Application of functional peptides in the electrochemical and optical biosensing of cancer biomarkers

Cao, Yue; Zhou, Liang; Fang, Zhikai; Zou, Zihan; Zhao, Jing; Zuo, Xiaolei; Li, Genxi

doi:10.1039/d2cc06824a

Cited by 13 publications

(5 citation statements)

References 117 publications

(140 reference statements)

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“…124 Peptides are short-chain sequences of amino acids, which are typically less than fifty amino acid sequences in length and can be used for the biorecognition of infectious agents, proteins, small molecules, and disease biomarkers in biosensors. [125][126][127][128][129] They are selected for binding specific targets by screening large random peptide libraries generated using in vitro display techniques, including phage display, mRNA display, ribosome display, bacteria display, and yeast display. This step is followed by characterization, where the kinetics and thermodynamics of the peptide-target are assessed and the peptide is synthesized using solution-based or solidphase synthesis.…”

Section: Biorecognition Elements and Sensor Functionalizationmentioning

confidence: 99%

Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

Akhlaghi,

Kaur,

Adhikari

et al. 2024

ECS Sens. Plus

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There is a plethora of electrochemical biosensors developed for ultrasensitive detection of clinically-relevant biomarkers. However, many of these systems lose their performance in heterogeneous clinical samples and are too complex to be operated by end users at the point-of-care (POC), prohibiting their commercial success. Integration of biosensors with sample processing technology addresses both of these challenges; however, it adds to the manufacturing complexity and the overall cost of these systems. Herein, we review the different components of a biosensor and avenues for creating fully-integrated systems. In the context of integration, we focus on discussing the trade-offs between sensing performance, cost, and scalable manufacturing to guide the readers toward designing new electrochemical biosensors with commercialization potential.

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Section: Biorecognition Elements and Sensor Functionalizationmentioning

confidence: 99%

Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

Akhlaghi,

Kaur,

Adhikari

et al. 2024

ECS Sens. Plus

View full text Add to dashboard Cite

show abstract

“…They can be used as natural substrates in protease-based cancer diagnostic tests. Because of these benefits, peptides are appealing as useful materials in biosensing, where they have been used successfully to find indicators of cancer . Standard ways to check for and diagnose cancer include mammography for malignancy in the breast, For brain cancer, magnetic resonance imaging (MRI) is used, lower-dose computerized tomography (CT) is used for pulmonary malignancy, and endoscopy and colonoscopy are used for colon cancer. , Still, these methods have trouble telling the difference between normal and cancerous tumors when they are very small.…”

Section: Biomedical Applicationmentioning

confidence: 99%

Self-Assembly of Peptides as an Alluring Approach toward Cancer Treatment and Imaging

Ghafoor,

Song,

Zhou

et al. 2024

ACS Biomater. Sci. Eng.

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Cancer is a severe threat to humans, as it is the second leading cause of death after cardiovascular diseases and still poses the biggest challenge in the world of medicine. Due to its higher mortality rates and resistance, it requires a more focused and productive approach to provide the solution for it. Many therapies promising to deliver favorable results, such as chemotherapy and radiotherapy, have come up with more negatives than positives. Therefore, a new class of medicinal solutions and a more targeted approach is of the essence. This review highlights the alluring properties, configurations, and self-assembly of peptide molecules which benefit the traditional approach toward cancer therapy while sparing the healthy cells in the process. As targeted drug delivery systems, self-assembled peptides offer a wide spectrum of conjugation, biocompatibility, degradability-controlled responsiveness, and biomedical applications, including cancer treatment and cancer imaging.

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“…Self-assembly involves spontaneously organizing beads into well-defined patterns or structures through non-covalent interactions. By controlling the beads' size, shape, and composition, self-assembly techniques enable the fabrication of highly ordered arrays or hierarchical structures, which can enhance the sensitivity and reproducibility of the biosensors [88]. Magnetic beads made of iron oxide NP-embedded polymer matrices can self-assemble at specific locations on functionalized surfaces [89].…”

Section: Magnetic Beadsmentioning

confidence: 99%

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Cheng,

Yang,

Wang

et al. 2024

Sensors

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Demand is strong for sensitive, reliable, and cost-effective diagnostic tools for cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising diagnostic platforms based on wide-ranging cancer biomarkers owing to the versatility, high sensitivity, and flexibility to perform the multiplexing of beads. This comprehensive review highlights recent trends and innovations in the development of bead-based biosensors for cancer-biomarker detection. We introduce various types of bead-based biosensors such as optical, electrochemical, and magnetic biosensors, along with their respective advantages and limitations. Moreover, the review summarizes the latest advancements, including fabrication techniques, signal-amplification strategies, and integration with microfluidics and nanotechnology. Additionally, the challenges and future perspectives in the field of bead-based biosensors for cancer-biomarker detection are discussed. Understanding these innovations in bead-based biosensors can greatly contribute to improvements in cancer diagnostics, thereby facilitating early detection and personalized treatments.

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Application of functional peptides in the electrochemical and optical biosensing of cancer biomarkers

Abstract: Early screening and diagnosis are the most effective way to prevent the occurrence and progression of cancers, thus many biosensing strategies have been developed to achieve economic, rapid, and effective...

Cited by 13 publications

References 117 publications

Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

Self-Assembly of Peptides as an Alluring Approach toward Cancer Treatment and Imaging

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

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