Bimetallic DppfM(II) (M = Pt and Pd) dithiocarbamate complexes: Synthesis, characterization, and anticancer activity

Abstract

A series of bimetallic dppfM(II) (dppf = 1,1’-bis (diphenyphosphino) ferrocene; M = Pt and Pd) dithiocarbamate complexes is synthesized and characterized by spectroscopic methods and single-crystal X-ray diffraction. Their antitumor activities in vitro are investigated by MTT assays against four cancer cell lines. The anticancer studies indicate most of the complexes display good to excellent antitumor activity. Remarkably, the platinum complex with a pyrrolidinyl substituent (3b) was identified as the most promising candidate due to its high potency and broad spectrum of activity.

Stereoelectronic Mapping of Dithiocarbamates and Xanthates

“…Other factors, such as the solubility of the drugs in biological or culture media, should be taken into consideration for more detailed studies as well. Importantly, this finding mainly pertains to gold­(III) complexes, as this particular trend was not observed in the studies of other dithiocarbamato complexes. − This is unsurprising as the mechanism of action in cells would obviously differ with the change in oxidation state, geometry, and electronics of the metal complex involved.…”

“…9 With this in mind, much research was put into thiol-containing metal-dithiocarbamato complexes, which showed anticancer activity with a reduced tendency to cause renal toxicity. 8,10 Other than gold compounds, 11−17 dithiocarbamato complexes with antimony-(III), 18 platinum(II), 19,20 palladium(II), 19,20 vanadium(IV), 21 and ruthenium(II) 22 have been investigated for their cytotoxic activities as well.…”

“…One of the major drawbacks of the latter is nephrotoxicity, which is hypothesized to be due to platinum binding and inactivation of thiol-containing renal enzymes . With this in mind, much research was put into thiol-containing metal-dithiocarbamato complexes, which showed anticancer activity with a reduced tendency to cause renal toxicity. , Other than gold compounds, − dithiocarbamato complexes with antimony­(III), platinum­(II), , palladium­(II), , vanadium­(IV), and ruthenium­(II) have been investigated for their cytotoxic activities as well.…”

1,2,3-triazole-dithiocarbamate-naphthalimides: Synthesis, characterization, and biological evaluation

“…6,7 Our group recently reported tethering the biologically active group DTC to ruthenium(II) and dppfM(II) (M = Pt and Pd) units. 8,9 These novel organometallic complexescontaining DTC exhibited good anticancer activity.…”

Synthesis and characterization of a new bis-NHC palladium complex and its catalytic activity in the Mizoroki–Heck reaction

“…In recent years, the catalytic cross-coupling reactions of N-heterocyclic carbene (NHC) metal complexes have become a popular research topic. 1,2 Compared with traditional phosphine and nitrogen ligands, 3,4 NHC ligands have the following advantages: they are electron rich and strong electron donors, they strongly coordinate to metals, they are relatively stable in synthesized metal complexes [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and easy to modify, and so on. 21,22 They are typically represented by an NHC-Pd complex which exhibits excellent reactivity in catalytic reactions, mainly due to the strong σ electron-donating properties of the NHC, which makes the central Pd atom more susceptible to oxidative addition at the inactive bond.…”