Bilobalide assuages morphine‐induced addiction in hippocampal neuron cells through upregulation of microRNA‐101

Zhang, Yan; Zhai, Hongyin

doi:10.1002/jbt.22493

Cited by 3 publications

(8 citation statements)

References 41 publications

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“…BB (Fig. 7), which is a sesquiterpene trilactone extracted from the Ginkgo biloba leaf, has been indicated to exhibit multiple pharmacological effects (41)(42)(43), and it has been investigated as a therapeutic agent for cardiovascular diseases (44), neurological disorders (41,45), ethanol-induced gastric ulcer (46) and cuprizone-induced demyelination (47). Previous studies also demonstrated that BB exerts anti-inflammatory effects (27,28).…”

Section: Discussionmentioning

confidence: 99%

Bilobalide attenuates lipopolysaccharide‑induced HepG2 cell injury by inhibiting TLR4‑NF‑κB signaling via the PI3K/Akt pathway

Mao,

Yao,

Zhang

et al. 2023

Exp Ther Med

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Inflammation is involved in the pathological process underlying a number of liver diseases. Bilobalide (BB) is a natural compound from Ginkgo biloba leaves that was recently demonstrated to exert hepatoprotective effects by inhibiting oxidative stress in the liver cancer cell line HepG2. The anti-inflammatory activity of BB has been reported in recent studies. The major objective of the present study was to investigate whether BB could attenuate inflammation-associated cell damage. HepG2 cells were cultured with lipopolysaccharide (LPS) and BB, and cell damage was evaluated by measuring cell viability using MTT assay. The activity of the NF-κB signaling pathway was assessed by measuring the levels of IκBα, NF-κB p65, phosphorylated (p)-IκBα, p-p65, p65 DNA-binding activity and inflammatory cytokines IL-1β, IL-6 and TNF-α. A toll-like receptor (TLR)4 inhibitor (CLI-095) was used to detect the involvement of TLR4 in cell injury caused by LPS. In addition, the PI3K/Akt inhibitor LY294002 was applied to explore the involvement of the PI3K/Akt axis in mediating the effects of BB. The results demonstrated that LPS induced HepG2 cell injury. LPS also elevated the levels of p-IκBα, p-p65, p65 DNA-binding activity and inflammatory cytokines. However, CLI-095 significantly attenuated the LPS-induced cell damage and inhibited the activation of NF-κB signaling. BB also dose-dependently attenuated the LPS-induced cell damage, activation of NF-κB signaling and TLR4 overexpression. Furthermore, it was observed that LY294002 diminished the cytoprotective effects of BB on cell injury, TLR4 expression and NF-κB activation. These findings indicated that BB could attenuate LPS-induced inflammatory injury to HepG2 cells by regulating TLR4-NF-κB signaling.

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Section: Discussionmentioning

confidence: 99%

Bilobalide attenuates lipopolysaccharide‑induced HepG2 cell injury by inhibiting TLR4‑NF‑κB signaling via the PI3K/Akt pathway

Mao,

Yao,

Zhang

et al. 2023

Exp Ther Med

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“…The skeleton of 202 was almos same as compound 201, except for one more carbon in a CH3CH2C = O group. These compounds (199)(200)(201)(202) did not exhibit any anti-fungal activities against Gaeumannom graminis, Fusarium moniliforme, Verticillium cinnabarium, and Phyricularia oryzae, nor anti-bacterial activity against Pseudomonas solanacearum, S. aureus, and Salmonella ty murium at 100 μg/disk. Neither of them (199)(200)(201)(202) showed any nematicidal activ against Panagrellus redivivus and Caenorhabditis elegans [153].…”

Section: H Oh O Ohmentioning

confidence: 91%

“…For example, as an antioxidant, bilobalide (140) affects cerebral ischemia injury by activating the Akt/Nrf2 pathway [199]. Furthermore, Bilobalide (140) alleviated morphine-induced addiction in hippocampal neuron cells through the up-regulation of microRNA-101 [200]. In addition, bilobalide (140) inhibited 3T3-L1 preadipocyte differentiation and intracellular lipid accumulation [176] and protects ischemia/reperfusion-induced oxidative stress and inflammatory responses via the MAPK/NF-B pathways [201].…”

