Bilirubin-Induced Neurological Dysfunction

Toorn, Ronald van; Brink, Philip; Smith, Johan; Ackermann, Christelle; Solomons, Regan

doi:10.1177/0883073816666473

Cited by 13 publications

(6 citation statements)

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“…The serum bilirubin level of the neonatal patient with hemolytic jaundice rapidly increases and patients have symptoms such as cardiac failure and anasarca, or even have hepatosplenomegaly in severe cases. If the disease is not treated effectively in time, it may result in death of the nerve cells and thus cause lesions, or even kernicterus ( 8 ). According to statistics of relevant reports, the mortality rate of the neonatal patients in the acute phase of kernicterus worldwide is as high as 50–70%, and the neonatal patients who survive have a 70–90% chance of exhibiting neurological sequelae caused by the lesions of nerve cells ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

An analysis on treatment effect of blue light phototherapy combined with Bifico in treating neonatal hemolytic jaundice

2018

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This study aimed to discuss and evaluate the clinical effect of blue light phototherapy combined with bifico in treating neonatal hemolytic jaundice. One hundred and twenty cases with neonatal hemolytic jaundice were randomly divided into treatment group and control group, 60 cases in each group. Neonatal patients in the control group were treated with traditional treatment, including administration of enzyme inducer phenobarbital and blue light phototherapy for 8 consecutive hours every day. Neonatal patients in the treatment group received bifico orally based on traditional treatment. Clinical effects of the two groups were observed after one course of treatment (7 days as one course). During the first course, serum bilirubin level in the treatment group treated with blue light phototherapy combined with bifico declined more rapidly (P<0.01) and more significantly (P<0.01) than that in the control group, and the mean time for eliminating jaundice was significantly reduced (P<0.05). The total effective rate was 91.67% in the treatment group, while that was 85.00% in the control group, which suggested that the treatment effect of the treatment group was better than that of the control group and the difference between the two groups was statistically significant (P<0.05). Compared with traditional treatment, the treatment effect of blue light phototherapy combined with bifico in treating neonatal hemolytic jaundice is significantly improved and the speed of eliminating jaundice is also higher. Thus, it is worthy to be applied in clinical practice.

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Section: Discussionmentioning

confidence: 99%

An analysis on treatment effect of blue light phototherapy combined with Bifico in treating neonatal hemolytic jaundice

2018

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“…NICU infants often present risk factors for hearing loss such as hyperbilirubinemia, ototoxic medication, and prematurity, making the use of OAEs and ABR crucial in this group (Watchko, 2016;Dedhia et al, 2018). Another study suggests that in cases of hyperbilirubinemia, ABR should always be used due to the low sensitivity of OAEs (van Toorn et al, 2016). Furthermore, in cases of cytomegalovirus (CMV), both OAEs and ABR should be used, as these newborns may have typical sensorineural hearing loss or ANSD (Natale et al, 2020).…”

Section: Screening Methods -Proposalmentioning

confidence: 99%

“…As crianças da UCIN frequentemente apresentam fatores de risco para surdez como a hiperbilirrubinémia, medicação ototóxica e a prematuridade, sendo crucial a utilização das OEA e dos PEAA neste grupo (Watchko, 2016;Dedhia et al, 2018). Num outro estudo, é sugerido ainda que nos casos de crianças com hiperbilirrubinémia sejam sempres utilizados os PEAA, pela baixa sensibilidade das OEA (van Toorn et al, 2016). Além disto, em casos de citomegalovírus (CMV), devem ser utilizadas as OEA e os PEAA, pois estes recém-nascidos podem ter uma hipoacusia neurossensorial típica ou ANSD (Natale et al, 2020).…”

Section: Método De Rastreio -Propostaunclassified

“…Deve também efetuarse a Tomografia Computorizada (TC) em casos sem possível etiologia, ou se o método de reabilitação sugerido é o implante coclear (Rance & Starr, 2015;Qiu et al, 2019;Wu et al, 2020). Estes exames podem evidenciar uma hipomielinização, lesões neurológicas causadas pela hiperbilirrubinémia, ou até uma hipoplasia do nervo auditivo (Van Toorn et al, 2016;Usami et al, 2017;Paquay et al, 2018) sendo possível concluir se a neuropatia é pré-sináptica ou pós-sináptica.…”

