Biliary tract cancer incidence and trends in the United States by demographic group, 1999‐2013

Dyke, Alison L. Van; Shiels, Meredith S.; Jones, Gieira S.; Pfeiffer, Ruth M.; Petrick, Jessica L.; Beebe‐Dimmer, Jennifer L.; Koshiol, Jill

doi:10.1002/cncr.31942

Cited by 127 publications

(132 citation statements)

References 40 publications

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“…1 Between 2003 and 2009, an annual 5.9% increase in the incidence of iCCA was reported in the United States. 2 This sustained increase throughout all ages and ethnicity strata 3 has also been seen in European countries, [4][5][6] paralleled by an increase in iCCA-specific mortality. 7 Negative trends in iCCA incidence and mortality could be partially explained by improved diagnosis tools, more specific classification and increases in risk factors such as chronic hepatitis, metabolic syndrome and obesity.…”

Section: Introductionmentioning

confidence: 69%

Liver resection and transplantation for intrahepatic cholangiocarcinoma

Mazzaferro

Gorgen

Roayaie

et al. 2020

Journal of Hepatology

231

182

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The incidence of intrahepatic cholangiocarcinoma (iCCA) is increasing worldwide. Although several advances have been made in the past decades to better understand this complex malignancy and to develop new treatment strategies, the prognosis of iCCA remains dismal. Liver resection (LR) is the mainstay of treatment but only a minority of patients are amenable to surgery. In most cases, patients with iCCA will require a major hepatectomy for complete resection of the tumour. This may be contraindicated or increase the surgical burden in patients with chronic liver disease and small remnant liver volume. Lymphadenectomy with a minimal harvest of 6 lymph nodes is considered adequate, as microscopic nodal metastases have been shown in more than 40% of patients. Current 5-year overall survival following LR is in the range of 25%-40%. For locally advanced disease not amenable to upfront LR, neoadjuvant locoregional therapies may be used with the aim of converting these patients to resectability or even to transplantation in well-selected cases. Recent studies have shown that liver transplantation (LT) might be a treatment option for patients with unresectable very-early iCCA (i.e. < − 2 cm), with survival outcomes comparable to those of hepatocellular carcinoma. In patients with unresectable, advanced tumours, confined to the liver who achieve sustained response to neoadjuvant treatment, LT may be considered an option within prospective protocols. The role of adjuvant therapies in iCCA is still under debate. Herein, we review the recent advances in the surgical treatment of iCCA and examine its correlation with locoregional therapies, adjuvant and neo-adjuvant strategies.

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Section: Introductionmentioning

confidence: 69%

Liver resection and transplantation for intrahepatic cholangiocarcinoma

Mazzaferro

Gorgen

Roayaie

et al. 2020

Journal of Hepatology

231

182

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“…Six (four high and two moderate quality) of the eight included studies reported increasing trends, and two (both moderate quality) found decreasing trends (Figure 2, Table 1, Supplementary Table 3.4). All three studies from the USA (64)(65)(66) and one from the Netherlands (70) described increasing short-or long-term trends among persons over recent decades until at least the late 2000s. While sex-specific rates increased from 1999 to 2005 (68) in South Korea, another study from the same country reported decreasing trends among persons over the decade until 2015 (67).…”

Section: Intrahepatic Cholangiocarcinomamentioning

confidence: 99%

“…While long-term trends increased across all ages in the USA until 2013 (66), they were stable among all age groups except those aged 45-59 years, for whom they increased from 1989 to 2009 in the Netherlands (70) ( Table 2).…”

Section: Trends By Agementioning

confidence: 99%

“…Age-specific HCC incidence rates also increased from 1992 to 2015 among persons 60 years and older in all racial/ethnic groups except APIs aged 70-79 years, whereas they decreased among ages 40-59 years of all races/ethnicities since the mid-2000s (51). Long-term trends for ICC increased across all racial/ethnic groups until 2013 (66).…”