Section: Pestalotiopsis Uvicolamentioning

confidence: 99%

“…Bioactivity assay of the five compounds showed that (1) pestalol B (195) and pestalol C (196) exhibited antiproliferative effects at a range of 23.4-42.5 µM against 10 human tumor cell lines, including MCF-7, BT474, A549, DU145, H1975, SK-BR-3, K562, MOLT-4, U937, and BGC823; (2) pestalol A-D (194)(195)(196)(197) showed significant effects on the influenza viruses H3N2 and H1N1 with IC 50 values of 18.9-48.0 µM [151]. Four novel polyketides, pestalpolyols A-D (199)(200)(201)(202), were also isolated from s fermentation products of Pestalotiopsis sp. cr013 [153].…”

Section: H Oh O Ohmentioning

confidence: 99%

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Pestalotiopsis Diversity: Species, Dispositions, Secondary Metabolites, and Bioactivities

Wang²,

Yang³

2022

Molecules

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Pestalotiopsis species have gained attention thanks to their structurally complex and biologically active secondary metabolites. In past decades, several new secondary metabolites were isolated and identified. Their bioactivities were tested, including anticancer, antifungal, antibacterial, and nematicidal activity. Since the previous review published in 2014, new secondary metabolites were isolated and identified from Pestalotiopsis species and unidentified strains. This review gathered published articles from 2014 to 2021 and focused on 239 new secondary metabolites and their bioactivities. To date, 384 Pestalotiopsis species have been discovered in diverse ecological habitats, with the majority of them unstudied. Some may contain secondary metabolites with unique bioactivities that might benefit pharmacology.

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“…BB exerts a neuroprotective activity through their non‐competitive inhibition. Besides, BB can be utilized to treat autoimmune encephalomyelitis (Miao et al, 2020), demyelination (Sui et al, 2019), and alleviate hippocampal neuronal cell morphine addiction (Zhang & Zhai, 2020) and other diseases. Based on the above research, BB can not only effectively antagonize cerebral ischemia and ischemia–reperfusion injury, but is also a preferred drug for the treatment of AD and PD.…”

Section: Pharmacological Effects Of Bbmentioning

confidence: 99%

Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety

Xie

et al. 2021

Phytotherapy Research

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Bilobalide is a natural sesquiterpene trilactone from Ginkgo biloba leaves. It has good water solubility and is widely used in food and pharmaceutical fields. In the last decade, a plethora of studies on the pharmacological activities of bilobalide has been conducted and demonstrated that bilobalide possessed an extensive range of pharmacological activities such as neuroprotective, antioxidative, antiinflammatory, antiischemic, and cardiovascular protective activities. Pharmacokinetic studies indicated that bilobalide may have the characteristics of rapid absorption, good bioavailability, wide distribution, and slow elimination. This review aims to summarize the advances in pharmacological, pharmacokinetics, toxicity, and safety studies of bilobalide in the last decade with an emphasis on its neuroprotective and antiinflammatory activities, to provide researchers with the latest information and point out the limitations of relevant research at the current stage and the aspects that should be strengthened in future research.

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Bilobalide assuages morphine‐induced addiction in hippocampal neuron cells through upregulation of microRNA‐101

Cited by 3 publications

References 41 publications

Bilobalide attenuates lipopolysaccharide‑induced HepG2 cell injury by inhibiting TLR4‑NF‑κB signaling via the PI3K/Akt pathway

Bilobalide attenuates lipopolysaccharide‑induced HepG2 cell injury by inhibiting TLR4‑NF‑κB signaling via the PI3K/Akt pathway

Pestalotiopsis Diversity: Species, Dispositions, Secondary Metabolites, and Bioactivities

Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety

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