Bimetallic nanozyme mediated urine glucose monitoring through discriminant analysis of colorimetric signal

Prasad, Sanjana Naveen; Anderson, Samuel R.; Joglekar, Mugdha V.; Hardikar, Anandwardhan A.; Bansal, Vipul; Ramanathan, Rajesh

doi:10.1016/j.bios.2022.114386

Cited by 43 publications

(27 citation statements)

References 76 publications

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“…They can be synthesized through various methods, including thermal decomposition (Toshima and Yonezawa, 1998), microwave (Toshima and Yonezawa, 1998), seeded growth (Chen et al, 2013), co-reduction (Toshima and Yonezawa, 1998), and galvanic displacement (Bansal et al, 2008;Xia et al, 2013;Anderson et al, 2019;Bhanushali et al, 2020) nanozyme was fabricated for colorimetric glucose detection in urine using the galvanic displacement method, where Cu was used as a sacrificial template to enhance the ambient stability of the nanozyme (Naveen Prasad et al, 2022).…”

Section: Bimetallic Nanoparticle-based Nanozymesmentioning

confidence: 99%

Advances in Nanozymes as a Paradigm for Viral Diagnostics and Therapy

et al. 2023

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Over the last few decades, humankind has constantly encountered new viral species that create havoc in the socio-economic balance worldwide. Among the method to combat these novel viral infections, fast and Point-of-care diagnosis is of prime importance to contain the spreading of viral infections. However, most sensitive diagnostic systems for viral infections are time-consuming and require well-trained professionals, making it difficult for the patients. In recent years nanozymes emerged as promising therapeutic and fast diagnostic tools due to their multienzymelike catalytic performance. Nanozymes can be designed using inorganic or organic components with tailorable physicochemical surface properties, enabling the attachment of various molecules and species on the surface of the nanozyme for specific recognition. In addition to the composition, the multienzyme-like catalytic performance can be modulated by the shape and size of the nanoparticles. Due to their multicatalytic abilities, nanozymes can be used for fast diagnosis and therapy for viral infections. Here we attempt to focus on the insights and recent explorations on the advances in designing various types of nanozymes as a theranostic tool for viral infections.

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Section: Bimetallic Nanoparticle-based Nanozymesmentioning

confidence: 99%

Advances in Nanozymes as a Paradigm for Viral Diagnostics and Therapy

et al. 2023

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“…Alternatively, noninvasive urine tests can be conducted . However, such indirect assessment suffers from poor reliability and reproducibility . Various wearable sensors have been developed to detect ions in sweat. , However, their concentration and dynamics differ from that in blood, and it is not convenient to induce sweating to enable detection.…”

Section: Introductionmentioning

confidence: 99%

Microneedle-Coupled Epidermal Sensors for In-Situ-Multiplexed Ion Detection in Interstitial Fluids

Zhu

Tan

Zheng

et al. 2023

ACS Appl. Mater. Interfaces

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Maintaining the concentrations of various ions in body fluids is critical to all living organisms. In this contribution, we designed a flexible microneedle patch coupled electrode array (MNP-EA) for the in situ multiplexed detection of ion species (Na+, K+, Ca2+, and H+) in tissue interstitial fluid (ISF). The microneedles (MNs) are mechanically robust for skin or cuticle penetration (0.21 N/needle) and highly swellable to quickly extract sufficient ISF onto the ion-selective electrochemical electrodes (∼6.87 μL/needle in 5 min). The potentiometric sensor can simultaneously detect these ion species with nearly Nernstian response in the ranges wider enough for diagnosis purposes (Na+: 0.75–200 mM, K+: 1–128 mM, Ca2+: 0.25–4.25 mM, pH: 5.5–8.5). The in vivo experiments on mice, humans, and plants demonstrate the feasibility of MNP-EA for timely and convenient diagnosis of ion imbalances with minimal invasiveness. This transdermal sensing platform shall be instrumental to home-based diagnosis and health monitoring of chronic diseases and is also promising for smart agriculture and the study of plant biology.

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“…(2) The PdRu bimetallic nanomaterials have shown superior catalytic effects. Due to synergistic and additive effects, their catalytic properties are significantly improved compared to original nanomaterials . (3) Since the synthesized bimetallic particles are comparatively small in size, they have better stability and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…Due to synergistic and additive effects, their catalytic properties are significantly improved compared to original nanomaterials. 18 (3) Since the synthesized bimetallic particles are comparatively small in size, they have better stability and biocompatibility. Therefore, the bimetallic nanozyme is anticipated with not only strong binding with the mAbs but also preferable peroxidase-like activity, which can be regarded as an efficient probe in reliable, sensitive, and selective ELISA.…”

Section: ■ Introductionmentioning

confidence: 99%

A Versatile PdRu Bimetallic Nanoenzyme-Integrated Enzyme-Linked Immunosorbent Assay for Highly Sensitive Escherichia coli O157:H7 Detection

Wang,

Bu,

Cao

et al. 2023

Anal. Chem.

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Nanozymes have drawn much attention as an enzyme mimetic with low cost and stability in enhancing analytical performance. Herein, a peroxidase-mimicking nanozyme-improved enzyme-linked immunosorbent assay (ELISA) was developed employing the bimetallic PdRu nanozyme to replace the natural enzymes as a catalytic carrier for the sensing of Escherichia coli O157:H7 (E. coli O157:H7). The PdRu nanozyme displayed ultrahigh catalytic activity, possessing a catalytic rate that was 5-fold higher than horseradish peroxidase (HRP). In addition, PdRu exhibited great biological affinity with antibody (affinity constant was about 6.75 × 1012 M) and high stability. All those advantages ensure the successful establishment and the construction of a novel colorimetric biosensor for E. coli O157:H7 detection. PdRu-based ELISA not only achieved an ultrasensitive detection sensitivity (8.7 × 102 CFU/mL) by approximately 288-fold as compared to the traditional HRP-based ELISA and also possessed satisfactory specificity and reproducibility (relative standard deviation (RSD) < 10%). Furthermore, the feasibility of PdRu-ELISA was further evaluated by detecting E. coli O157:H7 in actual samples with satisfactory recoveries, indicating its potential for applications in bioassays and clinical diagnostics.

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Bimetallic nanozyme mediated urine glucose monitoring through discriminant analysis of colorimetric signal

Cited by 43 publications

References 76 publications

Advances in Nanozymes as a Paradigm for Viral Diagnostics and Therapy

Advances in Nanozymes as a Paradigm for Viral Diagnostics and Therapy

Microneedle-Coupled Epidermal Sensors for In-Situ-Multiplexed Ion Detection in Interstitial Fluids

A Versatile PdRu Bimetallic Nanoenzyme-Integrated Enzyme-Linked Immunosorbent Assay for Highly Sensitive Escherichia coli O157:H7 Detection

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