Section: A R T I G O D E R E V I S ã O | R E V I E W a R T I C Lunclassified

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Early diagnosis of Auditory Neuropathy in children: a systematic review

Gomes,

Barbosa,

Templado

et al. 2023

RevSALUS

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Introduction: Auditory Neuropathy Spectrum Disorder (ANSD) is characterized by normal cochlear function and abnormal neural function. Diagnosis must be performed early, so that rehabilitation is adequate and minimizes the negative consequences. Objectives: exhibit the procedures used for the early diagnosis of ANSD in children by developing a protocol, highlighting the importance of conducting studies on the incidence of ANSD and raising awareness among health professionals. Methods: systematic literature review. The electronic databases PubMed and Web of Science were used, applying the boolean operators "AND" and "NOT", with the terms, "Auditory Neuropathy", "diagnosis", "children", "hearing aids" and "cochlear implantation”. Results: 41 studies were analyzed after applying the inclusion/exclusion criteria, dating from 2015-2021. The USA is the country with the highest number of articles published. Discussion: The diagnosis of ANSD is made through otoacoustic emissions, cochlear microphonics and auditory brainstem response. This must be carried out in the first six months of life, and it is necessary to identify the possible etiology. Conclusion: the proposed objectives were achieved, namely the elaboration of the protocol. However it’s necessary to carry out studies on the incidence of ANSD in Portugal, as well as raising awareness among health professionals to this pathology.

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“…In China, some people used the neonatal behavioral neurological assessment to assess the clinical symptoms, but it was complex and less specific in predicting bilirubin encephalopathy. Bilirubin-induced neurological dysfunction score was easy to operate and have been used by many international researchers [6]. The total serum bilirubin and bilirubin to albumin ratio were the most commonly used laboratory examinations to predict bilirubin encephalopathy, but their usefulness is controversial.…”

Section: Introductionmentioning

confidence: 99%

Increased serum total bilirubin-albumin ratio was associated with bilirubin encephalopathy in neonates

et al. 2020

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We performed the present study to summarize the recent epidemiological characteristics of bilirubin encephalopathy and assess the role of total bilirubin-albumin ratio in the bilirubin encephalopathy. We retrospectively collected clinical data of 669 neonates with hyperbilirubinemia from the First Affiliated Hospital of Zhengzhou University between January 2015 and July 2018, including 153 neonates belonged to bilirubin encephalopathy and 516 ones were treated as control group. Compared with the control group, those with bilirubin encephalopathy have higher bilirubin-albumin ratio (13.8 ± 3.6 vs. 10.6 ± 2.5, P=0.000). The direct bilirubin and indirect bilirubin level were higher in the case group than that in the control group (P=0.000). On the contrary, the hemoglobin level was lower in the case group than that in the control group (P=0.004). There were no significant differences in gestational age (P=0.510), gender rate (P=0.313), maternal gestational diabetes ratio (P=0.071), natural childbirth ratio (P=0.686), and meconium delay (P=0.091). The results from univariate regression indicated the total bilirubin/albumin ratio was positively associated with bilirubin encephalopathy (odds ratio (OR) = 1.67, 95% confidence interval (CI): 1.59–3.14). The total bilirubin, direct bilirubin, and indirect bilirubin were also related to encephalopathy. After adjusting some potential cofounding factors, the total bilirubin-albumin was still associated with bilirubin encephalopathy. The higher total bilirubin-albumin ratio increased the risk of bilirubin encephalopathy by 23% (OR = 1.23, 95% CI: 1.16–2.48). Our results indicated that the bilirubin-albumin ratio is associated with bilirubin encephalopathy in neonates, and could be a potential predictor.

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Bilirubin-Induced Neurological Dysfunction

Cited by 13 publications

References 15 publications

An analysis on treatment effect of blue light phototherapy combined with Bifico in treating neonatal hemolytic jaundice

An analysis on treatment effect of blue light phototherapy combined with Bifico in treating neonatal hemolytic jaundice

Early diagnosis of Auditory Neuropathy in children: a systematic review

Increased serum total bilirubin-albumin ratio was associated with bilirubin encephalopathy in neonates

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