2019
DOI: 10.7150/jca.32411
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Abstract: Cholangiocarcinoma (CCA) is a malignancy with increasing incidence in recent years. CCA patients are usually diagnosed at advanced stage due to lack of apparent symptoms and specifically diagnostic markers. Nowadays, surgical removal is the only effective method for CCA whereas overall 5-year-survival rate keeps around 10%. Long-noncoding RNA (lncRNA), a subtype of noncoding RNA, is widely studied to be abnormally expressed in multiple cancers including CCA. LncRNA can promote proliferation, migration, invasio… Show more

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Cited by 22 publications
(13 citation statements)
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“…One of the main regulatory functions of lncRNAs is to act as competing endogenous RNAs (ceRNAs) to sponge miRNAs, leading to the loss of the ability to degrade, silence, or hamper translation of their downstream genes 17 . Many lncRNAs have been shown to regulate key factors involved in cancer cells 18 and some of them represent potential diagnostic markers and therapeutic targets for CCA 19 , 20 . Therefore, we carried out the present study to explore potential upstream lncRNAs that can regulate the miR-320a/NRP-1 axis in CCA.…”
Section: Introductionmentioning
confidence: 99%
“…One of the main regulatory functions of lncRNAs is to act as competing endogenous RNAs (ceRNAs) to sponge miRNAs, leading to the loss of the ability to degrade, silence, or hamper translation of their downstream genes 17 . Many lncRNAs have been shown to regulate key factors involved in cancer cells 18 and some of them represent potential diagnostic markers and therapeutic targets for CCA 19 , 20 . Therefore, we carried out the present study to explore potential upstream lncRNAs that can regulate the miR-320a/NRP-1 axis in CCA.…”
Section: Introductionmentioning
confidence: 99%
“…As in HCC and ICC, non-coding alterations are common in cHCC-ICC, for example large cohorts have shown 22.9% of cases with TERT promoter mutations and 29.7% of cases with NEAT1 (an intergenic non-coding RNA gene for a long noncoding RNA) alterations, but detailed comparisons to HCC and ICC and how to target these changes therapeutically are not yet clear (19,(48)(49)(50).…”
Section: Genetic Characterization and Molecular Biologymentioning
confidence: 99%
“…This review introduces selected studies of lncRNAs in CCA especially from recent studies. For other lncRNAs in CCA, see previous schematic reviews (43,44).…”
Section: Cholangiocarcinoma Lncrnas As Competing Endogenous Rnas In Ccamentioning
confidence: 99%