Section: Trends By Race And/or Ethnicity (Usa Only)mentioning

confidence: 99%

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Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

et al. 2020

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Background: Primary liver cancer is a leading cause of cancer deaths worldwide. Global burden varies, reflecting geographical distribution of viral hepatitis. Our objective was to perform a systematic review and meta-analysis of published current trends in incidence of adult liver cancers and histological types worldwide. Methods: This study used systematic searches of PubMed, Embase, CINAHL, and Web of Science databases for English-language peer-reviewed articles published from 1 January 2008 to 01 September 2019. Inclusion criteria were population-based studies of adult liver cancer patients with quantitative estimates of temporal trends in incidence for liver cancers and/or histological types. For multiple studies from the same geographical area, only the publication that reported the most recent trends for the same cancer type and population subgroup was included. Review was conducted per PRISMA guidelines. Two authors independently extracted data and critically assessed studies. Proposed contributors to observed trends were extracted from included articles. Study-specific estimates of the annual percentage change (APC) in incidence rates with 95% confidence intervals (CIs) were pooled using random-effects meta-analysis models. Heterogeneity was measured using the I 2 statistics and publication bias evaluated using funnel plots and Egger's tests. Results: Overall, 53 studies met the inclusion criteria, of which 31 were included in the meta-analysis. Overall, pooled APC estimates were +0.8 (95% CI −0.3, +2.0) for liver cancers combined, +2.6 (95% CI +1.2, +4.0) for hepatocellular carcinoma (HCC), and +4.3 (95% CI +2.5, +6.1) for intrahepatic cholangiocarcinoma. Subgroup analyses indicated increasing trends for liver cancers (APC +3.2, 95% CI +2.5, +3.9) and HCC (APC +3.6, 95% CI +2.9, +4.4) in the region of North America/Europe/Australia, whereas corresponding trends were decreasing (APC −1.7, 95% CI −2.2, −1.1) and stable (APC −0.7, 95% CI −1.9, +0.5) in Asia, respectively. Dasgupta et al. Liver Cancer Incidence Trends Meta-Analysis Conclusions: Incidence is increasing for adult liver cancers and HCC in Western countries, whereas trends are decreasing in the Asian region, although still remaining high. Our findings highlight the importance of viral hepatitis control and lifestyle interventions to reduce global liver cancer burden. Ongoing surveillance is also vital to detect early shifts in incidence trends.

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“…Recently, the incidence of CCA tends to show a worldwide rise, especially ICC [3][4][5][6]. In US, ICC age-adjusted incidence rate increased from 1.42 to 1.82/100,000 in males and from 0.98 to 1.45 in females between 1999 and 2013 [8]. Notably, the increasing ICC incidence is thought to be influenced by the criteria modification of CCA classification in the International Classification of Diseases for Oncology (ICD-O) coding system [3,9].…”

Section: Introductionmentioning

confidence: 99%

The Advancement of Long Non-Coding RNAs in Cholangiocarcinoma Development

Jiang¹,

Ling²

2019

J. Cancer

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Cholangiocarcinoma (CCA) is a malignancy with increasing incidence in recent years. CCA patients are usually diagnosed at advanced stage due to lack of apparent symptoms and specifically diagnostic markers. Nowadays, surgical removal is the only effective method for CCA whereas overall 5-year-survival rate keeps around 10%. Long-noncoding RNA (lncRNA), a subtype of noncoding RNA, is widely studied to be abnormally expressed in multiple cancers including CCA. LncRNA can promote proliferation, migration, invasion and inhibit apoptosis of CCA. Moreover, lncRNA is negatively correlated with the prognosis of CCA. LncRNA may contribute to the development of CCA via modulating gene transcription, sponging microRNA, regulating CCA-related signaling pathways or protein expression. LncRNA is thought to be potential diagnostic markers and therapeutic targets for CCA.

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Biliary tract cancer incidence and trends in the United States by demographic group, 1999‐2013

Cited by 127 publications

References 40 publications

Liver resection and transplantation for intrahepatic cholangiocarcinoma

Liver resection and transplantation for intrahepatic cholangiocarcinoma

Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

The Advancement of Long Non-Coding RNAs in Cholangiocarcinoma Development

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