matrix that could provide pulsatile drug release 'on-demand'.

Cited by 23 publications

References 43 publications

Structural insights into the cubic–hexagonal phase transition kinetics of monoolein modulated by sucrose solutions

Structural insights into the cubic–hexagonal phase transition kinetics of monoolein modulated by sucrose solutions

Modification and stabilizing effects of PEG on resveratrol-loaded solid lipid nanoparticles

Magnetic nanoparticles and nanocomposites for remote controlled therapies

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