Bimodal liquid biopsy for cancer immunotherapy based on peptide engineering and nanoscale analysis

Bu, Jong‐Uk; Jeong, Woojin; Jafari, Roya; Kubiatowicz, Luke J.; Nair, Ashita; Poellmann, Michael J.; Hong, Rachel; Liu, Elizabeth W.; Owen, Randall H.; Rawding, Piper A.; Hopkins, Caroline M.; Kim, DaWon; George, Daniel J.; Armstrong, Andrew J.; Wang, Andrew Z.; Bruce, Justine Y.; Zhang, Tian; Kimple, Randall J.; Hong, Seungpyo

doi:10.1016/j.bios.2022.114445

Cited by 19 publications

(11 citation statements)

References 58 publications

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“…This study examined the effects of the polyethylene glycol spacer, secondary peptide structure and peptide sequence modification on the capture efficiency. 83 The optimized pPD-1 configuration was 1.5 and 1.2 times more efficient than their total antibody counterpart (aPD-L1) in capturing tumor cells and exocrine expressing PD-L1, respectively. It showed that the common analysis of two biomarkers can further improve the accuracy of the clinical application of the system.…”

Section: Biological Properties For Isolationmentioning

confidence: 92%

Recent progress of nanostructure-based enrichment of circulating tumor cells and downstream analysis

Liu

Cheng

et al. 2023

Lab Chip

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Section: Biological Properties For Isolationmentioning

confidence: 92%

Recent progress of nanostructure-based enrichment of circulating tumor cells and downstream analysis

Liu

Cheng

et al. 2023

Lab Chip

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“…9 Second, the peptides derived from the recognition domain of antibodies are able to exhibit comparably or even higher binding affinity compared to the whole antibody. 10 Third, the properties of the peptides can be easily adjusted by chemical modification of the side groups with some other non-peptide materials or groups. [11][12][13] Fourth, the peptides can self-assemble to construct ordered supramolecular nanostructures through non-covalent intramolecular interactions, 14 for example, peptide nanotubes with strong electrical conductivity and large internal surface area, peptide nanofibers with high hardness and tensile strength, peptide nanovesicles with excellent targeting and penetration ability, and peptide nanocages with drug scaffold function.…”

Section: Introductionmentioning

confidence: 99%

Application of functional peptides in the electrochemical and optical biosensing of cancer biomarkers

et al. 2023

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“… 16–18 However, the platelets can adhere to CTCs, thereby reducing their destruction by blood flow and altering the immunogenicity. 16 , 18 The immune cells cannot recognize CTCs, which leads to an increase in their survival rate. 17 , 19 , 20 Furthermore, the platelets stimulate the shedding and metastasis of cancer cells by releasing a large number of cytokines and interact with the tumor microenvironment by enhancing inflammatory response and forming new blood vessels.…”

Section: Introductionmentioning

confidence: 99%

High Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells

Zhan¹,

Huang²,

Huang³

et al. 2023

JHC

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Purpose Recent studies indicated the vital role of platelet in enhancing the survival of circulating tumor cells (CTCs) in the blood, thereby stimulating the metastasis of tumors. CTCs have been considered an indicator of early tumor recurrence. Therefore, this study evaluated the prognostic potential of platelet count in predicting the early recurrence of hepatocellular carcinoma (HCC) in the presence of CTCs. Patients and Methods 127 patients, whose preoperative CTCs were detected, were enrolled in this study. Univariate analysis was performed to identify the significant association of factors with the early recurrence of HCC, followed by multivariate analysis to determine the independent prognostic indicators. The prediction potential was evaluated using receiver operating characteristic (ROC) curves. Results A total of 81 (63.7%) patients showed early HCC recurrence. The platelet count ≥225×10 9 /L (hazard ratio, HR: 1.679, P = 0.041), CTCs >5/5 mL (HR: 2.467, P = 0.001), and presence of microvascular invasion (MVI) (HR: 2.580, P = 0.002) were independent factors correlated with the early recurrence of HCC in multivariate analysis. The prognostic potential of the combined CTCs-platelet count (0.738) was better than that of CTCs (0.703) and platelet (0.604) alone. The subgroup analysis, excluding 23 patients with pathological cirrhosis and splenomegaly, showed that the platelet count ≥225×10 9 /L and CTCs >5/5 mL were also independent factors of early HCC recurrence. The prediction potential of the combined CTCs-platelet count was 0.753, which was better than that of the whole cohort. Kaplan–Meier survival curve analysis indicated that the HCC patients with high platelet or CTCs had the worse recurrence-free survival (RFS). Conclusion The high platelet count was an independent factor of early HCC recurrence in the presence of CTCs. The combination of preoperative CTCs and platelet count could effectively predict the early recurrence of HCC. The subgroup analysis also showed similar results.

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Bimodal liquid biopsy for cancer immunotherapy based on peptide engineering and nanoscale analysis

Cited by 19 publications

References 58 publications

Recent progress of nanostructure-based enrichment of circulating tumor cells and downstream analysis

Recent progress of nanostructure-based enrichment of circulating tumor cells and downstream analysis

Application of functional peptides in the electrochemical and optical biosensing of cancer biomarkers

High Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells

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